scholarly journals Folliculosebaceous Cystic Hamartoma: A Rare Entity

2021 ◽  
Author(s):  
Manjari Kishore ◽  
Avinash Kumar ◽  
Sarita Devdhar ◽  
Monisha Choudhury
Keyword(s):  
Final Diagnosis ◽  
Cystic Mass ◽  
Histological Evaluation ◽  
Cystic Cavity ◽  
Vascular Channels ◽  
Work Up ◽  
Hair Shafts ◽  
Slow Growing ◽  
Cystic Hamartoma

Folliculosebaceous Cystic Hamartoma (FSCH) is an uncommon cutaneous hamartomatous lesion. It is basically a tumour like malformations exhibiting abnormal overgrowth of biphasic elements i.e., epithelial and mesenchymal components that are normally found in the skin. Few other hamartomas of pilosebaceous origin are trichofolliculoma, trichodiscoma, fibrofolliculoma and pilar sheath acanthoma. Though distinct, this entity shares similar histological features to Sebaceous Trichofolliculoma (STF). Hence, a proper histological examination is must in differentiating it from STF and other clinical and histological entities. Authors hereby, describes a case of FSCH in a 37-year-old male who presented with a slow growing cystic mass on his left earlobe, an uncommon location for such lesion. The mass was excised, and a detailed histological evaluation showed a characteristic multinodular growth pattern with lobules of pilosebaceous glands forming nodules around cystically dilated follicular infundibular structures. No hair shafts were seen in the cystic cavity ruling out differential diagnosis of sebaceous hyperplasia which could have been a close mimic. The intervening stroma revealed dense collagen, sheets and lobules of adipocytes, many vascular channels filled with fibrinous deposits. Perivascular adipocytes were also noted along with few nerve tissues (perineurium). A detailed clinicopathological work-up helped in arriving at a final diagnosis of FSCH with neural component. The patient was doing well till last six months of follow-up. No recurrence of similar lesion was noted in the patient.

scholarly journals Mandibular periosteal (juxtacortical) chondrosarcoma

2009 ◽  
Vol 20 (5) ◽  
pp. 428-433 ◽  
Author(s):  
Elisângela Maria Cunha Costa ◽  
Bárbara Lima Lucas ◽  
Mariana Reis Silva ◽  
Renata Hinhug Vilarinho ◽  
Paulo Rogério de Faria ◽  
...  
Keyword(s):  
Final Diagnosis ◽  
En Bloc Resection ◽  
Bloc Resection ◽  
Bone Surface ◽  
En Bloc ◽  
Grade Ii ◽  
Well Differentiated ◽  
Slow Growing ◽  
Tomography Scan

Periosteal (juxtacortical) chondrosarcoma (PC) is a well-differentiated malignant cartilage-forming tumor arising from the external bone surface, especially in long bones. The therapy of choice is en-bloc resection and, in general, its prognosis is good. This paper reports a rare case of PC affecting the mandible of a 41-year-old man. The lesion presented as a slow-growing-painless swelling that lasted 2 months. Computed tomography scan showed a tumoral mass arising from the external bone surface, extending into the adjacent soft tissue presenting patchy regions of popcorn-like calcifications. A final diagnosis of PC (grade II) was rendered after biopsy. Hemimandibulectomy was undertaken followed by complementary radiotherapy with 70 Gy. Although no episodes of recurrence or metastasis had been noticed after 18 months of follow-up, the patient died and causa mortis could not be established.

CLO19-046: Follow-Up and Diagnosis of Breast Incidentalomas on Abdominal and Chest MRI

2019 ◽  
Vol 17 (3.5) ◽  
pp. CLO19-046
Author(s):  
Samantha Rios ◽  
Kelsey Larson
Keyword(s):  
Breast Cancer ◽  
Cancer Diagnosis ◽  
Breast Mri ◽  
Breast Cancer Diagnosis ◽  
Final Diagnosis ◽  
Key Word ◽  
Improve Rate ◽  
Work Up

With the increasing use of medical imaging, it is important to report and appropriately recommend work up for incidental findings. The aim of the study was to understand how often incidental breast findings are identified on MRI chest/abdomen protocols, how these findings are followed, and the final diagnosis (benign vs malignant) of these lesions. A single institution retrospective review was performed of women who underwent abdominal or chest MRI from January 2007–January 2017 for a non–breast cancer reason with a radiologic report containing the key word “breast.” Incidental breast findings were defined as lesions not known or suspected prior to imaging. For all patients where a breast lesion was identified, the radiologic reports, follow-up imaging and procedures, and final breast pathology were reviewed. Descriptive points were analyzed using counts and percentages versus mean with standard deviation where applicable. After review, 261 patients met inclusion and exclusion criteria with demographics in Table 1. Most patients (92%) had a known or benign breast finding, but 8% (n=21) had a breast finding for which follow-up was recommended. Recommendation for follow-up included ultrasound (n=4), mammogram (n=8), per clinician (n=14), and breast MRI (n=2). Only 7/21 (33.3%) completed recommended follow-up: 86% (6/7) had normal imaging and 14% (1/7) had a new breast cancer diagnosed. Thus, the rate of new breast cancer diagnosis from abnormal abdominal or chest MRI was 4.7%. Recommendation for specific imaging follow-up (56%) (mammogram/ultrasound/MRI) in the original MRI report was 39% more likely to be completed versus “per clinician” (17%) recommendation (P=.15). Incidental breast findings on abdominal and chest MRI are uncommon, but follow-up is important to exclude new breast cancer diagnosis. Specific imaging recommendations (versus “per clinician”) appeared to improve rate of follow-up. Prior studies have looked at incidental breast findings on CT but few have assessed breast incidentalomas on abdominal MRIs, with similar rates of new breast cancer diagnosis documented in our study. Studies assessing breast incidentalomas on chest MRIs are lacking. Going forward, multi-institutional studies may further define the rate of breast cancer diagnosis after breast incidentalomas identified on abdominal/chest MRI. In addition, studies focusing on improving follow-up imaging rates are important for patient safety and quality of care.

scholarly journals Large dentigerous cyst in the maxillary sinus causing bone erosion of the sinus walls

2019 ◽  
Vol 5 (4) ◽  
pp. 1099
Author(s):  
Mohanned A. Disher ◽  
Amjed H. Ali ◽  
Imad G. Beden
Keyword(s):  
Maxillary Antrum ◽  
Bone Erosion ◽  
Dentigerous Cyst ◽  
Cystic Mass ◽  
Odontogenic Cysts ◽  
Male Predominance ◽  
Unerupted Tooth ◽  
Cystic Cavity ◽  
The Right

Dentigerous cyst is a type of odontogenic cysts occurs in the ages of twenties or thirties and rarely occurs in the first decade of life with male predominance.  In this report, a case of a large dentigerous cyst in 34 years old female patient   complaining from progressive painful swelling of the right cheek for a month duration. CT scan of the paranasal sinuses showed a well-defined solitary expansile right maxillary cystic mass eroding the antero-lateral maxilla, with a crown of a tooth projecting inside the cystic cavity.  The dentigerous cyst totally enucleated through sublabial incision in combination with nasal endoscopic approach. The unerupted tooth removed from inside the right maxillary antrum. Follow-up at 2 weeks showed no abnormality at the surgical site and no any paresthesia.

scholarly journals Case of autoimmune polyglandular syndrome type 2: how we uncovered the diagnosis

2019 ◽  
Vol 12 (2) ◽  
pp. e227187
Author(s):  
Akhila Arya P V ◽  
Jayesh Kumar ◽  
Dileep Unnikrishnan ◽  
Rishi Raj
Keyword(s):  
Hormone Replacement ◽  
Final Diagnosis ◽  
Syndrome Type ◽  
Autoimmune Polyglandular Syndrome ◽  
Autoimmune Polyglandular Syndrome Type ◽  
Loss Of Appetite ◽  
Physical Findings ◽  
Work Up

A 24-year-old man with no significant medical history presented to the medical clinic with vomiting and giddiness for 2 days, loss of appetite for 1 month and progressive fatigability for the preceding 4 months. On examination, he was found to be hypotensive and was admitted to the hospital for work-up. Considering his abnormal labs and physical findings, he was worked up and was diagnosed with primary adrenal insufficiency. On further work-up for the aetiology of his Addison’s disease, he was found to have concurrent autoimmune thyroiditis and vitiligo. A final diagnosis of autoimmune polyglandular syndrome type 2 was made. The patient was started on hormone replacement therapy and reported improvement of symptoms on 3-month follow-up visit.

scholarly journals Dermatofibrosarcoma protuberans – a wolf in sheep’s clothing: a case report and review of the literature

2021 ◽  
Vol 11 (3) ◽  
pp. 246-249
Author(s):  
Mohammad Kamrul Ahsan ◽  
Md Rashedul Islam
Keyword(s):  
Subcutaneous Tissue ◽  
Skin Flap ◽  
Dermatofibrosarcoma Protuberans ◽  
Surgical Excision ◽  
Review Of The Literature ◽  
Resonance Imaging ◽  
Diagnostic Work ◽  
Work Up ◽  
Slow Growing

Dermatofibrosarcoma protuberans (DFSP) is a locally invasive and slow growing tumor of the subcutaneous tissue. It rarely metastasizes but progressive and recurs frequently after surgical excision. The trunk and proximal extremities are the most common sites of the disease. A 53-year-old woman presented to dermatology outpatient department with a 3-cm, firm, violaceous and multinodular mass located on the left upper shoulder. Diagnostic work-up including magnetic resonance imaging and histopathological findings of biopsy were consistent with DFSP. The patient underwent wide local excision with skin flap reconstruction. No recurrence has been observed during ten months of follow-up. BIRDEM Med J 2021; 11(3): 246-249

Guideline for radioimmunotherapy of rituximab relapsed or refractory CD20+ follicular B-cell nonHodgkin´s lymphoma

2004 ◽  
Vol 43 (05) ◽  
pp. 171-176 ◽  
Author(s):  
T. Behr ◽  
F. Grünwald ◽  
W. H. Knapp ◽  
L. Trümper ◽  
C. von Schilling ◽  
...  
Keyword(s):  
Quality Control ◽  
Quality Management ◽  
Medical Physics ◽  
Essential Elements ◽  
Background Information ◽  
After Care ◽  
Complete Treatment ◽  
Close Cooperation ◽  
Work Up

Summary:This guideline is a prerequisite for the quality management in the treatment of non-Hodgkin-lymphomas using radioimmunotherapy. It is based on an interdisciplinary consensus and contains background information and definitions as well as specified indications and detailed contraindications of treatment. Essential topics are the requirements for institutions performing the therapy. For instance, presence of an expert for medical physics, intense cooperation with all colleagues committed to treatment of lymphomas, and a certificate of instruction in radiochemical labelling and quality control are required. Furthermore, it is specified which patient data have to be available prior to performance of therapy and how the treatment has to be carried out technically. Here, quality control and documentation of labelling are of greatest importance. After treatment, clinical quality control is mandatory (work-up of therapy data and follow-up of patients). Essential elements of follow-up are specified in detail. The complete treatment inclusive after-care has to be realised in close cooperation with those colleagues (haematology-oncology) who propose, in general, radioimmunotherapy under consideration of the development of the disease.

Autoimmune Pancreatitis – Diagnosis, Management and Longterm Follow-up

2014 ◽  
Vol 23 (2) ◽  
pp. 179-185 ◽  
Author(s):  
Suvadip Chatterjee ◽  
Kofi W. Oppong ◽  
John S. Scott ◽  
Dave E. Jones ◽  
Richard M. Charnley ◽  
...  
Keyword(s):  
Autoimmune Pancreatitis ◽  
Rare Condition ◽  
Team Approach ◽  
Diagnostic Challenge ◽  
Multisystem Disorder ◽  
North East ◽  
The North ◽  
Work Up ◽  
Igg4 Level

Background & Aims: Autoimmune pancreatitis (AIP) is a fibroinflammatory condition affecting the pancreas and could present as a multisystem disorder. Diagnosis and management can pose a diagnostic challenge in certain groups of patients. We report our experience of managing this condition in a tertiary pancreaticobiliary centre in the North East of England.Methods: Patients were identified from a prospectively maintained database of patients diagnosed with AIP between 2005 and 2013. Diagnosis of definite/probable AIP was based on the revised HISORt criteria. When indicated, patients were treated with steroids and relapses were treated with azathioprine. All patients have been followed up to date.Results: Twenty-two patients were diagnosed with AIP during this period. All patients had pancreatic protocol CT performed while some patients had either MR or EUS as part of the work up. Fourteen out of 22 (64%) had an elevated IgG4 level (mean: 10.9 g/L; range 3.4 - 31 g/L). Four (18%) patients underwent surgery. Extrapancreatic involvement was seen in 15 (68%) patients, with biliary involvement being the commonest. Nineteen (86%) were treated with steroids and five (23%) required further immunosuppression for treatment of relapses. The mean follow up period was 36.94 months (range 7 - 94).Conclusion: Autoimmune pancreatitis is being increasingly recognized in the British population. Extrapancreatic involvement, particularly extrahepatic biliary involvement seems to be a frequent feature.Diagnosis should be based on accepted criteria as this significantly reduces the chances of overlooking malignancy. Awareness of this relatively rare condition and a multi-disciplinary team approach will help us to diagnose and treat this condition more efiectively thereby reducing unnecessary interventions.

scholarly journals Early recognition of PIMS-TS: a single centre retrospective review

2021 ◽  
Vol 5 (1) ◽  
pp. e001011
Author(s):  
Roshni Mistry ◽  
Nicola Scanlon ◽  
James Hibberd ◽  
Fionnghuala Fuller
Keyword(s):  
Early Recognition ◽  
Febrile Illness ◽  
Final Diagnosis ◽  
University Hospital ◽  
Single Centre ◽  
Retrospective Case ◽  
Reactive Protein ◽  
Review Reports ◽  
Specific Symptoms

IntroductionResearch into paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) has focused on tertiary level management. This review reports on symptoms and investigations at presentation.MethodsSingle centre retrospective case note analysis of patients fulfilling PIMS-TS diagnostic criteria from March to May 2020 in a London district level university hospital.ResultsSix patients presented in the week prior to their final diagnosis with fever and non-specific symptoms. Raised C-reactive protein (CRP), lymphopenia and hyponatraemia were noted. Kawasaki-like symptoms were under-represented in all patients.InterpretationThe results suggest that a proportion of children with early PIMS-TS present with a non-specific febrile illness and abnormal blood results. Further research is needed to determine the most appropriate identification and follow-up of these children.

scholarly journals Parenchymal mucinous cystadenoma of the kidney: a case report and literature review

2021 ◽  
Vol 27 (1) ◽  
Author(s):  
Mahmoudreza Kalantari ◽  
Shakiba Kalantari ◽  
Mahdi Mottaghi ◽  
Atena Aghaee ◽  
Salman Soltani ◽  
...  
Keyword(s):  
Renal Cyst ◽  
Left Kidney ◽  
Previous History ◽  
Mucinous Cystadenoma ◽  
Single Layer ◽  
Renal Cysts ◽  
Cystic Mass ◽  
Flank Pain ◽  
History Of

Abstract Background Mucinous cystadenoma (MC) of the kidney is exceedingly rare. We found 22 similar cases in the literature. These masses are underdiagnosed due to radiologic similarities with simple renal cysts. Case presentation A 66-year-old man with a previous history of hypertension and anxiety was referred to our tertiary clinic with left flank pain. Ultrasound revealed a 60 mm-sized, complex cystic mass with irregular septa in the lower pole of the left kidney (different from last year's sonographic findings of a simple benign cyst with delicate septa). CT scan showed the same results plus calcification. Due to suspected renal cell carcinoma, a radical nephrectomy was performed. Postoperative histopathologic examination revealed a cyst lined by a single layer of columnar mucin-producing cells with small foci of pseudo-stratification, consistent with the MC’s diagnosis. The first follow-up visit showed normal blood pressure without medication and no flank pain and anxiety after a month. Conclusion It is quite challenging to distinguish the primary MC of the kidney from a simple renal cyst based on clinical and imaging findings. The radiologic features of these entities overlap significantly. Thus, complex renal cyst and renal cysts with mural nodules should be followed closely to detect malignancy earlier.

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