scholarly journals Prevalence of blaPER-1 and Integrons in Ceftazidime-Resistant Gram-Negative Bacteria at a University Hospital in Turkey

2013 ◽  
Vol 66 (2) ◽  
pp. 146-148 ◽  
Author(s):  
Bayrı Eraç ◽  
Mine Hoşgör-Limoncu ◽  
Şafak Ermertcan ◽  
Hüseyin Taşlı ◽  
Şöhret Aydemir
Keyword(s):  
University Hospital ◽  
Gram Negative Bacteria ◽  
Gram Negative

scholarly journals 832. Assessment of Risk Factors Associated with Wide-resistance Gram-negative Bacteria Infections

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S457-S457
Author(s):  
Henry Pablo Lopes Campos e Reis ◽  
Ana Beatriz Ferreira Rodrigues ◽  
Julio César Castro Silva ◽  
Lia Pinheiro de Lima ◽  
Talita Lima Quinaher ◽  
...  
Keyword(s):  
Risk Factors ◽  
Mechanical Ventilation ◽  
Univariate Analysis ◽  
Multidrug Resistant ◽  
University Hospital ◽  
Gram Negative Bacteria ◽  
Multiresistant Pathogens ◽  
Gram Negative ◽  
Contact Isolation ◽  
Bladder Catheter

Abstract Background Enterobacteria and multidrug-resistant non-fermenting Gram-negative bacilli present a challenge in the management of invasive infections, leading to mortality rates due to their limited therapeutic arsenal. The objective of this work was to analyze risk factors that may be associated with these infections, for a better situational mapping and assertive decision-making in a university hospital in Brazil. Methods The study was conducted between January and September 2019, with 167 patients in contact isolation at a university hospital in Brazil. Potential outcome-related variables for wide-resistance Gram-negative bacteria (BGN) infections were evaluated. Risk factors were identified from univariate statistical analysis using Fisher’s test. Results 51 (30.5%) out of 167 patients in contact isolation evolved with wide-resistance BGN infection. Risk factors in univariate analysis were age, hospital unit and previous use of invasive devices. Patients aged up to 59 years were more likely to progress to infection than those aged over 60 years (p 0.0274, OR 2.2, 95% CI 1.1-4.5). Those admitted to the oncohematology (p < 0.001, OR 32.5, Cl 9.1-116.3) and intensive care unit (p < 0.001, OR 28.0, Cl 3.5-225.9) units were more likely to develop this type of infection. The least likely were those admitted to a kidney transplant unit (p 0.0034, OR 15.33, Cl 1.8-131.0). Prior use of mechanical ventilation (p 0.0058, OR 12.2, Cl 2.0-76.1) and delayed bladder catheter (p 0.0266, OR 5.0, Cl 1.2-20.1) in patients with respiratory and urinary tract infection, respectively, were also reported as risk factors related to these infections. The gender of the patients was not significant for the study. Conclusion This study determined that variables such as age, hospitalization unit, use of mechanical ventilation and delayed bladder catheter could be considered important risk factors in triggering the infectious process by wide-resistant gram-negative bacteria. Thus, the analysis of these factors becomes a great foundation to prevent the development of multiresistant pathogens through prevention strategies, prophylaxis management and more targeted empirical therapies. Disclosures All Authors: No reported disclosures

High Level of Colistin Resistant Gram-negative Bacteria in a University Hospital in Bulgaria

2021 ◽  
Author(s):  
Yulia Marteva-Proevska ◽  
Tsvetan Velinov ◽  
Rumyana Markovska ◽  
Dilana Dobrikova ◽  
Liudmila Boyanova ◽  
...  
Keyword(s):  
University Hospital ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
High Level

scholarly journals CONSUMPTION AND BACTERIAL RESISTANCE TO AMINOGLYCOSIDES AT SUDANESE UNIVERSITY HOSPITAL

2018 ◽  
Vol 11 (8) ◽  
pp. 434
Author(s):  
Einas A Bakheit ◽  
Kamal M Elhag ◽  
Abduelmula R Abduelkarem ◽  
Nada A Basheer
Keyword(s):  
Bacterial Resistance ◽  
Antimicrobial Agents ◽  
Anatomical Therapeutic Chemical ◽  
Statistical Significance ◽  
Linear Regression Analysis ◽  
University Hospital ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Defined Daily Doses ◽  
Hospital Wards

Objectives: The objective of this study was to describe patterns of antimicrobial resistance to gentamicin (Gen) and amikacin (Ak) among Gram-negative aerobic bacteria during 1-year period and to determine the association between antibiotic resistance and the consumption of Gen.Methods: Aminoglycosides consumption at Soba University Hospital wards was measured and susceptibility of Gram-negative bacteria for the same period was evaluated. Consumption data were converted to defined daily doses (DDDs)/100 bed days based on DDD/anatomical therapeutic chemical the WHO system. The association between the frequency of strains resistant to Gen and Ak and their consumption was assessed by linear regression analysis using Spearman’s correlation. The level of statistical significance was set at p<0.05.Results: A total of 973 Gram-negative isolates were identified and tested for antimicrobial susceptibility to Gen and Ak. Resistance to Gen alone was found to be 19.42%; n=189, resistance to Ak alone was found to be 3.08%; n=30, and resistance to Gen plus Ak was found to be 5.24%; n=51. Pseudomonas aeruginosa was the most resistant pathogen to Ak plus Gen (2.26%; n=22). A positive correlation between the increases in the use of Gen and the prevalence of bacterial resistance among hospital wards was found (correlation coefficient r=0.6; p=0.04).Conclusion: Gen and Ak are still highly active antimicrobial agents for the treatment of aerobic Gram-negative bacteria at times of intensified resistance to other antimicrobial agents. Monitoring the use of aminoglycosides is very important too. 

scholarly journals Microbial infection and antibiotic resistance patterns among Jordanian intensive care patients

2021 ◽  
Vol 2 (3) ◽  
pp. 515-520
Author(s):  
A. A. Shehabi ◽  
L. Baadran
Keyword(s):  
Intensive Care ◽  
University Hospital ◽  
Gram Negative Bacteria ◽  
Microbial Infection ◽  
Candida Spp ◽  
Gram Positive ◽  
Gram Negative ◽  
Adult Intensive Care Unit ◽  
Microbial Infections ◽  
Almost All

Microbial infections were observed in 30% [155/519] of all patients consecutively admitted in 1993 to the adult intensive care unit in the Jordan University Hospital in Amman. Gram-negative bacteria were involved in 110 [49%], Gram-positive bacteria in 69 [31%], mixed bacteria species in 25 [11%] and Candida spp. in 19 [9%] of all 223 infection episodes. Five species were isolated most frequently:Staphylococcus aureus [40], Acinetobacter spp. [28] Pseudomonas spp. [22], Enterobacter spp. [20] and Klebsiella spp. [17]. Resistance to most commonly available antibiotics was moderate to very high among Gram-positive and Gram-negative isolates. Almost all Gram-negative bacteria were sensitive to imipenem and ciprofloxacin

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