Relationship between Vitamin D Status, Dyslipaedemia and Antioxidant Status in Children with Idiopathic Nephrotic Syndrome in South West, Nigeria

Dysregulated lipid metabolism and oxidative stress are strong factors that are implicated in the development of proteinuria and glomerular injury in Nephrotic Syndrome (NS). Vitamin D seems to be a promising tool in influencing lipid metabolism and antioxidant status in NS. Aim: This study aims at investigating the relationship between Vitamin D, dyslipaedemia and oxidative stress in NS. Study Design: This is a case-control study. Place and Duration of Study: Children’s Outpatient Clinic (CHOP) of University College Hospital (UCH) Ibadan, Nigeria between year 2019-2021. Methods: This study involves fifty children aged 5 to 12 years, freshly diagnosed with Idiopathic NS and fifty apparently healthy children as control. Blood samples were taken from them and analytes quantified by standard laboratory methods. Students’ t test and Pearson correlation were used to compare variables between the two groups respectively. Results: Results showed significant decrease (P <.001) in Vit. D levels, GPX, SOD and CAT in NS. A significant decrease (P<.001) occurred in HDL, a significant increase (P <.001) in TG, TC and LDL levels in children with NS when compared with the control. There was a strong significant positive relationship between Catalase and Vit. D, SOD and Vit. D (r= 0.896, 0.869 respectively, P<.001) in NS. While a weak non significant positive relationship occurred between HDL and Vit. D, GPX and Vit D (r=0.0585, 0.0236 respectively, P >.001). A weak negative relationship occurred between TG and Vit. D, TC and Vit. D, LDL and Vit. D (r=-0.0432,-0.219, -0.231 respectively, P>.001), in NS. Thus, vitamin D insufficiency influences serum lipid profiles and antioxidants in paediatric Idiopathic NS.

Download Full-text

Association between calcitriol and paricalcitol with oxidative stress in patients with hemodialysis

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000641 ◽

2020 ◽

pp. 1-8

Author(s):

Hasan Haci Yeter ◽

Berfu Korucu ◽

Elif Burcu Bali ◽

Ulver Derici

Keyword(s):

Oxidative Stress ◽

Vitamin D ◽

Antioxidant Status ◽

Total Antioxidant Status ◽

Stress Index ◽

Total Oxidant Status ◽

Vitamin D Analog ◽

Total Antioxidant ◽

Oxidant Status ◽

And Oxidative Stress

Abstract. Background: The pathophysiological basis of chronic kidney disease and its complications, including cardiovascular disease, are associated with chronic inflammation and oxidative stress. We investigated the effects of active vitamin D (calcitriol) and synthetic vitamin D analog (paricalcitol) on oxidative stress in hemodialysis patients. Methods: This cross-sectional study was composed of 83 patients with a minimum hemodialysis vintage of one year. Patients with a history of any infection, malignancy, and chronic inflammatory disease were excluded. Oxidative markers (total oxidant and antioxidant status) and inflammation markers (C-reactive protein and interleukin-6) were analyzed. Results: A total of 47% (39/83) patients were using active or analog vitamin D. Total antioxidant status was significantly higher in patients with using active or analog vitamin D than those who did not use (p = 0.006). Whereas, total oxidant status and oxidative stress index were significantly higher in patients with not using vitamin D when compared with the patients who were using vitamin D preparation (p = 0.005 and p = 0.004, respectively). On the other hand, total antioxidant status, total oxidant status, and oxidative stress index were similar between patients who used active vitamin D or vitamin D analog (p = 0.6; p = 0.4 and p = 0.7, respectively). Conclusion: The use of active or selective vitamin D analog in these patients decreases total oxidant status and increases total antioxidant status. Also, paricalcitol is as effective as calcitriol in decreasing total oxidant status and increasing total antioxidant status in patients with chronic kidney disease.

Download Full-text

Vitamin D deficiency, oxidative stress and antioxidant status: only weak association seen in the absence of advanced age, obesity or pre-existing disease

British Journal Of Nutrition ◽

10.1017/s000711451700188x ◽

2017 ◽

Vol 118 (1) ◽

pp. 11-16 ◽

Cited By ~ 15

Author(s):

Erica W. Wang ◽

Parco M. Siu ◽

Marco Y. Pang ◽

Jean Woo ◽

Andrew R. Collins ◽

...

Keyword(s):

Oxidative Stress ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Antioxidant Status ◽

Total Antioxidant Status ◽

Advanced Age ◽

Vitamin D Status ◽

Oxidative Stress Biomarkers ◽

Antioxidant Power ◽

And Oxidative Stress

AbstractVitamin D deficiency (plasma 25-hydroxycholecalciferol (25(OH)D)<50 nmol/l) is highly prevalent, increases risk of non-communicable diseases (NCD) and associates with increased oxidative stress in obese subjects, the elderly and patients suffering from NCD. If confirmed as an independent driver of oxidative stress, nutritional and other public health strategies to improve vitamin D status would be strongly supported. We investigated vitamin D/oxidative stress links without the confounding effects of advanced age, obesity, smoking or pre-existing disease. Plasma 25(OH)D and biomarkers of oxidative stress and antioxidant status (plasma allantoin, oxidised LDL, ferric reducing antioxidant power (FRAP), ascorbic acid, urine 8-oxo-7,8-dihydro-2'-deoxyguanosine) were measured in fasting samples from 196 consenting, healthy adults aged 18–26 years. Correlation between 25(OH)D and each biomarker as well as biomarker differences across 25(OH)D quartiles and groups (<25/25–49/≥50 nmol/l) were investigated. Median 25(OH)D was 40 nmol/l; >70 % of participants were vitamin D deficient. No significant correlations and no biomarker differences across 25(OH)D quartiles or groups were seen except for total antioxidant status. A weak direct association (r0·252,P<0·05) was observed between 25(OH)D and FRAP, and those in the lowest 25(OH)D quartile and group had significantly lower FRAP values. Results did not reveal a clear link between vitamin D status and oxidative stress biomarkers in the absence of advanced age, obesity and disease, though some evidence of depleted antioxidant status in those with vitamin D deficiency was seen. Poor antioxidant status may pre-date increased oxidative stress. Study of effects of correction of deficiency on antioxidant status and oxidative stress in vitamin D-deficient but otherwise healthy subjects is needed.

Download Full-text

The effect of vitamin D supplementation on plasma non-oxidised PTH in a randomised clinical trial

Endocrine Connections ◽

10.1530/ec-19-0097 ◽

2019 ◽

Vol 8 (5) ◽

pp. 518-527 ◽

Cited By ~ 6

Author(s):

Stan Ursem ◽

Vito Francic ◽

Martin Keppel ◽

Verena Schwetz ◽

Christian Trummer ◽

...

Keyword(s):

Oxidative Stress ◽

Clinical Trial ◽

Vitamin D ◽

Lipid Metabolism ◽

Randomised Clinical Trial ◽

Vitamin D Supplementation ◽

Hormonal Status ◽

Hypertensive Patients ◽

And Oxidative Stress

Objective PTH can be oxidised in vivo, rendering it biologically inactive. Non-oxidised PTH (n-oxPTH) may therefore give a better image of the hormonal status of the patient. While vitamin D supplementation decreases total PTH (tPTH) concentration, the effect on n-oxPTH concentration is unexplored. We investigated the effect of vitamin D on n-oxPTH concentration in comparison to tPTH and compared the correlations between parameters of calcium, bone and lipid metabolism with n-oxPTH and tPTH. Methods N-oxPTH was measured in 108 vitamin D-insufficient (25(OH)D <75 nmol/L) hypertensive patients, treated with vitamin D (2800 IE daily) or placebo for 8 weeks in the Styrian Vitamin D Hypertension Trial (NCT02136771). We calculated the treatment effect and performed correlation analyses of n-oxPTH and tPTH with parameters of calcium, bone and lipid metabolism and oxidative stress. Results After treatment, compared to placebo, 25(OH)D concentrations increased, tPTH decreased by 9% (P < 0.001), n-oxPTH by 7% (P = 0.025) and the ratio of n-oxPTH/tPTH increased (P = 0.027). Changes in phosphate and HDL concentration correlated with changes in n-oxPTH, but not tPTH. Conclusions tPTH and n-oxPTH decrease upon vitamin D supplementation. Our study suggests that vitamin D supplementation reduces the oxidation of PTH, as we observed a small but significant increase in the non-oxidised proportion of PTH upon treatment. In addition, we found that changes in phosphate and HDL concentration showed a relationship with changes in n-oxPTH, but not tPTH. This may be explained by the biological activity of n-oxPTH. Further research should be carried out to establish the clinical relevance of n-oxPTH.

Download Full-text

Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis

Food & Function ◽

10.1039/d0fo02910f ◽

2021 ◽

Vol 12 (5) ◽

pp. 2323-2334

Author(s):

Shihong Zheng ◽

Peichang Cao ◽

Zequn Yin ◽

Xuerui Wang ◽

Yuanli Chen ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Metabolism ◽

Liver Fibrosis ◽

Liver Damage ◽

Liver Diseases ◽

Potential Drug ◽

Abnormal Lipid Metabolism ◽

And Oxidative Stress

Apigenin prevented the DDC-induced abnormal lipid metabolism, liver damage and liver fibrosis by reducing inflammation and oxidative stress. Apigenin might be a potential drug for the treatment of cholestatic liver diseases.

Download Full-text