Antihyperglycemic and Antihyperlipidemic Activity of Sida spinosa linn. Root in Streptozotocin- Induced Diabetic Rats

Objective: The present study was aimed to evaluate antihyperglycemic and antihyperlipidemic activities of methanolic extract of Aristolochia bracteolata (MEAB) against dexamethasone-induced diabetic rat model.Methods: Methanolic extract was prepared by soxhlet extraction and was evaluated for antihyperglycemic and antihyperlipidemic activity using dexamethasone-induced model. The MEAB was administered orally at a dose of 200 and 400 mg/kg body weight glibenclamide was used as standard drug. On 0th and 11th day, blood was collected by retro-orbit plexus.Results: In this model blood glucose levels were determined on 0th and 11th days and MEAB significantly reduced the blood glucose levels in diabetic rats. The effect of MEAB on serum lipid profile such as total cholesterol (TC), triglycerides (TGs), low-density lipoprotein (LDL), very LDL (VLDL), and high-density lipoprotein (HDL) was also measured on the 11th day in the diabetic rats. Significant reduction in TC, TGs, LDL, and VLDL levels and improvement in HDL level were observed in diabetic rats.Conclusion: From the results, it was found that the MEAB possess antihyperglycemic and antihyperlipidemic activities.

Download Full-text

ANTIHYPERGLYCEMIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF JATROPHA GOSSYPIFOLIA METHANOLIC EXTRACT IN STREPTOZOTOCIN-NICOTINAMIDE INDUCED DIABETIC RATS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2017.v10i11.20985 ◽

2017 ◽

Vol 10 (11) ◽

pp. 326 ◽

Cited By ~ 2

Author(s):

Issac Praveen Kumar ◽

Ishan Malhotra ◽

Sujatha Sundaresan ◽

Alwin Dev

Keyword(s):

Liver Function ◽

Glycogen Content ◽

Methanolic Extract ◽

Density Lipoprotein ◽

Experimental Period ◽

Liver Glycogen ◽

Treated Group ◽

Diabetic Rats ◽

Antihyperlipidemic Activity ◽

Jatropha Gossypifolia

Objective: The objective of the present study is to explore the antihyperglycemic and antihyperlipidemic activities of Jatropha gossypifolia methanolic extract (ME) in streptozotocin (STZ)-nicotinamide (NIC) induced diabetic model.Methods: Type II diabetes was induced by a single dose of NIC (110 mg/kg) and STZ (50 mg/kg b.w.) intraperitoneally. The diabetic animals were treated with ME (50 mg/kg and 100 mg/kg b.w.) of J. gossypifolia. At the end of experimental period, the effect of the ME on creatinine level, triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very LDL (VLDL) were analyzed. Liver function parameters such as glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT) were analyzed and liver glycogen content was estimated spectrophotometrically. After scarification of animals, the liver was collected and subjected to histopathology analysis. Glycogen content was estimated spectrophotometrically.Results: The ME treated diabetic rats showed a significant increase in HDL level and a decrease in creatinine, TG, TC, and VLDL levels. The treated group showed a significant decrease in liver function parameters such as GOT and GPT levels and significantly increased the liver glycogen content.Conclusion: These findings demonstrate that ME possess antihyperglycemic and antihyperlipidemic activity against STZ - NIC induced diabetic rats.

Download Full-text