Hyaluronan in the Skin: Mechanisms of Age-Dependent and UVA-Provoked Down-Regulated Secretion of Hyaluronan by Human Dermal Fibroblasts and Prospective Agents to Ameliorate the Hyaluronan Deficiency in Chronologically Aged Skin and Photo-aged Skin

2021 ◽  
Keyword(s):  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Regulated Secretion ◽  
Age Dependent ◽  
Aged Skin

scholarly journals Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Eun-Mi Noh ◽  
Jinny Park ◽  
Hwa-Ryung Song ◽  
Jeong-Mi Kim ◽  
Minok Lee ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Signaling Pathway ◽  
Skin Aging ◽  
Dermal Fibroblasts ◽  
Ros Generation ◽  
Human Dermal Fibroblasts ◽  
Chronological Aging ◽  
Aged Skin ◽  
Pi3k Signaling Pathway ◽  
High Level

Reactive oxygen species (ROS) play a major role in both chronological aging and photoaging. ROS induce skin aging through their damaging effect on cellular constituents. However, the origins of ROS have not been fully elucidated. We investigated that ROS generation of replicative senescent fibroblasts is generated by the modulation of phosphatidylinositol 3,4,5-triphosphate (PIP3) metabolism. Reduction of the PTEN protein, which dephosphorylates PIP3, was responsible for maintaining a high level of PIP3 in replicative cells and consequently mediated the activation of the phosphatidylinositol-3-OH kinase (PI3K)/Akt pathway. Increased ROS production was blocked by inhibition of PI3K or protein kinase C (PKC) or by NADPH oxidase activating in replicative senescent cells. These data indicate that the signal pathway to ROS generation in replicative aged skin cells can be stimulated by reduced PTEN level. Our results provide new insights into skin aging-associated modification of the PI3K/NADPH oxidase signaling pathway and its relationship with a skin aging-dependent increase of ROS in human dermal fibroblasts.

Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts

2012 ◽  
Vol 133 (7) ◽  
pp. 498-507 ◽  
Author(s):  
Pim Dekker ◽  
David Gunn ◽  
Tony McBryan ◽  
Roeland W. Dirks ◽  
Diana van Heemst ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dermal Fibroblasts ◽  
Human Dermal Fibroblasts ◽  
Age Dependent
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