Urinary Uric Acid to Urinary Creatinine Ratio- A Very Promising Biochemical Marker for Perinatal Asphyxia!!!

2021 ◽  
pp. 148-156
Author(s):  
Siddharth . ◽  
Preeti Lata Rai ◽  
P. L. Prasad
Keyword(s):  
Uric Acid ◽  
Biochemical Marker ◽  
Perinatal Asphyxia ◽  
Creatinine Ratio ◽  
Urinary Creatinine

scholarly journals Urinary uric acid or urinary creatinine ratio as a non-invasive marker for perinatal asphyxia

2020 ◽  
Vol 7 (6) ◽  
pp. 1378
Author(s):  
Siddharth . ◽  
Preeti Lata Rai ◽  
P. L. Prasad
Keyword(s):  
Uric Acid ◽  
Early Recognition ◽  
Perinatal Asphyxia ◽  
Birth Asphyxia ◽  
Neonatal Morbidity ◽  
Cerebral Injury ◽  
Creatinine Ratio ◽  
Urinary Creatinine ◽  
Spot Urine ◽  
Non Invasive

Background: Perinatal asphyxia is amongst the common problem of neonates and there exists a significant contribution to the neonatal morbidity and mortality. It is observed as a common and a vital cause of the preventable cerebral injury. The prediction of the perinatal asphyxial outcome is very important but dreadful. There is a limited role for APGAR score to predict the immediate outcome, like HIE and the long-term neurological sequelae observational error may happen in APGAR. But the biochemical parameters can truly be relied upon. This study was done to assess urinary uric acid/urinary creatinine ratio (UA/Cr) as a non-invasive marker for perinatal asphyxia and co-relate its absolute value to the degree of the perinatal asphyxia.Methods: In this prospective case control study conducted in the Pediatrics Department of Shri Ram Murti Smarak Institute of Medical Sciences between Nov 2017 to May 2019, 42 asphyxiated and 42 non-asphyxiated newborns were included. Detailed history and assessment were for all the enrolled newborns. Spot urine samples were sent for the uric acid and creatinine estimation. Results were documented, and statistical analysis was performed.Results: Urinary uric acid to creatinine ratio used as additional non-invasive, early and easy biochemical marker of the birth asphyxia that biochemically supports severity grading and clinical diagnosis of the asphyxia by APGAR score.Conclusions: The ratio of the urinary uric acid and creatinine enables rapid and early recognition of asphyxial injury and also the evaluation of its severity and potential for short-term morbidity or death.

scholarly journals Study of urinary uric acid to creatinine ratio as a biochemical marker of perinatal asphyxia and its correlation with Apgar Score

2018 ◽  
Vol 5 (4) ◽  
pp. 1485
Author(s):  
Yathiraj Sreekrishna ◽  
Adarsh Eregowda ◽  
Aarti Sharma H. L.
Keyword(s):  
Uric Acid ◽  
Clinical Diagnosis ◽  
Apgar Score ◽  
Biochemical Marker ◽  
Perinatal Asphyxia ◽  
Birth Asphyxia ◽  
Creatinine Ratio ◽  
Spot Urine ◽  
Non Invasive ◽  
Severity Grading

Background: Perinatal asphyxia is a common neonatal problem and contributes significantly to neonatal morbidity and mortality. Every hour, 104 children die as a result of asphyxia. In India; between 250,000 to 350,000 infants die each year secondary to birth asphyxia and mostly within the first three days of life. The present study was performed to determine the Urinary Uric Acid to Creatinine Ratio in perinatal asphyxia and its correlation between APGAR score and urinary uric acid to creatinine ratio in perinatal asphyxia.Methods: A randomized case control hospital-based study was conducted on 50 asphyxiated and 50 normal newborn. Urinary uric acid and creatinine were estimated in spot urine within 24 hours after birth in both cases and controls. A ratio between the concentrations of uric acid to creatinine was estimated and comparison done between cases and controls.Results: Urinary uric acid to creatinine ratio can be used as an additional non-invasive, easy and early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and the severity grading of asphyxia by APGAR score.Conclusions: Urinary uric acid to creatinine ratio can be used as an additional non-invasive, easy and early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and the severity grading of asphyxia by APGAR score.

TO STUDY THE CORRELATION OF URINARY URIC ACID AND CREATININE RATIO IN BIRTH ASPHYXIA

2021 ◽  
pp. 53-54
Author(s):  
B Revanth Reddy ◽  
Gauri Chauhan ◽  
Anand Kumar Bhardwaj ◽  
Sasanka Chakrabarti
Keyword(s):  
Uric Acid ◽  
Apgar Score ◽  
Perinatal Asphyxia ◽  
Birth Asphyxia ◽  
Control Group ◽  
P Value ◽  
Creatinine Ratio ◽  
Spot Urine ◽  
Spot Urine Sample ◽  
And Control

Introduction: Perinatal asphyxia is one of the leading causes of perinatal morbidity and mortality. Feasible and early biochemical markers to diagnose and predict the neurologic outcome is a great need of time as APGAR score alone is inuenced by various factors. The present study was performed to determine the urinary uric acid to creatinine ratio in perinatal asphyxia and its correlation with APGAR score and compare urinary uric acid to creatinine ratio with Sarnat and Sarnat staging. Materials and Methods: This study was carried out on 100 term neonates with an equal number of cases and control 50 each, control group being the neonates with Apgar score ≥ 7 at 1 minute of life and cases being the neonates who suffered from perinatal asphyxia with Apgar < 7 at 1 minute of life. The spot urine sample was collected within 24 hours of birth and their uric acid and creatinine levels were measured and the ratio calculated. Asphyxiated neonates were classied according to Sarnat and Sarnat staging. We Compare UA/Cr ratio with Apgar score and HIE staging using Sarnat and Sarnat staging.Results: On comparison of UUA/Cr among cases and controls we found that ratio was signicantly higher in asphyxiated neonates as compared to non asphyxiate neonates. (Control vs. Cases Group: 2.4 ± 1 vs. 3.6 ± 1.5; p –value < 0.0001). On comparison of UUA/Cr among cases with Sarnat and Sarnat staging of HIE, there is a signicant difference observed in mean UA/Cr ratio across Sarnat and Sarnat staging of HIE (F – Value = 68.760; p – value = 0.0001). Conclusion: Urinary uric acid and creatinine ratio can be used as markers for perinatal asphyxia for screening in centers where other markers for assessing perinatal asphyxia are not available. Urinary uric acid and creatinine ratio is a non-invasive, cheap and easily available marker for assessing the severity perinatal asphyxia.

scholarly journals Study of urinary uric acid and creatinine ratio as a marker of neonatal asphyxia for babies born in a tertiary care hospital

2017 ◽  
Vol 5 (12) ◽  
pp. 5418 ◽  
Author(s):  
Elango Krishnana ◽  
Venmugil Ponnusamy ◽  
Sathiya Priya Sekar
Keyword(s):  
Uric Acid ◽  
Perinatal Asphyxia ◽  
Tertiary Care ◽  
Neonatal Morbidity ◽  
Cerebral Injury ◽  
Care Hospital ◽  
Creatinine Ratio ◽  
Spot Urine ◽  
Medical College ◽  
Non Invasive

Background: Perinatal asphyxia is a common neonatal problem and there is significant contribution to neonatal morbidity and mortality. It is regarded as an important and common cause of preventable cerebral injury. The prediction of perinatal asphyxial outcome is important but formidable. There is only a limited role for the Apgar score for predicting the immediate outcome, such as HIE and the long-term neurological sequelae observational error can happen in APGAR. But biochemical parameters can be truly relied upon. This study was to evaluate the utility of urinary uric acid to creatinine ratio (UA/CR ratio) as non-invasive, easy, cheap and at the same time early biochemical means of asphyxia diagnosis.Methods: In this prospective case control study conducted in KAPV Government medical college between Feb 2017 to Sept 2017, 100 asphyxiated and 100 non-asphyxiated newborns were included. Detailed history and assessment were for all the enrolled newborns. Spot urine samples were sent for uric acid and creatinine estimation. Results were recorded, and statistical analysis was done.Results: The mean Uric acid/Creatinine ratio in the cases and controls groups were 2.58±1.09 and 0.86±0.17 respectively. The ratio also correlated well with the stage of HIE.Conclusions: The ratio of UA/Cr enables early and rapid recognition of asphyxial injury and also the assessment of its severity and the potential for short term morbidity or death.

scholarly journals The value of urinary uric acid and creatinine ratio in neonatal asphyxia

2020 ◽  
Vol 7 (8) ◽  
pp. 425-429
Author(s):  
Dr. Nikhil Gupta ◽  
◽  
Dr. Alka Bhambri ◽  
Dr. Vedika A Bhat ◽  
Dr. Rashmi Katyal ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cord Blood ◽  
Prospective Observational Study ◽  
Umbilical Artery ◽  
Perinatal Asphyxia ◽  
Significant Negative Correlation ◽  
Creatinine Ratio ◽  
Spot Urine ◽  
Neonatal Asphyxia ◽  
One Year

Objective: The value of urinary uric acid and creatinine ratio in neonatal asphyxia. Method: This was a prospective observational study conducted over one year, on 45 newborns admitted in NICU with perinatal asphyxia. Cord blood from the umbilical artery was sent for pH analysis and urinary uric acid and creatinine levels were estimated in spot urine samples. Results: The urinary uric acid and creatinine ratio had a positive correlation with low APGAR scores at the 1st and 5th minute. Also, urinary uric acid to creatinine ratios was significantly higher in infants with severe HIE (3.18±0.61) when compared with infants of moderate HIE (2.19±0.32). It showed a significant negative correlation with pH of cord blood in neonates with perinatal asphyxia. Conclusion: The urinary uric acid and creatinine ratio can be used as a supportive diagnostic test for early diagnosis of perinatal asphyxia.

scholarly journals Urinary uric acid to creatinine ratio as a marker of perinatal asphyxia and its correlation with arterial blood gas values

2021 ◽  
Vol 29 (3) ◽  
pp. 238-244
Author(s):  
Priya Sharma ◽  
Krishnaswami Devimeenakshi
Keyword(s):  
Uric Acid ◽  
Cord Blood ◽  
Roc Curve ◽  
Perinatal Asphyxia ◽  
Creatinine Ratio ◽  
Blood Gas ◽  
Apgar Scores ◽  
Arterial Blood Gas ◽  
Arterial Blood ◽  
Normal Neonates

Objective Perinatal asphyxia is a leading cause of neonatal morbidity and mortality in developing countries. Lack of facilities like arterial blood gas analysis in resource limited settings warrants cost effective methods to support the diagnosis of asphyxia. The study objectives were to evaluate the utility of urinary uric acid to creatinine ratio (UA/Cr ratio) as a marker of perinatal asphyxia and to ascertain its correlation with cord blood arterial blood gas values. Methods It was a prospective comparative study where cases and controls were of asphyxiated neonates and normal neonates respectively delivered in a tertiary care medical college hospital from April 2019 to September 2019. Urinary UA/Cr ratio and its correlation with Apgar score was determined. The ability to predict asphyxia was estimated by ROC curve and p<0.05 was considered as statistically significant. Results Data from 38 asphyxiated and 38 normal neonates were analyzed. The mean urinary UA/Cr ratio was higher in the asphyxiated babies. There was negative correlation between urinary UA/Cr ratio and pH, pO2, Apgar scores and positive correlation with pCO2. The urinary UA/Cr ratio had excellent predictive validity for perinatal asphyxia determined by ROC curve. The urinary uric acid /creatinine ratio had sensitivity of 92.11% and specificity was 92.11%. Conclusion Urinary uric acid to creatinine ratio correlated well with the cord blood arterial blood gas values and the Apgar scores. This study showed that there is a significant increase in the urinary UA/Cr ratio in asphyxiated neonates and it can be used as a biochemical marker of perinatal asphyxia.

scholarly journals Correlation between Apgar score and urinary uric acid to creatinine ratio in perinatal asphyxia

2008 ◽  
Vol 23 (4) ◽  
pp. 361-364 ◽  
Author(s):  
Pallab Basu ◽  
Sabyasachi Som ◽  
Nabendu Choudhuri ◽  
Harendranath Das
Keyword(s):  
Uric Acid ◽  
Apgar Score ◽  
Perinatal Asphyxia ◽  
Creatinine Ratio
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