Colostrum as a Therapeutic: A Meta Review

This meta-review is an examination of the therapeutic properties of colostrum. The scientific development and subsequent implementation of new therapeutics continues to influence researchers all over the globe today. Therefore, this review examines previously published research on colostrum and its effects on physiological functioning to determine its role as a potential therapeutic. Additionally, this review explores options for the potential therapeutic use of colostrum in immunology, IBS, diabetes and thyroid. There is abundant research supporting the immunomodulatory properties of colostrum, while also implicating its roles in alleviating IBS which is presented in this review. There is also evidence for the presence of IGF-1, T4, T3 and iodine in colostrum. Therefore, this review will also examine the current research examining the detection and respective physiological relevance for diabetes and thyroid functioning.

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Therapeutic Use of Mesenchymal Stromal Cells: The Need for Inclusive Characterization Guidelines to Accommodate All Tissue Sources and Species

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2021.632717 ◽

2021 ◽

Vol 9 ◽

Author(s):

Adrienne Wright ◽

Marne L. Arthaud-Day ◽

Mark L. Weiss

Keyword(s):

Mesenchymal Stromal Cells ◽

Stromal Cells ◽

Standard Of Care ◽

The United States ◽

Therapeutic Use ◽

Therapeutic Modality ◽

Common Goal ◽

Immunomodulatory Properties ◽

Clinical Trial Results

Following their discovery over 50 years ago, mesenchymal stromal cells (MSCs) have become one of the most studied cellular therapeutic products by both academia and industry due to their regenerative potential and immunomodulatory properties. The promise of MSCs as a therapeutic modality has been demonstrated by preclinical data yet has not translated to consistent, successful clinical trial results in humans. Despite the disparities across the field, MSC shareholders are unified under one common goal—to use MSCs as a therapeutic modality to improve the quality of life for those suffering from a malady in which the standard of care is suboptimal or no longer effective. Currently, there is no Food and Drug Administration (FDA)-approved MSC therapy on the market in the United States although several MSC products have been granted regulatory approval in other countries. In this review, we intend to identify hurdles that are impeding therapeutic progress and discuss strategies that may aid in accomplishing this universal goal of widespread therapeutic use.

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Immunomodulatory properties of human recombinant lactoferrin in mice: Implications for therapeutic use in humans

Advances in Clinical and Experimental Medicine ◽

10.17219/acem/68440 ◽

2018 ◽

Vol 27 (3) ◽

pp. 391-399

Author(s):

Jolanta Artym ◽

Maja Kocięba ◽

Ewa Zaczyńska ◽

Barbara Adamik ◽

Andrzej Kübler ◽

...

Keyword(s):

Therapeutic Use ◽

Immunomodulatory Properties

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VANGA IN AYURVEDA - A LITERARY REVIEW

November 2020 - International Ayurvedic Medical Journal ◽

10.46607/iamj3608092020 ◽

2020 ◽

Vol 8 (9) ◽

pp. 4520-4527

Author(s):

Parween Bano ◽

Sakhitha K. S ◽

K. Shankar Rao

Keyword(s):

Melting Point ◽

Therapeutic Use ◽

Drug Of Choice ◽

Therapeutic Properties

Regarding the use of metals (Dhatu), history observation reveals that India was the first country to start the use of Vanga for various industrial, alchemical and therapeutic purposes. The word Trapu is mentioned regarding Vanga in Veda and Samhita. In Brihatrayi, external and internal use of Vanga is found with ref-erence to ‘Suvarna Samala Pancha Loha’, ‘Bhouma Dravyas’ etc. In Rasa classics, Vanga and its thera-peutic properties have been widely described under Puti Loha the metal which emit obnoxious smell, while they are melting. Rasa scholars mentioned its synonyms like Vanga, Picchata, Shukraloha etc which de-notes its distribution, physical and therapeutic properties. One of the properties of Vanga is Drutdravam i.e. melt at low heat which proves by its low melting point (2320C). On observing various literature, it is seen that in Samhita, only therapeutic use of mentioned. But in Rasashastra, its types, Pharmaceutical pro-cess like Shodhana, Jarana, Marana and use in alchemical and therapeutic purposes are described widely. Much importance has been given to its efficacy and told that ‘as lion destroy the group of elephants, like wise Vanga destroy all types of Meha Roga’. The author of Ayurveda Prakash has indicated that for Prameha Roga (diabetes), Vanga Bhasma is a drug of choice which is also evaluate by various research works on Vanga Bhasma.

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Advances in Microprobe Analysis Applied to Muscle, Nerve and Gland

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100054601 ◽

1982 ◽

Vol 40 ◽

pp. 404-407

Author(s):

T. E. Hutchinson ◽

D. E. Johnson ◽

A. C. Lee ◽

E. Y. Wang

Keyword(s):

Biological Tissue ◽

Microprobe Analysis ◽

Physiological State ◽

External Environment ◽

Physiological Relevance ◽

Muscle Nerve ◽

Technique Development

Microprobe analysis of biological tissue is now in the end phase of transition from instrumental and technique development to applications pertinent to questions of physiological relevance. The promise,implicit in early investigative efforts, is being fulfilled to an extent much greater than many had predicted. It would thus seem appropriate to briefly report studies exemplifying this, ∿. In general, the distributions of ions in tissue in a preselected physiological state produced by variations in the external environment is of importance in elucidating the mechanisms of exchange and regulation of these ions.

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Evaluation of Special Hearing Aids for Deaf Children

Journal of Speech and Hearing Disorders ◽

10.1044/jshd.3604.527 ◽

1971 ◽

Vol 36 (4) ◽

pp. 527-537 ◽

Cited By ~ 1

Author(s):

Norman P. Erber

Keyword(s):

Hearing Aids ◽

High Frequency ◽

Hearing Aid ◽

Low Frequency ◽

Acoustic Stimulation ◽

Deaf Children ◽

Frequency Range ◽

Frequency Limit ◽

Unpublished Studies ◽

Published Research

Two types of special hearing aid have been developed recently to improve the reception of speech by profoundly deaf children. In a different way, each special system provides greater low-frequency acoustic stimulation to deaf ears than does a conventional hearing aid. One of the devices extends the low-frequency limit of amplification; the other shifts high-frequency energy to a lower frequency range. In general, previous evaluations of these special hearing aids have obtained inconsistent or inconclusive results. This paper reviews most of the published research on the use of special hearing aids by deaf children, summarizes several unpublished studies, and suggests a set of guidelines for future evaluations of special and conventional amplification systems.

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Research Consumerism 101: Evaluating External Evidence of Treatment Effectiveness

Perspectives on Swallowing and Swallowing Disorders (Dysphagia) ◽

10.1044/sasd17.2.43 ◽

2008 ◽

Vol 17 (2) ◽

pp. 43-49

Author(s):

James L. Coyle

Keyword(s):

Treatment Effectiveness ◽

Code Of Ethics ◽

Oropharyngeal Dysphagia ◽

Clinical Importance ◽

Professional Services ◽

Adverse Outcomes ◽

Professional Judgment ◽

Evidence Based ◽

Intervention Selection ◽

Published Research

Abstract The modern clinician is a research consumer. Rehabilitation of oropharyngeal impairments, and prevention of the adverse outcomes of dysphagia, requires the clinician to select interventions for which evidence of a reasonable likelihood of a successful, important outcome exists. The purpose of this paper is to provide strategies for evaluation of published research regarding treatment of oropharyngeal dysphagia. This article utilizes tutorial and examples to inform and educate practitioners in methods of appraising published research. It provides and encourages the use of methods of efficiently evaluating the validity and clinical importance of published research. Additionally, it discusses the importance of the ethical obligation we, as practitioners, have to use evidence-based treatment selection methods and measurement of patient performance during therapy. The reader is provided with tactics for evaluating treatment studies to establish a study's validity and, thereby, objectively select interventions. The importance of avoiding subjective or unsubstantiated claims and using objective methods of generating empirical clinical evidence is emphasized. The ability to evaluate the quality of research provides clinicians with objective intervention selection as an important, essential component of evidence-based clinical practice. ASHA Code of Ethics (2003): Principle I, Rule F: “Individuals shall fully inform the persons they serve of the nature and possible effects of services rendered and products dispensed…” (p. 2) Principle I, Rule G: “Individuals shall evaluate the effectiveness of services rendered and of products dispensed and shall provide services or dispense products only when benefit can reasonably be expected.” (p. 2) Principle IV, Rule G: “Individuals shall not provide professional services without exercising independent professional judgment, regardless of referral source or prescription.” (p. 4)

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