scholarly journals Case Report: Risperidone Induced Peripheral Edema

2021 ◽  
pp. 25-28
Author(s):  
Farzana Faruki ◽  
Uma Datta Gupta ◽  
Adeel Anwar ◽  
Saral Desai
Keyword(s):  
Case Reports ◽  
Leg Pain ◽  
Type I ◽  
Patient Counseling ◽  
Atypical Depression ◽  
Medication Discontinuation ◽  
History Of ◽  
Bipolar Type ◽  
Leg Edema

Risperidone is the first line of treatment for bipolar disorder, atypical depression, and Schizophrenia. We present a 55-year-old male with a history of schizoaffective disorder with bipolar type I presented with aggressive behavior and suicidal ideation. Our patient was treated with low-dose Risperidone; after that, he gradually developed leg pain and edema. His leg pain hampers his ambulation, which is clinically improved after a week of medication discontinuation; however, his leg edema did not resolve completely. In addition, we evaluated our patient's compliance with an empathic verbal interview that shows edema and leg pain hampers his quality of life. We have found that not informing edema as one of the possible side effects increases medication non-compliance in our case. There are several case reports about the side effect of Risperidone (such as leg edema) in combination with other medications, but there is no recommendation about patient counseling of forthcoming leg edema and mobility issues.

Quality of life in bipolar type I disorder and schizophrenia in remission: Clinical and neurocognitive correlates

2008 ◽  
Vol 160 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Sofia Brissos ◽  
Vasco Videira Dias ◽  
Ana Isabel Carita ◽  
Anabel Martinez-Arán
Keyword(s):  
Quality Of Life ◽  
Type I ◽  
Bipolar Type

scholarly journals Osteopetrosis. Presentación de dos casos [Non-surgical management of osteopetrosis: two case reports an review of the literature]

2019 ◽  
Vol 84 (4) ◽  
pp. 386-392
Author(s):  
Juan Carlos Caruso ◽  
Juan Martín Patiño
Keyword(s):  
Surgical Treatment ◽  
Case Reports ◽  
Bone Dysplasia ◽  
Invasive Treatment ◽  
Non Invasive ◽  
History Of ◽  
Diaphyseal Fractures ◽  
Non Surgical Treatment ◽  
Delayed Consolidation

Las osteopetrosis (enfermedad de Albers-Schönberg) es un síndrome con cuatro tipos clásicos e instituye una displasia ósea secundaria a la falta de resorción de hueso por anormalidad de los osteoclastos, lo cual provoca un tejido óseo duro y quebradizo,propenso a fracturas difíciles de tratar quirúrgicamente. Se han publicado escasos artículos sobre el tema; por este motivo, decidimos presentar a dos pacientes con fracturas diafisarias de húmero con osteopetrosis, ambas tratadas en forma incruenta.Los objetivos son comunicar nuestra experiencia y el método de tratamiento de dicha afección y realizar una revisión bibliográfica acerca del tema. Creemos que el tratamiento de elección para las fracturas diafisarias de húmero en pacientes con osteopetrosises el incruento, ya que su tipo de tejido óseo dificulta la implementación de cualquier osteosíntesis. Además, la colocación de implantes puede provocar algunas complicaciones, como infecciones, retraso de la consolidación y seudoartrosis. La cirugía se reserva para ciertos casos, como en pacientes con riesgo de desarrollar deformidades incapacitantes, aquellos que han sufrido fracturas repetidas, con retraso de la consolidación, seudoartrosis, quienes no responden al tratamiento incruento o con unadeformidad previa.AbstractOsteopetrosis (also known as Albers-Schönberg disease) is a syndrome that includes four classic types and is characterized by bone dysplasia and lack of bone resorption due to abnormal osteoclastic activity and consequent development of brittle and hard bone that is prone to fractures that are difficult to treat surgically. Herein we present two cases of osteopetrosis with diaphyseal fractures of the humerus, both managed with non-surgical treatment. The objectives of our manuscript are to document our experience in the management of these cases and review the literature. The non-invasive treatment provides the best outcome for dyaphyseal fractures on the humerus in patients with osteopetrosis, given that the quality of the bone in these patients impairs the implementation of osteosynthesis. In addition, the placement of implants can lead to complications such as infections, delayed consolidation and pseudoarthrosis, among others. Surgical treatment should reserved for certain patients such as those with delayed consolidation, pseudoarthrosis, a history of repeated fractures, pre-existing deformity and those who are at risk for the development of disabling deformities or do not respond to non-surgical treatment.

History of suicide attempts in patients with bipolar disorder type I: socio-demographic and clinical factors, quality of life and functioning

2020 ◽  
pp. 1-8
Author(s):  
Vitor Fernandes de Almeida ◽  
Severino Bezerra-Filho ◽  
Paula Studart-Bottó ◽  
Gabriela Léda-Rego ◽  
Ivã Taiuan Fialho Silva ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Bipolar Disorder ◽  
Suicide Attempts ◽  
Type I ◽  
Clinical Factors ◽  
History Of ◽  
Disorder Type

scholarly journals Type I split cord malformation and tethered cord syndrome in an adult patient: A case report and literature review

2019 ◽  
Vol 10 ◽  
pp. 90
Author(s):  
Erin N. D’Agostino ◽  
Daniel R. Calnan ◽  
Vyacheslav I. Makler ◽  
Imad Khan ◽  
John H. Kanter ◽  
...  
Keyword(s):  
Conservative Therapy ◽  
Tethered Cord ◽  
Tethered Cord Syndrome ◽  
Leg Pain ◽  
Split Cord Malformation ◽  
Type I ◽  
Review Of Literature ◽  
History Of ◽  
Magnetic Resonance Imaging Mri

Background: In a split cord malformation (SCM), the spinal cord is divided longitudinally into two distinct hemicords that later rejoin. This can result in a tethered cord syndrome (TCS). Rarely, TCS secondary to SCM presents in adulthood. Here, we present an adult female with Type I SCM resulting in TCS and a review of literature. Case Description: A 57-year-old female with a history of spina bifida occulta presented with a 2-year history of worsening back and left leg pain, difficulty with ambulation, and intermittent urinary incontinence; she had not responded to conservative therapy. Magnetic resonance imaging (MRI) revealed a tethered cord secondary to lumbar type I SCM. The patient underwent an L1–S1 laminectomy for resection of the bony septum with cord detethering. At 2-month follow-up, the patient had improvement in her motor symptoms and less pain. In literature, 25 cases of adult-onset surgically managed SCM with TCS were identified (between 1936 and 2018). Patients averaged 37 years of age at the time of diagnosis, and 56% were female. Conclusion: TCS can present secondary to SCM in adulthood and is characterized predominantly by back and leg pain.

scholarly journals Monopolar and Bipolar Combination Injuries of the Clavicle: Retrospective Incidence Analysis and Proposal of a New Classification System

2021 ◽  
Vol 10 (24) ◽  
pp. 5764
Author(s):  
Mustafa Sinan Bakir ◽  
Roman Carbon ◽  
Axel Ekkernkamp ◽  
Stefan Schulz-Drost
Keyword(s):  
Case Reports ◽  
Clavicle Fracture ◽  
Type I ◽  
Type Ii ◽  
New Classification ◽  
Joint Dislocations ◽  
Type Ia ◽  
Icd 10 ◽  
Bipolar Type ◽  
Incidence Analysis

Clavicle injuries are common, but only few case reports describe combined clavicular injuries (CCI). CCI include combinations between clavicular fractures and acromioclavicular/sternoclavicular joint dislocations (SCJD). We present the first general therapeutic recommendations for CCI based on a new classification and their distribution. A retrospective, epidemiological, big data analysis was based on ICD-10 diagnoses from 2012 to 2014 provided by the German Federal Statistical Office. CCI represent 0.7% of all clavicle-related injuries (n = 814 out of 114,003). SCJD show by far the highest proportion of combination injuries (13.2% of all SCJD were part of CCI) while the proportion of CCI in relation to the other injury entities was significantly less (p < 0.023). CCIs were classified depending on (1) the polarity (monopolar type I, 92.2% versus bipolar type II, 7.8%). Monopolar type I was further differentiated depending on (2) the positional relationship between the combined injuries: Ia two injuries directly at the respective pole versus Ib with an injury at one end plus an additional midshaft clavicle fracture. Type II was further differentiated depending on (3) the injured structures: IIa ligamento-osseous, type IIb purely ligamentous (rarest with 0.6%). According to our classification, the CCI severity increases from type Ia to IIb. CCI are more important than previously believed and seen as an indication for surgery. The exclusion of further, contra-polar injuries in the event of a clavicle injury is clinically relevant and should be focused.

scholarly journals Atrio-ventricular Block Following Neostigmine-Glycopyrrolate Reversal in Non-heart Transplant Patients: Case Report

2018 ◽  
Vol 65 (3) ◽  
pp. 187-191 ◽  
Author(s):  
Njinkeng J. Nkemngu ◽  
Joel N. Tochie
Keyword(s):  
Case Reports ◽  
Neuromuscular Block ◽  
Neuromuscular Blocking ◽  
Type I ◽  
Simultaneous Administration ◽  
Av Block ◽  
Dental Surgery ◽  
Transplant Patients ◽  
History Of ◽  
Anticholinesterase Drug

Neostigmine is the anticholinesterase drug most commonly used to reverse blockade or speed up recovery from neuromuscular blockade from nondepolarizing neuromuscular blocking drugs. Because of its cardiac muscarinic effects, prior or simultaneous administration of glycopyrrolate or atropine is usually recommended. There have been a few case reports of bradycardia, atrio-ventricular (AV) block, and cardiac arrest following neostigmine/glycopyrrolate administration to reverse neuromuscular block affecting several patients. In this report, we describe a case of 21-year-old with a history of seizure disorder and developmental delay that presented for dental surgery under general anesthesia and developed type I AV block following the simultaneous administration of neostigmine and glycopyrrolate to reverse a nondepolarizing neuromuscular block with rocuronium at the end of his surgery. We suggest that the chronic use of antiepileptic drugs in this patient in combination with neostigmine and glycopyrrolate lead to AV block in this patient. We also review similar cases reported in the literature and suggest an explanation for this observed phenomenon.

Abnormal dose-response melatonin suppression by light in bipolar type I patients compared with healthy adult subjects

2009 ◽  
Vol 21 (5) ◽  
pp. 246-255 ◽  
Author(s):  
Karen T. Hallam ◽  
Denovan P. Begg ◽  
James S. Olver ◽  
Trevor R. Norman
Keyword(s):  
Healthy Adult ◽  
Bipolar Affective Disorder ◽  
Face Validity ◽  
Type I ◽  
Melatonin Suppression ◽  
Light Intensities ◽  
History Of ◽  
Bipolar Type ◽  
Compare And Contrast ◽  
Adult Volunteers

Objective:Among potential endophenotypes proposed for bipolar affective disorder focusing on circadian abnormalities associated with the illness has particularly high face validity. Melatonin sensitivity to light is one circadian endophenotype proposed as useful in bipolar disorder. The aim of this study was to investigate melatonin sensitivity to light over a range of light intensities in order to compare and contrast responses in bipolar I patients with those of healthy adult volunteers.Methods:The study included seven patients (4 females, 3 males) with bipolar I disorder and 34 control participants (22 females, 12 males) with no personal or family history of affective illness. Melatonin sensitivity to light was determined in all patients and participants across a range of light intensities (0, 200, 500 and 1000 lux).Results:The results indicated that patients showed melatonin super-sensitivity to light in comparison with controls, a response that was consistent across the entire light intensity range investigated.Conclusion:The study provides further evidence for a super sensitive response in bipolar I patients and suggests that its potential usefulness as an endophenotypic marker of the illness is deserving of further research.

Use of immunocytology to predict bladder cancer presence in patients with asymptomatic hematuria.

2011 ◽  
Vol 29 (7_suppl) ◽  
pp. 242-242
Author(s):  
E. K. Cha ◽  
L. Tirsar ◽  
S. F. Shariat ◽  
P. J. Christos ◽  
M. Mazumdar ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Predictive Accuracy ◽  
Smoking Status ◽  
Multivariable Analysis ◽  
Urothelial Cells ◽  
Patient Counseling ◽  
History Of ◽  
Sensitivity Specificity ◽  
Strong Independent Predictor

242 Background: The uCyt immunocytology assay detects cellular biomarkers for bladder cancer (BCa) in exfoliated urothelial cells. We assessed the performance of uCy for detecting BCa in patients undergoing initial evaluation for asymptomatic hematuria. Methods: Data from 1,182 subjects without a history of BCa undergoing evaluation for hematuria were collected at three centers: EuromedClinic/Urologie24, University of Tübingen, and Central Hospital of Bolzano. All subjects underwent standard workup (i.e., voided cytology, upper tract imaging, and cystoscopy) and immunocytology. Results: Overall, 245 subjects had BCa (20.7%). The sensitivity/specificity/negative predictive value for uCyt and cytology were 82.4%/86.6%/95.0% and 46.5%/94.9%/87.2%, respectively. uCyt (OR 18.3, p<0.001) and cytology (OR 2.9, p<0.001) were associated with BCa in a multivariable analysis. The base model (age, gender, smoking status, type of hematuria) predicted BCa with an accuracy of 74.1%. Addition of cytology to the base model improved predictive accuracy (PA) to 83.5% (p<0.001), while addition of uCyt to the base model improved PA to 90.1% (p<0.001). Addition of uCyt to Model 1 significantly improved PA (+7.6%, p<0.001), but addition of cytology to Model 2 did not (+1.0%, p=0.057). uCyt performed equally well in patients with microscopic and gross hematuria (OR 30 vs. 27), while cytology did not (OR 18 vs. 12). Conclusions: uCyt is a strong, independent predictor of BCa in patients with hematuria; it outperforms cytology. uCyt may help with patient counseling, quality of care optimization (referral prioritization), and possibly sparing unnecessary hematuria workup in patients at extremely low risk of BCa. [Table: see text] No significant financial relationships to disclose.

scholarly journals Spondylocostal Dysostosis: A Literature Review and Case Report with Long-Term Follow-Up of a Conservatively Managed Patient

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Brendan R. Southam ◽  
Adam P. Schumaier ◽  
Alvin H. Crawford
Keyword(s):  
Quality Of Life ◽  
Natural History ◽  
Chronic Back Pain ◽  
Treated Patient ◽  
Case Reports ◽  
Spondylocostal Dysostosis ◽  
Wide Range ◽  
History Of

Introduction. Patients with spondylocostal dysostosis (SCD) have congenital spine and rib deformities associated with frequently severe thoracic insufficiency and respiratory compromise. The literature is largely composed of case reports and small cohorts, and there is little information regarding adults with this condition. In this report, we describe the natural history of a conservatively treated patient and include quality-of-life issues such as childbearing, athletic participation, and occupational selection. Case Presentation. We present a patient with SCD who was conservatively treated by a single physician from birth for 31 years. Our patient was capable of a reasonably good quality of life through adulthood, including participation in gymnastics and employment. At age 18, she became pregnant and subsequently terminated the pregnancy due to obstetrical concerns for compromised respiration. She has had intermittent respiratory complaints and occasionally experiences dyspnea with exertion, but this only has limited her during certain activities in the past three years. Currently, she takes naproxen for chronic back pain with periodic exacerbations. Discussion. Other cases in the literature have described adult SCD patients who have received nonoperative treatment and achieved a wide range of functional outcomes. This provides some limited evidence to suggest that select patients with SCD may be treated conservatively and achieve a reasonable quality of life. However, close clinical follow-up with these patients is recommended, particularly early on, considering the high rates of infant morbidity and mortality. Chest physiotherapy and early pulmonary care have been associated with favorable outcomes in infancy. Surgery to increase thoracic volume and correct scoliosis has been shown in some cases to improve respiratory function. Treatment depends on the degree of thoracic insufficiency and quality of life. The natural history of SCD remains largely unknown, but some patients are capable of relatively favorable life spans, employment, and participation in athletics.

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