scholarly journals Prevalence of Extended-Spectrum β-Lactamase and Antimicrobial Susceptibility Pattern of Clinical Isolates of Pseudomonas in Tertiary Care Centre of Kutch

2021 ◽  
pp. 45-49
Author(s):  
Krupali Kothari ◽  
Dolly Solanki
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Susceptibility ◽  
Tertiary Care ◽  
Medical Science ◽  
Clinical Samples ◽  
Zone Of Inhibition ◽  
Tertiary Care Centre ◽  
Antibiotic Policy ◽  
Antimicrobial Susceptibility Pattern ◽  
One Year

Aim: The current research was performed with an aim to discover the prevalence of ESBL producing P. aeruginosa and also to provide as a direct for doctors administration subjects by executing suitable infection control events as well as inventing an efficient antibiotic policy. Materials and Methods: The current research was performed in the Department of Microbiology at Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat over a period for one year. All 250 isolates of Pseudomonas aeruginosa acquired from different clinical samples established in microbiology laboratory from IPD & OPD were incorporated in the research. Different clinical specimens established in our laboratory were coursed and Pseudomonas aeruginosa was recognized as apiece normal microbiological method. All isolates were subjected for ESBL screening test. Antimicrobial susceptibility test was performed by Kirby. Results: Highest samples established from middle age group (30- 50). Out of 250 isolates, 177 (70.7%) isolates of Pseudomonas aeruginosa demonstrated zone of inhibition≤ 22 mm for Ceftazidime. All ESBL positive Pseudomonas aeruginosa isolates demonstrated elevated confrontation to ciprofloxacin 43 (91.04%), Gentamicin 34 (72.3%) and tobramycin 33 (70.21%). Conclusion: The majority of isolates were from hospitalized subjects which point out additional probability of their nosocomial predominance.

scholarly journals PREVALENCE AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF HIGH LEVEL AMINOGLYCOSIDE RESISTANCE AMONG GRAM POSITIVE ORGANISMS IN A TERTIARY CARE CENTRE

2021 ◽  
pp. 47-49
Author(s):  
DIVYA PRABHA A. ◽  
POOJA NAIR ◽  
S. S. M. UMAMAGESWARI ◽  
R. MONICA ◽  
ROSY VENNILA
Keyword(s):  
Antimicrobial Susceptibility ◽  
Tertiary Care ◽  
Clinical Samples ◽  
Enterococcus Species ◽  
Susceptibility Pattern ◽  
Tertiary Care Centre ◽  
Aminoglycoside Resistance ◽  
Gram Positive ◽  
Antimicrobial Susceptibility Pattern ◽  
High Level

Objective: The study is done to determine the prevalence and the antimicrobial susceptibility against the gram positive organisms with high level amino glycosides resistance. Methods: This is a prospective study involving the analysis of clinical samples for gram positive organisms like Streptococcus species, Enterococcus species and Staphylococcus species and determining their antimicrobial susceptibility pattern. Results: From the collected clinical samples, all the gram positive organisms show resistance to gentamicin. Most of the Staphylococcus species showed a wide resistance to erythromycin followed by ceftrioxazone and many Enterococcus species shows resistance to penicillin, erythromycin, ciprofloxacin. Conclusion: The high level aminoglycoside resistant (HLAR) gram positive organisms showed susceptibility to few drugs that are prevalent in various clinical samples. Surveillance of antimicrobial resistance and sensitivity is essential in managing and control of infection.

scholarly journals Prevalence and Antimicrobial Susceptibility Pattern of Pseudomonas aeruginosa Isolated from Various Clinical Samples in a Tertiary Care Hospital

2020 ◽  
Vol 8 (2) ◽  
pp. 11-17
Author(s):  
Surya Narayan Mahaseth ◽  
Lokeshwar Chaurasia ◽  
Brajesh Jha ◽  
Raj Kumari Sanjana
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Susceptibility ◽  
Tertiary Care Hospital ◽  
Chemotherapeutic Agent ◽  
Tertiary Care ◽  
Clinical Samples ◽  
Care Hospital ◽  
Susceptibility Pattern ◽  
Antimicrobial Susceptibility Pattern ◽  
Susceptibility Rate

Background and Objectives: Pseudomonas aeruginosa is one of the leading causes of hospital acquired infections. Increased resistance in this organism continues to pose a significant threat to patient care because of limited therapeutic options. The main objective of this study was to find out the prevalence and current antimicrobial susceptibility pattern of P. aeruginosa isolates obtained from various clinical samples at a tertiary care hospital. Material and Methods: The study was conducted in a tertiary care hospital in Bharatpur, Chitwan, Nepal on 453 isolates of Pseudomonas aeruginosa from various clinical samples. The colonies which were grown on culture media were identified by different standard biochemical tests. Antimicrobial susceptibility testing was done using Kirby–Bauer disc diffusion method and the results were interpreted according to the CLSI guidelines. Quality control of the test was done by standards ATCC strain of P. aeruginosa 27853. Results: This present study revealed the prevalence rate of P. aeruginosa was 11.29%. Piperacillintazobactam was the most sensitive chemotherapeutic agent with 94.26% susceptibility rate, followed by imipenem 89.40% and levofloxacin 88.08%. Amikacin showed better susceptibility rate 67.33% than that of gentamicin 48.78%; the susceptibility rate to cephalosporin and aztreonam was relative very low. Most of the P. aeruginosa strains were isolated from clinical samples like sputum 206, urine 81, respiratory secretion 76, and pus 35. Out of 453 clinical isolates, 167(36.86%) clinical isolates of P. aeruginosa were found to be MDR. Conclusion: Most of the P. aeruginosa strains were isolates from sputum, urine, respiratory secretions and pus samples and were found to be MDR. Piperacillin-tazobactam was the most sensitive chemotherapeutic agent followed by Imipenem, levofloxacin.

scholarly journals Antimicrobial Susceptibility Pattern of Klebsiella Species from Various Clinical Samples at a Tertiary Care Hospital

2020 ◽  
pp. 143-147
Author(s):  
K. Sathyavathy ◽  
B. Kiran Madhusudhan
Keyword(s):  
Antimicrobial Susceptibility ◽  
Tertiary Care ◽  
Diffusion Method ◽  
Clinical Samples ◽  
Care Hospital ◽  
Disc Diffusion ◽  
Susceptibility Pattern ◽  
Disc Diffusion Method ◽  
Klebsiella Species ◽  
Antimicrobial Susceptibility Pattern

The aim of the study was to investigate the antimicrobial susceptibility pattern of Klebsiella species from different clinical samples at Sree Balaji Medical College and Hospital, India. Overall 189 samples out of 980 non repetitive clinical samples obtained from wound/pus, urine, sputum swab and blood by disc diffusion method and identified as Klebsiella and analysed. Out of total 189 Klebsiella isolates, 76 out of 155 K. pneumoniae (49%) were resistant and none out of 34 Klebsiella oxytoca (0%) showed resistance to cefotaxime and ceftazidime by disc diffusion method. Antimicrobial susceptibility testing of Klebsiella exhibited 100% resistance to Ampicillin. The present study highlights the need for the continued monitoring of antimicrobial susceptibility patterns of important bacterial pathogens, so that rational antibiotic policies can be formulated.

scholarly journals PREVALENCE AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF PSEUDOMONAS SPECIES ISOLATED FROM CLINICAL SAMPLES IN A TERTIARY CARE HOSPITAL

2021 ◽  
pp. 50-53
Author(s):  
M. ABDUR RAHMAN ◽  
POOJA NAIR
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antimicrobial Susceptibility ◽  
Tertiary Care ◽  
Control Measures ◽  
Diffusion Method ◽  
Multi Drug Resistance ◽  
Clinical Samples ◽  
Care Hospital ◽  
Susceptibility Pattern ◽  
Pseudomonas Species

Objective: Pseudomonas aeruginosa is the commonest agent causing opportunistic nosocomial infections, contributing to mortality and morbidity worldwide. Along with its intrinsic and acquired resistance mechanisms, infections caused by Pseudomonas species further lead to treatment failure. This study was done to determine the prevalence and antimicrobial susceptibility pattern of different species of Pseudomonas isolated from various clinical samples by phenotypic methods. Methods: This study involved the examination of clinical samples for various species of Pseudomonas by using different standard biochemical tests. Their antimicrobial susceptibility profile was performed by the Kirby Bauer disc diffusion method. Analysis of the antibiogram pattern was done to study the multi-drug resistance among Pseudomonas species. Results: Out of the 1249 bacterial isolates, Pseudomonas species accounted for 12.9%. Pseudomonas species showed maximum resistance to gentamicin (31.4%), followed by ciprofloxacin (30.2%. and showed the least resistance tocolistin and polymyxin B. 46 isolates out of the 162 (28%) were found to be Multi-Drug Resistant (MDR) Pseudomonas aeruginosa. Conclusion: The present study highlights that Pseudomonas species remains a major cause of hospital-acquired infections. Multidrug resistance was observed in most of the strains, which makes the therapeutic options more difficult. Surveillance of antimicrobial resistance and strict infection control measures are essentially to be practiced in managing and control of infections caused by Pseudomonas.

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