scholarly journals Influence of Prostate Cancer on Erectile Dysfunction in Northern Cameroon and Its Management

2020 ◽  
pp. 7-15
Author(s):  
Richard Tagne Simo ◽  
Carmelle Noubissie Cheunieu ◽  
Mohamadou Ahmadou ◽  
Erika Myriam Baiguerel ◽  
Armel Hervé Nwabo Kamdje ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Erectile Dysfunction ◽  
Testosterone Levels ◽  
Health History ◽  
Survey Form ◽  
Northern Cameroon ◽  
History Of ◽  
Low Testosterone ◽  
Spontaneous Erection ◽  
The Impact

Due to the lack of hospitals with adequate technical platform on one hand, and high diagnostic costs that cannot be afforded most of the population, the incidence of prostate cancer in Cameroon has increased and has great impact on people’s health. Aim: This work was undertaken with the objective to determine the impact of prostate cancer on erectile dysfunction and how to manage it. Methodology: Sampling of the population was done in a comprehensive and non-probabilistic manner at the Urology Department of Ngaoundere Islamic Hospital, Ngaoundere, Cameroon, between June 2018 and November 2019. Of the 75 patients received, 50 of them participated in this study. Biopsies were taken from these patients to determine and confirm the form and stage of cancer followed by PSA assays. After the diagnosis was revealed, the testosterone assay was carried out in order to evaluate erectile functioning in the patients who equally completed a survey form made available to them in order to get an idea of their health history, the type of treatment followed and their lifestyle. Results: The mean age of the patients was 67 years, with a predominance in the 60-70 age range. 85% of the patients had a Gleason score greater than or equal to 8. Of these patients, 42% had low testosterone levels (< 2.3 ng/mL), resulting to lack of morning erection (66.6%), loss of sexual desire (43.9%), difficulty having a spontaneous erection (88%). On the other hand, erectile dysfunction was revealed in the prostate cancer patients with low testosterone levels, with a history of hypertention (16.6%), diabetes (28.5%) alcohol consumption (44%), tobacco smoking (41%) and having undergone as prostate cancer treatment involving transurethral resection of the prostate (80%) and orchiectomy (20%). Conclusion: The major cause of erectile dysfunction observed in patients suffering from prostate cancer in Northen Cameroon can be attributed to the evolution of the disease, as well as the health history of the patients (diabetes, hypertension).

scholarly journals Effect of prior cancer on survival outcomes for patients with advanced prostate cancer

BMC Urology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yechen Wu ◽  
Xi Chen ◽  
Duocheng Qian ◽  
Wei Wang ◽  
Yiping Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Outcomes ◽  
Cancer Diagnosis ◽  
Advanced Prostate Cancer ◽  
Lymphocytic Leukemia ◽  
Cancer History ◽  
Non Hodgkin Lymphoma ◽  
Kaplan Meier ◽  
History Of ◽  
The Impact

Abstract Background A history of prior cancer commonly results in exclusion from cancer clinical trials. However, whether a prior cancer history has an adversely impact on clinical outcomes for patients with advanced prostate cancer (APC) remains largely unknown. We therefore aimed to investigate the impact of prior cancer history on these patients. Methods We identified patients with advanced prostate cancer diagnosed from 2004 to 2010 in the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was used to balance baseline characteristics. Kaplan–Meier method and the Cox proportional hazard model were utilized for survival analysis. Results A total of 19,772 eligible APC patients were included, of whom 887 (4.5 %) had a history of prior cancer. Urinary bladder (19 %), colon and cecum (16 %), melanoma of the skin (9 %) malignancies, and non-hodgkin lymphoma (9 %) were the most common types of prior cancer. Patients with a history of prior cancer had slightly inferior overall survival (OS) (AHR = 1.13; 95 % CI [1.02–1.26]; P = 0.017) as compared with that of patients without a prior cancer diagnosis. Subgroup analysis further indicated that a history of prior cancer didn’t adversely impact patients’ clinical outcomes, except in patients with a prior cancer diagnosed within 2 years, at advanced stage, or originating from specific sites, including bladder, colon and cecum, or lung and bronchus, or prior chronic lymphocytic leukemia. Conclusions A large proportion of APC patients with a prior cancer history had non-inferior survival to that of patients without a prior cancer diagnosis. These patients may be candidates for relevant cancer trials.

Metabolic Syndrome in Men with Low Testosterone Levels: Relationship with Cardiovascular Risk Factors and Comorbidities and with Erectile Dysfunction

2013 ◽  
Vol 10 (10) ◽  
pp. 2529-2538 ◽  
Author(s):  
Eduardo García‐Cruz ◽  
Asier Leibar‐Tamayo ◽  
Javier Romero ◽  
Marta Piqueras ◽  
Pilar Luque ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Erectile Dysfunction ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Testosterone Levels ◽  
Low Testosterone

Earliest historic reference of ’tinnitus’ is controversial

2004 ◽  
Vol 118 (7) ◽  
pp. 487-488 ◽  
Author(s):  
S. Dietrich
Keyword(s):  
Ancient Egypt ◽  
Point Of View ◽  
Historical Period ◽  
Common Phenomenon ◽  
Original Source ◽  
The Past ◽  
Health History ◽  
History Of ◽  
The Impact ◽  
Modern Status

Tinnitus, that is defined as ’ringing in the ear’, is and has probably always been a very common phenomenon in the health history of mankind. A variety of pathomechanisms for its onset has been proposed in the past and this trend sees no stopping. Precise pathomechanisms still remain unclear. From the historical point of view, tinnitus is a very interesting topic but there is a lack of scientific enquiries. As its earliest historic reference, the Papyrus Ebers is often cited. By reviewing the original source, however, it is very unlikely that this contains the earliest historic reference of tinnitus. It is rather likely indeed that tinnitus was a known symptom in the ancient Egypt but it has never been exclusively been written down. This article reviews data provided by this fascinating historical period on the questionable reference and highlights the impact of history on the modern status of tinnitus.

scholarly journals A community-engaged protocol for evaluating environmental toxicants in a U.S. border community: the public health impacts of perchlorate and pesticide exposure (Preprint)

2019 ◽  
Author(s):  
Robert Trotter II ◽  
Julie Baldwin ◽  
Charles Loren Buck ◽  
Mark Remiker ◽  
Amanda Aguirre ◽  
...  
Keyword(s):  
Animal Model ◽  
Toxic Metal ◽  
Clinical Population ◽  
Metal Exposure ◽  
Mechanisms Of Toxicity ◽  
Health History ◽  
Access To Health ◽  
History Of ◽  
Local Water ◽  
The Impact

BACKGROUND The Northern Arizona University (NAU) Center for Health Equity Research (CHER) is conducting community-engaged health research “environmental toxicant scans” in the Yuma County (Yuma, Somerton, San Luis) regions in collaboration with community health stakeholders including the Yuma Regional Medical Center (YRMC), the Regional Center for Border Health, Inc. (RCBH), Campesinos sin Fronteras (CSF), the Yuma County Public Health District, and government agencies and NGO’s working on border health issues. OBJECTIVE We set out to construct a joint community/university effort to examine human exposures to the water-soluble contaminant perchlorate and to agricultural pesticides. This project includes development of a new animal model for investigation of mechanisms of toxicity following a “one health” approach. The ultimate goal of this community-engaged effort is to develop interventions to reduce exposures and health impacts of contaminants in Yuma populations. METHODS All participants completed the informed consent process, which included information on the purposes of the study, a request for access to health history and medical records data, and an interview. The interview included questions related to: 1) demographics, 2) social determinants of health, 3) health screening (e.g., family history of diseases), 4) occupation and environmental exposure to perchlorate and pesticides, and 5) access to health services. Each participant provided a hair sample for quantification of metals used in pesticides, a urine sample for perchlorate quantification, and a blood sample for endocrine assays. Data are modeled with measured levels of contaminants and hormones, and health status of the clinical population; data from the clinical population are compared to results from the general population. In parallel, an animal model for the impact of perchlorate and toxic metal exposure is being established through the collection of rodents that live near residences, farms, and local water sources. RESULTS We recruited, consented, enrolled, and surveyed 323 adults currently residing in Yuma County over a period of one year. One hundred and forty-seven residents are patients from either YRMC or RCBH with a primary diagnosis of thyroid disease, including hyperthyroidism, hypothyroidism, thyroid cancer, or goiter. The remaining 176 participants are from the general population but with no history of thyroid disorder. All participants completed the informed consent process, which included information on the purposes of the study, a request for access to health history and medical records data, and an interview. In parallel, an animal model for the impact of perchlorate and toxic metal exposure is being established through the collection of rodents that live near residences, farms, and local water sources. We are measuring perchlorate and toxic metals in tissues and examining the same health outcomes as with people (endocrine disruption), plus organ-specific histopathology, gene expression, and lipid accumulation. CONCLUSIONS Findings will elucidate mechanisms of toxicity and the population health effects of contaminants, as well as provide a new animal model to develop precision medicine capabilities for the population. CLINICALTRIAL not a clinical trial

scholarly journals The Impact of a Community Pharmacy Diabetes Self-Management Education Program on Diabetes Distress

2018 ◽  
Vol 35 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Morgan L. Machen ◽  
Hamilton C. Borden ◽  
Kenneth C. Hohmeier
Keyword(s):  
Community Pharmacy ◽  
Management Education ◽  
Information Age ◽  
Retrospective Chart Review ◽  
Self Management ◽  
Diabetes Distress ◽  
Health History ◽  
Scale Scores ◽  
History Of ◽  
The Impact

Background: Negative psychosocial implications stemming from the presence of diabetes, known as diabetes distress, place people with diabetes at twice the likelihood of having clinical depression than those who do not have the disease. While many community pharmacies have incorporated diabetes self-management education (DSME) programs into their practices, there are no known studies that evaluate the impact that this model may have on diabetes distress. Objective: The purpose of this study is to evaluate the impact that a community pharmacy DSME program has on diabetes distress. Methods: Retrospective chart review for pre- and post-DSME Problem Areas in Diabetes scale scores, pertinent health history (type and duration of diabetes, A1C, and medications), and demographic information (age, gender) of patients who completed Blount Discount Pharmacy’s DSME program. Data were analyzed using descriptive and inferential statistics. Results: Of the 17 charts that were reviewed, there was an overall decrease in Problem Areas in Diabetes scale scores from baseline ( P = .029). Greater reduction was observed in patients with a long-standing history of diabetes compared with those who were diagnosed with diabetes within the previous 12 months of DSME. Conclusions: The findings suggest that a community pharmacy DSME program may reduce diabetes distress and warrant future study.

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