scholarly journals Frequency of Gall Bladder Carcinoma among Patients of Cholelithiasis at Tertiary Care Hospital

2020 ◽  
pp. 20-24
Author(s):  
Mairaj Muhammad Khan ◽  
Agha Taj Mohammed ◽  
Rasool Bux Behan ◽  
Sohail Yousif
Keyword(s):  
Gall Bladder ◽  
Bladder Carcinoma ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Abdominal Ultrasound ◽  
Stone Disease ◽  
Care Hospital ◽  
Gall Bladder Carcinoma ◽  
Diagnostic Laboratory ◽  
Female Ratio

Objective: To determine the frequency of carcinoma of Gall Bladder in Hospitalized patients undergoing surgeries for cholelithiasis at tertiary care Hospital. Study Setting: General surgery department of Muhammad Medical College Mirpurkhas. Study Design: Descriptive.  Study Duration: From 2018 to 2019. Methodology: All the patients of cholelithiasis diagnosed via trans-abdominal ultrasound, those who underwent cholecystectomies and either of gender were included. After surgeries, specimens immediately were sent to the Hospital diagnostic laboratory to evaluate the gall bladder carcinoma. The information obtained was noted on a pre-designed proforma. Results: A total 200 patient of gall bladder stone disease were observed who underwent cholecystectomies. Average age was 53.8+5.62 years and male to female ratio was 1:2.5.  Incidence of carcinoma of gall bladder was 4%, which was significantly associated to gall bladder mass, chronic calculus cholecystitis and porcelain gall bladder (p=0.001).  Conclusion: The incidence of the gall bladder cancer in the study population was 4% and its relationship with gall bladder diseases (chronic cholecystitis and porcelain) was found to be significant.

scholarly journals Clinicopathological study of gall bladder carcinoma with special reference to its management in a tertiary care hospital

2020 ◽  
Vol 7 (12) ◽  
pp. 4120
Author(s):  
Debmalya Saha ◽  
Saket Jha ◽  
Sukalyan Chhaule ◽  
Rabin Mandal ◽  
Anadi Acharya ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Gallbladder Cancer ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Treatment Protocol ◽  
Rank Test ◽  
Common Symptom ◽  
Care Hospital ◽  
Female Ratio ◽  
Mortality And Morbidity

Background: Incidence of gallbladder carcinoma is increasing progressively among Indians and is regarded as a major cause of mortality and morbidity. In spite of this, limited studies have been conducted so far. Objective of the study was to know the prevalence, clinicopathological aspects, and prevalent treatment protocol of gall bladder cancer in a tertiary care hospital in Eastern India.Methods: 64 cases of histologically proven gallbladder cancer patients were studied. Patient characteristics were recorded using pretested proforma along with relevant investigations, and histopathology and treatment provided were recorded.Results: Our study reveals that gallbladder cancer has a prominent peak in the 7th decade of life with male: female ratio of 1:2.2. Most of the patients were having body mass index between 20.0 and 24.99, which is in sharp contrast to the available literatures. Pain is the most common symptom followed by constitutional symptoms. Majority of cases presented at advanced stage (64.1%) with significantly elevated CA19.9 level, and were managed with palliative chemotherapy.35.9% of our cases were respectable at the time of diagnosis, and extended cholecystectomy could be performed in 31.3%. Log rank test showed pattern of survival of the patients who were resected was significantly better than those of who were not resected.Conclusions: We know gallbladder cancer is a disease with very few patients amenable to surgery at the time of presentation. Thus, instead of retrospectively analyzing individual institutional data, high volume institutions with the necessary expertise for treating gallbladder cancer should collaborate with a view of generating strong evidence-based surgical guidelines.

scholarly journals Role of EGFR and HER-2/NEU Expression in Gall Bladder Carcinoma

2021 ◽  
Author(s):  
Chhanda Das ◽  
Madhumita Mukhopadhyay ◽  
Srijana Subba ◽  
Ashis Kumar Saha ◽  
Biswanath Mukhopadhyay
Keyword(s):  
Gall Bladder ◽  
Bladder Carcinoma ◽  
Tertiary Care ◽  
Molecular Therapy ◽  
Tumor Type ◽  
Care Hospital ◽  
Gall Bladder Carcinoma ◽  
Poorly Differentiated ◽  
Her 2 ◽  
Well Differentiated

Abstract Background Gall bladder carcinoma (GBC) is the most common malignancy of the biliary tract. Being known for its geographical and racial variations, and compared with the global statistics, its incidence is higher in the Indian subcontinent, mainly in the northern and eastern regions, accounting for 80 to 95% of cases. Aims and Objectives This study was conducted to evaluate the clinic-pathological spectrum and expression of EGFR and HER-2/NEU in GBCs and to understand their relation to prognosis, paving the way for targeted therapies for better treatment outcomes and patient survival. Materials and Methods This is a prospective study performed in a tertiary care hospital in 30 resected specimens of GBC cases recorded in our Department of Pathology from November 2017 to November 2019. Clinical history including the radiological reports and demographic parameters were included in the study pro forma. Immunohistochemical (IHC) staining for EGFR and HER-2/NEU was performed on all the selected cases. Clinicopathologic parameters like age, sex, histologic type, perineural, and lymphovascular invasion were compared and correlated with EGFR and HER-2/NEU status. Results Expression of EGFR was found in 93.33% of cases, which showed a highly significant correlation with histological tumor type (p = 0.000). HER-2/NEU expression was found in 56.66% of cases, which also showed a significant correlation with histological tumour type (p = 0.021). We found most of the cases with strong EGFR immunoreactivity (3+) were poorly differentiated tumors and most of the cases showing weak immunoreactivity for EGFR (1+) were well-differentiated. Conversely, in case of HER-2/NEU immunoreactivity, strong staining (3+) was seen in well-differentiated tumors and weak staining (1+) in poorly differentiated tumors. A significant correlation was also found between EGFR and HER-2/NEU expression (p = 0.000) and between cholelithiasis and EGFR expression (p = 0.033). Conclusion EGFR is expressed in most cases of GBC. Its expression is more in poorly differentiated carcinomas as compared to the well-differentiated carcinomas, whereas HER-2/NEU expression is more in well-differentiated carcinomas. Therefore, they may serve as independent prognostic factors and also as targets for molecular therapy in GBCs.

scholarly journals Association of gallbladder carcinoma with gallstone and its prevalence in a tertiary care teaching hospital

Mediscope ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 87-93
Author(s):  
Probir Kumar Sutradhar ◽  
Subrata Saha ◽  
Dipanwita Saha ◽  
Jharna Das ◽  
Sreejon Saha Anik ◽  
...  
Keyword(s):  
Gall Bladder ◽  
Gallbladder Carcinoma ◽  
Bladder Carcinoma ◽  
Tertiary Care ◽  
Stone Disease ◽  
Gall Bladder Carcinoma ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Malignant Lesions

Objective: To see the association of gallstones with gallbladder carcinoma and its prevalence in patients undergoing surgery for cholelithiasis. Methods: This cross-sectional observational study was conducted from July 2012 to June 2013 at the Department of Surgery, Mymensingh Medical College Hospital, Mymensingh with 150 cases of cholelithiasis. Results: Of 150 cases those were operated for gall bladder stone disease, 8 (eight) were found to have carcinoma of gall bladder i.e. prevalence was 5.3%. On ultrasound, only three (37.5%) patients were suspected as gall bladder carcinoma pre-operatively. Females are more affected than males by this disease. Also gall bladder carcinoma was found to be associated with single large-sized stone. Conclusion: The ultrasonography can miss a significant number of malignant lesions of the gall bladder in early stages and every cholecystectomy specimen should be examined histologically. Mediscope 2021;8(2): 87-93

scholarly journals Clinical and biochemical profile of obese and overweight children at a Tertiary Care Hospital.

2020 ◽  
Vol 27 (06) ◽  
pp. 1119-1123
Author(s):  
Asif Ali Khuhro ◽  
Fazal Ur Rehman ◽  
Waqas Ali ◽  
Najmi Usman ◽  
Sanam Bano Rajper
Keyword(s):  
Metabolic Syndrome ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Care Hospital ◽  
Biochemical Profile ◽  
Overweight Children ◽  
Cross Sectional ◽  
Female Ratio ◽  
Study Participants

Objectives: Childhood and adolescent obesity is increasing especially in developing countries like Pakistan. It seem to affect most socio-economic classes as well as all ethnicities and geographies. We planned this study to analyze the clinical and biochemical profile of obese as well as overweight children at a tertiary care hospital for the existence of metabolic syndrome. Study Design: Cross sectional study. Setting: Department of Pediatrics Medicine, Children Hospital Chandka Medical College / Shaheed Mohtarma Benazir Bhutto Medical University, Larkana. Period: 1st July 2018 to 31st December 2018. Material & Methods: Children, aged 5 to 16 years, both gender, having BMI > 85th percentile regarding age and gender were enrolled. Demographic characteristics along with history, lifestyle parameters and physical examination were noted for all the study participants. Metabolic syndrome (Met S) was evaluated while overall results were presented in terms of proportions, mean and standard deviations. Results: A total of 78 cases were enrolled during the study period. There were 46 (58.9%) male and 32 (41.1%) female, with a male to female ratio of 1.4:1. Mean age amongst study participants was 10.8 years. We had 56 (71.8%) children as overweight whereas 22 (28.2%) obese. Acanthosis nigricans was the most common entity seen in 55 (70.1%) children during clinical examination. Metabolic syndrome was found to be present in 31 (39.7%) participants. Conclusion: Met S is not only limited to obese children as it can also affect children who are overweight.

scholarly journals Changes in ECG among patients with drug induced poisoning in a tertiary care hospital

2019 ◽  
Vol 44 (3) ◽  
pp. 160-167 ◽  
Author(s):  
Ashraf Ur Rahman ◽  
AW Chowdhury ◽  
S Jabeen
Keyword(s):  
Qt Interval ◽  
Atrial Tachycardia ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Channel Blockers ◽  
Care Hospital ◽  
Ecg Changes ◽  
Drug Induced ◽  
Female Ratio ◽  
Pr Interval

Background: A wide variety of ECG changes can be seen with cardiac and noncardiac agents and may occur at therapeutic or toxic levels. Wide QRS and QT prolongation may be seen in poisoning cases; are potentially dangerous and indicate the necessity of continuous cardiac monitoring.The objective of this study was to determine the changes in ECG among patients admitted with pharmaceutical drug induced poisoning in a tertiary care hospital in Dhaka. Methods: This cross sectional study was carried out at the Department of Medicine, Dhaka Medical College Hospital (DMCH) during July-December, 2013. Detailed information were obtained; clinical examination and relevant investigations including ECG were done in each case according to protocol. Results: Among 66 cases mean age was 22.9 (±6.47) years and male to female ratio was 1: 2.14 (21 Vs 45). Common drug groups taken by the study population were benzodiazepines in 31(47.0%) and tricyclic antidepressants (TCA) in 18(27.3%) cases.Normal ECG findings were found in 28 (42.4%) cases, 18 (27.3%) cases revealed sinus tachycardia, 11(16.7%) showed prolong QT Interval, 6(9.1%) had atrial tachycardia, 5(7.6%) showed wide QRS and 3(4.6%) cases revealed prolong PR interval. Patients withTCA poisoning developedsinus tachycardia in 11(61.1%), prolong QT Interval in 6(33.3%), wide QRS in 5(27.8%),atrial tachycardia in 5(27.8%), prolong PR Interval in 2(11.1%), and Tall R in aVRin 2(11.1%) cases. Prolong QT Interval were found among 3 (75.0%) patients with K+ efflux channel blockers (chlorpromazine, chlorpheniramine and quetiapine) overdose.Patients with beta blocker overdose developed sinus bradycardia in 4 (100.0%) and prolong PR Interval in 1(25.0%) cases. Conclusion: Common drugs taken by the patients were amitriptyline sedatives. Wide QRS, prolong QT interval and some other ECG changes were observed by TCA poisoning in higher doses. TCA, benzodiazepines and K channel blockers induced prolong QT Interval in higher doses.Careful interpretation of ECG findings can provide key information to guide management of the poisoned patients. Bangladesh Med Res Counc Bull 2018; 44: 160-167

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