scholarly journals Study of Mortality and Morbidity in Neonates with Congenital Diaphragmatic Hernia

2021 ◽  
pp. 277-282
Author(s):  
Zainab Elahi ◽  
Seyyed Abolfazl Afje ◽  
Mohammad Kazemian ◽  
Maryam Shariati ◽  
Naeeme Taslimi Taleghani ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Analytical Study ◽  
Place Of Birth ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Relationship Of ◽  
The Relationship ◽  
Type Of Delivery

Introduction: Congenital diaphragmatic hernia may either lead to death or cause several complications such as increased pulmonary artery pressure. Objective: The present study aimed to compare mortality and morbidity, vasopressor intake, and visceral hernia of CDH neonates with pulmonary hypertension and without pulmonary hypertension in Mahdieh and Mofid hospitals in Tehran. Methods: This cross-sectional analytical study included 56 neonates with congenital diaphragmatic hernia who were admitted to Mofid and Mahdieh Children's Hospitals from 2014 to 2018. The sample size included 56 people selected based on census method. We compared the pulmonary hypertension and non-pulmonary hypertension groups in variables, such as gender, gestational age, birth weight, place of birth, and type of delivery and we examined relationship between pulmonary hypertension and mortality and morbidity and relationship between mortality and vasopressor intake. Results: The OR value was calculated to be 1.106, which is significant at the level of 0.004 (p < 0.01). This finding indicated that the chance of death in the group of infants with severe pulmonary hypertension was increased by 1.106. Also, the relationship of visceral hernia (stomach, intestine, liver, kidney, and spleen) to thorax was examined by logistic regression. Only the OR value of liver hernia (9.42) was significant (p < 0.001), indicating that the chance of death was higher in infants with liver hernias. It also the OR value of dopamine, dobutamine, and milrinone was significant (p < 0.01). Conclusion: In general, the results obtained in our study indicated that the mortality rate in the group of infants with pulmonary hypertension was significantly higher than the group without pulmonary hypertension. Also, liver hernia to thorax was associated with the severity of pulmonary hypertension, and the patients needed medication had a higher chance of death.

scholarly journals HUBUNGAN ANTARA PENGETAHUAN IBU TENTANG GIZI DENGAN STATUS GIZI ANAK UMUR 1- 3 TAHUN DI DESA MOPUSI KECAMATAN LOLAYAN KABUPATEN BOLAANG MONGONDOW INDUK SULAWESI UTARA

2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Murty Ekawaty M ◽  
Shirley E. S. Kawengian ◽  
Nova H. Kapantow
Keyword(s):  
Nutritional Status ◽  
Analytical Study ◽  
Maternal Nutrition ◽  
Cross Sectional ◽  
Spearman's Rho ◽  
Spearman’S Rho ◽  
Cross Sectional Design ◽  
Nutritional Status Of Children ◽  
Relationship Of ◽  
The Relationship

Abstract: This study aimed to determine the relationship between mothers' knowledge about nutrition and nutritional status of children aged 1-3 years in the Mopusi village, Lolayan Bolang Mongondow Induk. This was an analytical study with a cross sectional design. There were 90 samples that met the inclusion and exclusion criteria. Data were collected by using anthropometric measurements and questionnaires and then were analyzed by using Spearman's rho test. The results showed that there was 5.6% samples with nutritional status (BMI/A) very thin, 6.7% underweight, normal 68.9%, obese 18.9%. The nutritional status (H/A) of the samples was 38.9% very short, short 12.2 %, 45.6% normal, and tall 3.3%. There was no relationship of nutritional status of children (BMI/A) with mothers’ knowledge about nutrition with ƿ = 0.480 (p <α = 0.05) as well as there was no relationship of nutritional status of children (H/A) with knowledge of maternal nutrition in children aged 1-3 years with ƿ = 0.113 (p <α = 0.05). Conclusion: There was no relationship between nutritional status (BMI/A) as well as (H/A) of children aged 1-3 years with mothers’ knowledge about nutrition in Mopusi village, Lolayan Bolaang Mongondow Induk. Keywords: Nutritional Status, Mother’s Nutritional KnowledgeAbstrak: Penelitian ini bertujuan untuk mengetahui hubungan antara pengetahuan ibu tentang gizi dengan status gizi anak umur 1-3 tahun di Desa Mopusi Kecamatan Lolayan Kabupaten Bolaang Mongondow Induk. Rancangan penelitian ini bersifat analitik dengan menggunakan pendekatan potong lintang. Sampel merupakan bagian dari populasi yang memenuhi kriteria inklusi dan eksklusi berjumlah 90 orang. Data dikumpulkan melalui pengukuran antropometri dan kuesiener pengetahuan dan dianalisis dengan menggunakan uji Spearman’s rho. Hasil penelitian memperlihatkan status gizi (IMT/U) yang sangat kurus 5,6%, kurus 6,7%, normal 68,9%, dan obes 18,9%. Status gizi (TB/U) yang sangat pendek 38,9%, pendek 12,2%, normal 45,6%, dan tinggi 3,3%. Pengetahuan ibu tentang gizi dengan kategori baik sebanyak 12,2%, cukup 42,2 %, dan kurang 45,5%. Analisis statistik menunjukkan tidak terdapat hubungan status gizi (IMT/U) dan pengetahuan gizi ibu dengan anak umur 1-3 tahun, nilai ƿ = 0,480 (p<α=0,05), dan tidak terdapat hubungan status gizi (TB/U) dan pengetahuan gizi ibu pada anak umur 1-3 tahun, nilai ƿ = 0,113 (p<α=0,05). Simpulan: Tidak terdapat hubungan antara status gizi (IMT/U) dan (TB/U) dengan pengetahuan gizi ibu dengan anak umur 1-3 tahun di Desa Mopusi Kecamatan Lolayan Kabupaten Bolaang Mongondow Induk.Kata kunci: status gizi, pengetahuan gizi ibu

Neonatal and fetal therapy of congenital diaphragmatic hernia-related pulmonary hypertension

2021 ◽  
pp. fetalneonatal-2021-322617
Author(s):  
Felix R De Bie ◽  
Catherine M Avitabile ◽  
Luc Joyeux ◽  
Holly L Hedrick ◽  
Francesca M Russo ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Future Research ◽  
Fetal Therapy ◽  
Mortality And Morbidity ◽  
Pulmonary Vasodilation ◽  
Experimental Drug ◽  
Therapeutic Mechanisms ◽  
Experimental Treatments

Congenital diaphragmatic hernia (CDH) is a complex malformation characterised by a triad of pulmonary hypoplasia, pulmonary hypertension (PH) and cardiac ventricular dysfunction. Much of the mortality and morbidity in CDH is largely accounted for by PH, especially when persistent beyond the neonatal period and refractory to available treatment. Gentle ventilation, haemodynamic optimisation and pulmonary vasodilation constitute the foundations of neonatal treatment of CDH-related PH (CDH-PH). Moreover, early prenatal diagnosis, the ability to assess severity and the developmental nature of the condition generate the perfect rationale for fetal therapy. Shortcomings of currently available clinical therapies in combination with increased understanding of CDH pathophysiology have spurred experimental drug trials, exploring new therapeutic mechanisms to tackle CDH-PH. We herein discuss clinically available neonatal and fetal therapies specifically targeting CDH-PH and review the most promising experimental treatments and future research avenues.

Congenital Diaphragmatic Hernia: State of the Art in Translating Experimental Research to the Bedside

2019 ◽  
Vol 29 (04) ◽  
pp. 317-327
Author(s):  
Lina Antounians ◽  
Rebeca Lopes Figueira ◽  
Lourenço Sbragia ◽  
Augusto Zani
Keyword(s):  
Pulmonary Hypertension ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Vascular Remodeling ◽  
Pulmonary Hypoplasia ◽  
Genetic Alterations ◽  
Diaphragmatic Defect ◽  
Morbidity Rate ◽  
Lung Growth ◽  
Mortality And Morbidity

AbstractCongenital diaphragmatic hernia (CDH) is a devastating disease that still carries a high mortality and morbidity rate. Poor outcomes for fetuses and infants with CDH are mainly related to pulmonary hypoplasia (PH) and pulmonary vascular remodeling that leads to pulmonary hypertension (PHTN). Over the last five decades, research efforts have focused on modeling CDH not only to study the pathophysiology of the diaphragmatic defect, pulmonary hypoplasia, and pulmonary hypertension, but also to identify therapies that would promote lung growth and maturation, and correct vascular remodeling. As CDH is a multifactorial condition whose etiology remains unknown, there is not a single model of CDH, rather several ones that replicate different aspects of this disease. While small animals like the mouse and the rat have mainly been used to uncover biological pathways underlying the diaphragmatic defect and poor lung growth, larger animals like the lamb and the rabbit models have been instrumental for pursuing medical and surgical interventions. Overall, the use of animal models has indeed advanced our knowledge on CDH and helped us test innovative therapeutic options. For example, the lamb model of CDH has been the paradigm for testing fetal surgical procedures, including tracheal occlusion, which has been translated to clinical use. In this review, we outline the induction protocols of CDH in animals with the use of chemicals, dietary changes, genetic alterations, and surgical maneuvers, and we describe the studies that have translated experimental results to the bedside.

scholarly journals NeoAPACHE II. Relationship Between Radiographic Pulmonary Area and Pulmonary Hypertension, Mortality, and Hernia Recurrence in Newborns With CDH

2021 ◽  
Vol 9 ◽  
Author(s):  
Ilaria Amodeo ◽  
Nicola Pesenti ◽  
Genny Raffaeli ◽  
Francesco Macchini ◽  
Valentina Condò ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Congenital Diaphragmatic Hernia ◽  
Diaphragmatic Hernia ◽  
Secondary Analysis ◽  
Recurrence Risk ◽  
Hernia Recurrence ◽  
Systolic Pulmonary Artery Pressure ◽  
Clinical Trial Registration ◽  
Mortality And Morbidity ◽  
Lung Area

Congenital diaphragmatic hernia is a rare disease with high mortality and morbidity due to pulmonary hypoplasia and pulmonary hypertension. The aim of the study is to investigate the relationship between radiographic lung area and systolic pulmonary artery pressure (sPAP) on the first day of life, mortality, and hernia recurrence during the first year of life in infants with a congenital diaphragmatic hernia (CDH). A retrospective data collection was performed on 77 CDH newborns. Echocardiographic sPAP value, deaths, and recurrence cases were recorded. Lung area was calculated by tracing the lung's perimeter, excluding mediastinal structures, and herniated organs, on the preoperative chest X-ray performed within 24 h after birth. Logistic and linear regression analyses were performed. Deceased infants showed lower areas and higher sPAP values. One square centimeter of rising in the total, ipsilateral, and contralateral area was associated with a 22, 43, and 24% reduction in mortality risk. sPAP values showed a decreasing trend after birth, with a maximum of 1.84 mmHg reduction per unitary increment in the ipsilateral area at birth. Recurrence patients showed lower areas, with recurrence risk decreasing by 14 and 29% per unit increment of the total and ipsilateral area. In CDH patients, low lung area at birth reflects impaired lung development and defect size, being associated with increased sPAP values, mortality, and recurrence risk.Clinical Trial Registration: The manuscript is an exploratory secondary analysis of the trial registered at ClinicalTrials.gov with identifier NCT04396028.

The relationship of pulmonary artery pressure and survival in congenital diaphragmatic hernia

2004 ◽  
Vol 39 (3) ◽  
pp. 307-312 ◽  
Author(s):  
Peter W Dillon ◽  
Robert E Cilley ◽  
David Mauger ◽  
Christopher Zachary ◽  
Andreas Meier
Keyword(s):  
Pulmonary Artery ◽  
Congenital Diaphragmatic Hernia ◽  
Pulmonary Artery Pressure ◽  
Diaphragmatic Hernia ◽  
Artery Pressure ◽  
Relationship Of ◽  
The Relationship

scholarly journals Hubungan status gingiva dengan kebiasaan menyirih pada masyarakat di Kecamatan Manganitu

e-GIGI ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Cheny Hontong ◽  
Christy N. Mintjelungan ◽  
Kustina Zuliari
Keyword(s):  
Oral Health ◽  
Analytical Study ◽  
Gingival Index ◽  
Chi Square ◽  
Cross Sectional ◽  
Purposive Sampling ◽  
Cross Sectional Design ◽  
Chi Square Analysis ◽  
Relationship Of ◽  
The Relationship

Abstract: Oral health is very important for every individual. Gingivitis is an inflammation of the gingiva caused by the interaction of microorganisms in plaques and bad habits inter alia the habit of chewing betel. This study was aimed to determine the relationship of gingival status and chewing habits based on the duration of betel chewing and chewing frequencies per day among Manganitu district community. This was a descriptive-analytical study with a cross-sectional design. Samples were taken by using purposive sampling. There were 39 respondents as samples. Clinical data of the gingival status was measured by using gingival index (GI) of Loe and Sillnes. The results of chi-square analysis showed a significant correlation between the gingival status and the betel chewing habit based on the duration of betel chewing habit (p = 0.000) and the frequency of betel chewing per day (p = 0.001). Conclusion: Gingival status of Manganitu district community who had betel chewing habit was classified in the severe category.Keywords: Status gingiva, chewing habits, Manganitu districts. Abstrak: Kesehatan gigi dan mulut sangat penting bagi setiap individu. Gingivitis merupakan inflamasi pada gingiva yang disebabkan oleh interaksi mikroorganisme pada plak dan kebiasaan buruk, salah satunya ialah kebiasaan menyirih. Penelitian ini bertujuan untuk mengetahui hubungan status gingiva dengan kebiasaan menyirih berdasarkan lama menyirih dan frekuensi menyirih perhari pada masyarakat kecamatan Manganitu. Jenis penelitian ialah deskriptif-analitik dengan desain potong lintang. Sampel diperoleh dengan metode purposive sampling sebanyak 39 responden. Data klinis tentang status gingiva diukur menggunakan gingival index (GI) menurut Loe dan Sillnes. Berdasarkan hasil uji analisis chi-square terdapat hubungan bermakna antara status gingiva dengan kebiasaan menyirih berdasarkan lama menyirih (p=0,000) dan frekuensi menyirih (p=0,001). Simpulan: Status gingiva masyarakat kecamatan Manganitu yang memiliki kebiasaan menyirih tergolong dalam kategori berat. Kata kunci: status gingiva, kebiasaan menyirih

STRATEGI KOPING ORANG TUA TERHADAP ANAK AUTIS DAN POLA ASUH ORANG TUA

2018 ◽  
Vol 11 (2) ◽  
pp. 196-204
Author(s):  
Asirotul Ma’rifah ◽  
Naning Puji Suryantini Suryantini ◽  
Rina Mardiyana
Keyword(s):  
Coping Strategies ◽  
Sampling Technique ◽  
Children With Autism ◽  
Adaptive Coping ◽  
Autistic Children ◽  
Cross Sectional ◽  
Authoritarian Parenting ◽  
Cross Tabulation ◽  
Relationship Of ◽  
The Relationship

Autism is still a nightmare for most parents. Parents with autism can be very stressful when dealing with a hyperactive child's behavior, aggressive and passive. Stress experienced by parents of children with autism will affect the ability of parents in the parenting role, especially in relation to coping strategies have in dealing with problems of children. The participation of parents is crucial the success of socializing with children with autism in the general population. This study aims to determine the relationship of coping strategies parents of autistic children and parenting parents. This type of research is an analytic correlation with cross sectional approach. The population in this study were all parents of autistic children in SLB Muhammadiyah Mojokerto numbering 15 people. Samples in this study were all parents of autistic children in SLB Muhammadiyah Mojokerto which totaled 15 people by using total sampling technique. Collecting data using questionnaires. Data analized use cross tabulation, presented in a frequency distribution. On cross-tabulation obtained results tend to use maladaptive coping strategies permissive parenting that is 8 (53.3%), there are also respondents who use adaptive coping strategies using authoritarian parenting as much as one person (16.7%), and adaptive coping strategies tend using democratic parenting style as much as 5 people (33.3%). Expected parents still seeking information to broaden their parents on coping strategies of parents of autistic children and parenting parents as well as parents to give special attention for children with autism to the development and advancement of their lives because they have the same rights as any other normal child.

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