scholarly journals Correlation between Serum Uric Acid with Type 2 Diabetes Mellitus and its Complications

2021 ◽  
pp. 335-345
Author(s):  
Jayshri Sadashiv Jankar ◽  
Kumud Namdeorao Harley ◽  
Roshan Kumar Jha
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Diabetes Type ◽  
Type Ii ◽  
Diabetes Type Ii ◽  
The World

Type 2 diabetes mellitus is becoming more common over the world, making it a major health concern. Many research has been carried a link among both higher uric acid concentrations in the body and a higher incidence of type 2 diabetes mellitus. On a biochemical level, uric acid has been proved to have a negative impact on insulin sensitivity in animals. When nitric oxide, essential for glucose uptake, is suppressed, this occurs. The goal of this study is to review past research on the relationship between serum uric acid and diabetes type II in various parts of the world, as well as the prevalence of such a link. Articles were chosen using the PubMed database and EBSCO Information Services. We used all relevant publications to our review that dealt with the connection among both serum uric acid and diabetes type II, in addition to the other articles. Other publications that were not linked to this field were excluded. In this systematic review, serum uric Acid levels were found to be correlated to type 2 diabetes mellitus, metabolic syndrome and carotid artery disease. Atherosclerosis is more common in people with type 2 diabetes. The reliability of concentrations of uric acid levels in blood in predicting type 2 diabetes and enhancing prevention should be the focus of future study.

scholarly journals Relation between serum uric acid and diabetes type II

2018 ◽  
Vol 5 (9) ◽  
pp. 3720 ◽  
Author(s):  
Ghadeer Banjar ◽  
Hanadi Abdulrahim ◽  
Jawaher Alomari ◽  
Reem Aldeijy ◽  
Azzam Almalki ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Diabetes Mellitus Type 2 ◽  
Diabetes Type ◽  
Diabetes Mellitus Type ◽  
Type Ii ◽  
Diabetes Type Ii ◽  
Pubmed Database

Incidence of diabetes mellitus type 2 has been increasing worldwide, making the disease of extreme importance. Several reports have suggested a possible association between serum levels of uric acid (SUA) and higher incidence of diabetes mellitus type 2. On a biological basis, uric acid can negatively affect insulin resistance in animals. This occurs due to the inhibition of nitric oxide which is crucial to achieve glucose uptake. In this study, we aim to: report on previous literature on relation between serum uric acid and diabetes type II in Saudi and prevalence of association between them. PubMed database and EBSCO Information Services were used for articles selection. All relevant articles to our review with the topics regarding the relation between serum uric acid and diabetes type II, and other articles have been used. We excluded other articles, which are not related to this field. The data will be extracted according to specific form in which it is going to be reviewed by the group members. In this meta-analysis we found that SUA levels positively correlate with diabetes mellitus type 2. Future studies should try to determine the reliability of using SUA levels to predict diabetes mellitus type 2 and improve prevention.

Rheumatoid Factor in Type 2 Male Diabetes Mellitus Patients in a Tertiary Care Hospital of Bangladesh

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Rheumatoid Factor ◽  
Serum Uric Acid ◽  
Control Group ◽  
Healthy Male ◽  
Male Patients

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62

scholarly journals Serum uric acid level is associated with type 2 diabetes mellitus and diabetic regulation

2018 ◽  
Vol 1 (4) ◽  
pp. 134-138 ◽  
Author(s):  
Burcin Meryem Atak ◽  
Tuba Taslamacioglu Duman ◽  
Mehmet Zahid Kocak ◽  
Haluk Savli
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level

scholarly journals ANGKA BANDING KADAR ASAM URAT AIR KEMIH TERHADAP SERUM DI DIABETES MELITUS TIPE 2 (Ratio of Urinary Uric Acid Levels and Serum Uric Acid in Type 2 Diabetes Mellitus)

2018 ◽  
Vol 21 (1) ◽  
pp. 28
Author(s):  
Amarensi Milka Betaubun ◽  
Fitriani Mangarengi ◽  
Ruland DN Pakasi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Blood Glucose ◽  
Serum Uric Acid ◽  
Colorimetric Method ◽  
Urinary Levels ◽  
Urine Serum

Diabetes Mellitus (DM) belongs to the group of metabolic diseases. The long-term complications of diabetes such as: diabeticretinopathy, neuropathy, and nephropathy, can be prevented or reduced by controlling the blood glucose levels. Impaired glucose tolerance,hypertension and dyslipidemia can decrease the disappearance from proximal tubules resulting in an increase in serum uric acid. The aimof the study to know the ratio of uric acid urine/serum in DMT2 with controls. This research study used a cross sectional study was andconducted on 35 samples of type 2 diabetes mellitus and 35 control samples of In- and Out-patient Clinics at the Dr. Wahidin SudirohusodoHospital, Makassar. The blood glucose, uric acid levels and urine uric acid were examined by ABX Pentra 400 (colorimetric method). Thenumber of DMT2 male patients was higher than females. Most of their age were between 50−54 years. The ratio of the urinary levels ofurine/serum UA was positively correlated to: age, sex, urine UA in DMT2 and control. Their data were analyzed with unpaired t test (p =0.00). This research showed that the ratio of urine/serum UA in DMT2 was 1.5 times than the controls. The results of this study showedan increase in the ratio of urinary levels of serum uric acid as 1.5 times higher than the controls.

scholarly journals A STUDY OF SERUM URIC ACID LEVELS IN TYPE 2 DIABETES MELLITUS CASES AND ITS COMPARISON WITH THE SERUM CREATININE LEVELS

2021 ◽  
pp. 20-22
Author(s):  
Shajahan Shajahan ◽  
Koneru Sri Lahari ◽  
P. Kiranmai
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
P Value

BACKGROUND:Type 2 Diabetes Mellitus is a major non-communicable disease resulting from insulin resistance and is associated with cardiovascular,neurological and renal complications.Recent studies show association of hyperuricemia and Diabetes Mellitus.Uric acid increases oxidative stress that leads to vascular dysfunction and high intra glomerular pressure leading to renal complications.High serum creatinine is an indicator of renal compromise. OBJECTIVES: To evaluate serum uric acid and serum creatinine levels in type 2 diabetes mellitus patients and to find association between them. METHODOLOGY: The study was conducted in Osmania general hospital. Fifty cases of established Type 2 Diabetes Mellitus formed the study group and 50 normal healthy individuals formed the control group. Serum uric acid, Fasting Blood Glucose (FBS) and serum creatinine were estimated by colorimetric enzymatic methods on Beckman coulter AU5800.Mean values were compared in cases and controls using student t- test.Study group was further studied under 2 subgroups with serum Uric acid < 7 mg/dl and ≥7 mg/dl.In these 2 subgroups the association of Serum uric acid with FBS and creatinine was analysed statistically. RESULTS: Serum uric acid were found high in cases(7.63+/- 3.36)as compared to controls(4.48+/- 1.09) p value < 0.001.Serum creatinine were also high in cases(1.59+/- 1.39 )as compared to controls ( 0.87+/- 0.29) p value <0.005.Study subgroup with serum uric acid ≥7 mg/dl was associated with high creatinine and high fasting blood sugar levels when compared to subgroup with serum uric acid <7 mg/dl. CONCLUSION: Our study showed increased serum uric acid and serum creatinine levels in cases when compared to controls.There was significant association between high serum uric acid and high creatinine levels in cases.Therefore,it is important to measure serum uric acid and serum creatinine levels in diabetics for early detection of renal pathology.

scholarly journals Elevated serum uric acid and triglycerides level in the patients with Type II Diabetes Mellitus- a Nepalese case control study

2017 ◽  
Vol 2 (2) ◽  
pp. 26-34
Author(s):  
Hridaya Parajuli ◽  
Jyotsna Shakya ◽  
Bashu Dev Pardhe ◽  
Puspa Raj Khanal ◽  
Narayan Prasad Parajuli ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Type Ii Diabetes ◽  
Type Ii Diabetes Mellitus ◽  
Diabetic Patients ◽  
Type Ii ◽  
Significant Difference

Background: Hyperuricemia is associated with type 2 diabetes, which is a metabolic disorder of multiple etiologies resulting from defects in insulin action. The present study wascarried out to look for any association between uric acid and Type II Diabetes Mellitus and also status of triacylglycerol level among those patients.Methods: The blood samples were collected 100 diabetic and 100 non-diabetic individuals in the department of biochemistry and then analyzed for estimation of blood glucose, Uric Acid and Triacylglycerol level.Results: The average level of serum uric acid in diabetic patients was higher (5.706±1.617) in comparison to non diabetic subjects (4.322±0.784) with statistically significant difference (p≤0.05). For female the result indicate there was a positive correlation between (FBS and triglycerides) and (triglycerides and uric acids) which was statistically significant (r =-0.465, n = 41, p = 0.002) and(r =-0.370, n = 41, p = 0.017) respectively.Conclusions: This study documents that hyperuricemia is associated with type 2 diabetes mellitus. Furthermore, the serum triacylglycerol and serum uric acid is also found to be associated risk factors for diabetic complications. Hence, timely diagnosis and management of diabetes is vital to control the complications related to diabetes.Ann. Clin. Chem. Lab. Med. 2016:2(1); 26-34

scholarly journals Comparative Study of Level of Serum Uric Acid in Type 2 Diabetes Mellitus Associated with Hypertension

2018 ◽  
Vol 9 (2) ◽  
pp. 96-101
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Nazneen Sultana ◽  
Md Jamil Hasan Karami ◽  
Ayatunnessa ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Exercise Time ◽  
The Mean ◽  
And Control

Background: The role of uric acid in the progression of prediabetes to diabetes has been known. Serum uric acid has been shown to beassociated with cardiovascular disease, hypertension, and chronic kidney disease. However, conflicting data exist asregards the serum uric acid (UA) levels in type 2 diabetes mellitus, which are associated with risk factors andcomplications.Material & Methods: The present study was designed to look for any association of serum uric acid with hypertension in type 2diabetes mellitus, taking into consideration the relevant clinical, biochemical and the anthropometric data. 110 patientswith type 2 male diabetes mellitus as case and 100 healthy malecontrols were included in this study.Results: This study shows that there were significant differences in mean of age, duration of DM, exercise time, waist hip ratio, systolic blood pressure and diastolic blood pressure within case and control but no significant differences of mean BMI was found between and control. The mean age, duration of DM, exercise time, waist hip ratio, systolic blood pressure and diastolic blood pressure and BMI were (51.83±9.911 years, 6.87±5.54 years, 1.94±.831 hours, .92±.03, 140±6.75 mm of Hg,90±2.41 mm of Hg and 25.43±3.19 Kg/m2 respectively), where as in controls these were (44.81±9.66 yrs, 00 years, 1.12±.327 hours, .91±.03, 130±1.28 mm of Hg, 80±6.18 mm of Hg and 24.96±3.02 Kg/m2 respectively). This table also shows that significant differences in mean of FBS, ABF, HbA1C and S. Uric acid between case and control, but there was no significant differences of mean TG, Cholesterol, HDL and LDL. The mean of FBS, ABF, HbA1C and S. Uric acid among the cases were (8.19±2.48 mmol/L, 11.29±3.47 mmol/L, 7.96±6.04 mg%, 189.72±111.36 mg/dl, 179±43 mg/dl, 38.38±13.77 mg/dl, 102.10±35.79 mg/dl and 8.39±2.61 mg/dl respectively, on the other hand among the control these were 5.91±1.13 mmol/L, 9.19±1.95 mmol/L, 5.93±1.01 mg%, 200±104.49 mg/dl, 183±42.25 mg/dl, 38.14±5.52 mg/dl, 110±33.23 mg/dl and 5.14±.84 mg/dl respectively.Anwer Khan Modern Medical College Journal Vol. 9, No. 2: Jul 2018, P 96-101

scholarly journals STUDY OF SERUM URIC ACID LEVEL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

2021 ◽  
pp. 36-38
Author(s):  
Rohit Mathew ◽  
Aswathy Joseph
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Life Style Changes

BACKGROUND:Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. AIM:To evaluate the serum uric acid level in patients with type 2 Diabetes mellitus. MATERIALS AND METHODS:It was a prospective observational study conducted on 100 patients attending Medicine Department of Jhalawar Medical College, Jhalawar, Rajasthan. The study was done to assess the uric acid status in patients with diabetes mellitus and to find out its association with Age, Gender, Body Mass Index (BMI), Waist Hip Ratio (WHR), Dyslipidemia and Hypertension. Relevant history, vitals, clinical examination and laboratory investigations were done and recorded. RESULTS:This study evaluated the level of serum uric acid in Type 2 diabetes mellitus patients and confirmed there significantly high prevalence of hyperuricemia among type 2 diabetes subjects and increased association with increasing age, BMI, WHR, Dyslipidemia, Hypertension and female sex. CONCLUSION: Patients with Poor metabolic control and longer duration of diabetes were more susceptible to develop various complications including hyperuricemia. Early diagnosis and control of Diabetes Mellitus and its complications is indicated and potential therapeutic approaches (therapeutic life style changes and pharmacotherapy) should be initiated.

scholarly journals Serum uric acid levels in type 2 diabetes mellitus among South Indian Urban Population: A cross sectional study

2020 ◽  
Vol 9 (6) ◽  
pp. 20-24
Author(s):  
Harish Rangareddy ◽  
Venkateshappa C
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Waist Hip Ratio

Background and aim: Hyperuricemia is common in individuals with obesity, metabolic syndrome and type 2 diabetes mellitus. This has been attributed to the hyperinsulinemia due to insulin resistance in T2DM and it’s effect on the renal excretion of uric acid. There have been recent studies depicting that hyperuricemia may independently predict the development of diabetes. However, there are conflicting studies of hypouricemia in T2DM as well which may be due to increased glomerular filtration rate with increased renal clearance of uric acid. In order to add further evidence to the existing database of knowledge about uric acid metabolism in T2DM this study was carried out. Material and Methods: This cross sectional study and the subjects were selected according to inclusion and exclusion criteria. Data recorded included serum uric acid, HbA1c, fasting and post prandial plasma glucose, serum creatinine, fasting lipid profile and waist hip ratio. Results: The mean value of serum uric acid was 5.11±1.2 mg/dL in diabetics and 4.59±1.12 mg/dL in non-diabetics, though within the normal reference range was statistically significant (p=0.029). However, the association of hyperuricemia (serum uric acid >7mg/dL) as a risk factor for diabetes mellitus was not significant (p=1.000). Waist circumference in cases was 94.8 ± 10 cm and in controls it was 86.6 ± 11.6 cm (p<0.001). Waist-hip ratio in diabetics was 1.0 ± 0.11 and in non-diabetics 0.9 ± 0.08 (p<0.001). HbA1c, FBS, PPBS, serum creatinine, waist circumference, waist-hip ratio were significantly increased and HDLc was decreased significantly in diabetes mellitus. Conclusion: Increased serum uric acid, decreased HDLc and increased waist-hip ratio are observed in type 2 diabetes mellitus. Steps should be taken to monitor serum uric acid, lipid profile and anthropometric measurements of diabetics and non-diabetics. Keywords: Uric acid, type 2 Diabetes mellitus

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