scholarly journals Effects of Ocimum sanctum Gestational Administration on Physiological and Behavioral Aspects of Mice Offspring

2021 ◽  
pp. 256-267
Author(s):  
Indu Thakur ◽  
Papiya Bigoniya ◽  
P. Uma Devi
Keyword(s):  
Aqueous Extract ◽  
Social Stress ◽  
Field Performance ◽  
Ocimum Sanctum ◽  
Leaf Aqueous Extract ◽  
Behavioral Aspects ◽  
Eye Opening ◽  
Related Stress ◽  
Memory Enhancer

Aims: Prenatal maternal stress and anxiety affect the offspring causing low birth weight, decreased motor activity, and developmental delays. Ocimum sanctum is cherished as the holiest herb in India and possesses strong adaptogenic, memory enhancer, and anti-stress properties. This study aimed to assess the effect of O. sanctum leaf aqueous extract on preventing pregnancy related stress impact on the mice offspring. Methodology: Pregnant female mice were treated with O. sanctum leaf aqueous extract throughout the gestation period at 100 mg/kg, p.o, while exposed to resident–intruder social stress paradigm. Physiological, morphological, and behavioral aspects of offspring were observed for 6 weeks. Results: Pups of O. sanctum treated mothers showed significantly (P < 0.05) improved body weight, body length, and head length. O. sanctum treatment has significantly reduced eye opening and pinna detachment period (P < 0.05-0.01), and duration for gaining surface righting and mid-air righting refluxes (P < 0.05). O. Sanctum has significantly increased (P < 0.05-0.01) number of correct entries in radial arm maze and line crossing in open field performance. Conclusion: The study outcome proves the beneficial role of O. Sanctum in ameliorating prenatal stress and anxiety induced deleterious effect on offspring.

Green Synthesis of Silver Nanoparticles Using Olden-landia corymbosa and Ocimum sanctum Leaf Aqueous Extract

2020 ◽  
Vol 13 (3) ◽  
pp. 4959-4964
Author(s):  
Prof.(Dr.) Sirshendu Chatterjee Chatterjee ◽  
Shaktijit Das ◽  
Moumita Saha ◽  
Pranabesh Ghosh ◽  
Titav Sengupta ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Green Synthesis ◽  
Aqueous Extract ◽  
Nano Particles ◽  
Bioactive Molecules ◽  
Primary Amines ◽  
Ocimum Sanctum ◽  
Leaf Aqueous Extract ◽  
Vis Spectroscopy ◽  
Ft Ir

The field of nanotechnology is the most renowned area of research in modern day science. One of the most convenient and comprehensive technique related to the synthesis of nanoparticles using plant extracts and their subsequent action. On the other hand, herbal medicines become an integral part of modern-day treatment strategy around the globe; combination of these two ways are widely accepted and beneficial due to its low cost, better societal recognition and less side effects. Phytochemical analysis revealed that leaf aqueous extract of two medicinal plants Oldenlandia corymbosa and Ocimum sanctum, harbours high concentration of antioxidants and bioactive molecules. Hence our present course of study aims at the green synthesis of silver nano-conjugates using Oldenlandia corymbosa and Ocimum sanctum leaf aqueous extracts. The synthesized nano-conjugates have undergone advanced chara-cterization techniques including UV-Vis Spectro-photometry, DLS, and FT-IR. The UV-Vis spectroscopy results showed single peak at 420 nm and 430 nm for Oldenlandia corymbosa and Ocimum sanctum nano-conjugates, respectively. The particle size for Oldenlandia corymbosa and Ocimum sanctum nano-particles are 21.04 nm and 24.36 nm, respectively as observed from the DLS data, and finally, the FT-IR data confirms the conjugation of bioactive molecules of the medicinal plants indicating that primary amines, secondary amines, alcohols, phenols, aldehydes, aliphatic amines, alkenes, functional groups of the bioactive molecules are responsible for the stability of prepared silver nano-conjugates

The Plausible role of Indian Traditional Medicine in combating Corona Virus (SARS-CoV 2): a mini-review

2020 ◽  
Vol 21 ◽  
Author(s):  
Adithya J ◽  
Bhagyalakshmi Nair ◽  
Aishwarya S ◽  
Lekshmi R. Nath
Keyword(s):  
Specific Treatment ◽  
Ocimum Sanctum ◽  
Drug Candidate ◽  
Asparagus Racemosus ◽  
Traditional System ◽  
Traditional Medicines ◽  
Contagious Nature ◽  
Community Transmission ◽  
Novel Virus

: SARS-CoV 2 is a novel virus strain of Coronavirus, reported in China in late December 2019. Its highly contagious nature in humans has prompted WHO to designate the ongoing pandemic as a Public Health Emergency of International Concern. At this moment, there is no specific treatment and the therapeutic strategies to deal with the infection are only supportive, and prevention aimed at reducing community transmission. A permanent solution for the pandemic, which has brought the world economy to the edge of collapse, is the need of the hour. This situation has brought intense research in traditional systems of medicine. Indian Traditional System, Ayurveda has a clear concept of the cause and treatment of pandemics. Through this review, information on the potential antiviral traditional medicines along with their immunomodulatory pathways is discussed. We have covered the seven most important Indian traditional plants with antiviral properties :Withaniasomnifera (L.) Dunal(family: Solanaceae),Tinosporacordifolia(Thunb.)Miers (family:Menispermaceae),Phyllanthusemblica L.(family:Euphorbiaceae),Asparagus racemosus L.(family:Liliaceae), Glycyrrhizaglabra L.(family:Fabaceae), Ocimum sanctum L.(family:Lamiaceae) and Azadirachta indica A.Juss(family:Meliaceae)in this review. An attempt is also made to bring into limelight the importance of dietary polyphenol, Quercetin which is a potential drug candidate in the making against the SARS-CoV2 virus.

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