scholarly journals A Systematic Review on the Role of Topical Corticosteroids for the Management of Radiation Dermatitis

2021 ◽  
pp. 1-11
Author(s):  
Hyder Osman Mirghani ◽  
Abdulmajeed Faisal Albalawi ◽  
Nawal Mohammed Alanazi ◽  
Dina Nasser Abusabir ◽  
Abrar Marwan Alamrani ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Sample Size ◽  
Head And Neck ◽  
Background Radiation ◽  
Radiation Dermatitis ◽  
Cochrane Library ◽  
Topical Steroids ◽  
Cervix Carcinoma ◽  
Topical Corticosteroids

Background: Radiation dermatitis (RD) is a widespread complication of radiation therapy; however, there is still no agreement on the best treatment. The goal of this review is to go over how corticosteroids work throughout the treatment of radiation dermatitis. Methodology: A comprehensive evaluation of randomized controlled trials, retrospective and prospective studies involving topical corticosteroid (TC) for the treatment of radiation dermatitis. A thorough search was carried out in Medline, Embase, the Cochrane library, Clinical trials.gov, and Google scholar. The original search took place in August and was updated on September 2021. There were no restrictions on terminology or dates. Two reviewers independently examined each of the listed papers. A search of the relevant studies of all of the mentioned publications yielded additional papers. Results: We identified 19 studies on the role of corticosteroids for the prevention of radiation therapy. All the papers were published between 2001 and 2021. The total sample size of the included studies was 1974 with a mean sample size of 103.89. Among the included studies, four studies (21.05 %) represented head and neck cancer, 14 studies (73.68 %) were regarding breast cancer and 1 (5.26 %) hospital-based cross-sectional study represented multiple malignancies such as head and neck, breast and cervix carcinoma, respectively. Among all the participants, 1696 (85.91 %) were females while 278 (14.08 %) were males. Conclusion: Prophylactic treatment with TC was found to minimize the rate of RD and wet desquamation. Participants who used topical steroids reported improved symptoms and a higher quality of life, whereas the use of topical steroids during radiation had few side effects. ARD can be prevented using topical corticosteroids, based on these findings. As a result, further research must be done on the most effective TC to utilize during radiation.

Management of severe bio-radiation dermatitis induced by radiotherapy and cetuximab in patients with head and neck cancer: emphasizing the role of calcium alginate dressings

2018 ◽  
Vol 27 (8) ◽  
pp. 2957-2967 ◽  
Author(s):  
Pierluigi Bonomo ◽  
Isacco Desideri ◽  
Mauro Loi ◽  
Lucia Pia Ciccone ◽  
Monica Lo Russo ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Calcium Alginate ◽  
Radiation Dermatitis

Role of Steroids in Preventing Osteoradionecrosis of the Head and Neck: A Systematic Review

2019 ◽  
Vol 128 (5) ◽  
pp. 441-446 ◽  
Author(s):  
Blake S. Raggio ◽  
Ryan D. Winters
Keyword(s):  
Systematic Review ◽  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Confidence Interval ◽  
Head And Neck ◽  
Neck Cancer ◽  
Age Groups ◽  
Data Sources ◽  
Statistical Heterogeneity

Objective: The aim of this study was to summarize the effectiveness of steroids in the prevention of osteoradionecrosis of the head and neck. Data Sources: PubMED, MEDLINE, Embase, Google Scholar, and Cochrane trial registries. Methods: A systematic review of these data sources was performed through September 2018 using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Included were English-language studies evaluating patients of all age groups diagnosed with head and neck cancer who underwent radiation therapy while receiving peritreatment steroids compared with those who did not receive steroids. Results: Two retrospective cohort studies were identified for qualitative review. On the basis of analysis of 25 328 participants (36-82 years of age) with head and neck cancer who underwent radiation therapy, the use of peritreatment steroids was associated with a significantly lower risk for osteoradionecrosis in both studies, with a hazard ratio of 0.74 (95% confidence interval, 0.59-0.94; P = .012) and a relative risk of 0.04 (95% confidence interval, 0.003-0.560; P = .017). Meta-analysis was precluded by clinical and statistical heterogeneity. Overall, the studies were of limited quality with high risk for bias and poor methodology. Conclusions: Limited retrospective data suggest that steroids are predictive of a reduced risk for osteoradionecrosis; however, no definitive conclusions can be made given the poor quality of the available literature. Well-designed, comparison-controlled trials are needed to clarify the promising role of steroids in the prevention of osteoradionecrosis of the head and neck.

scholarly journals A Critical Review of Multimodal Interventions for Cachexia

2020 ◽  
Author(s):  
Clare McKeaveney ◽  
Peter Maxwell ◽  
Helen Noble ◽  
Joanne Reid
Keyword(s):  
Body Composition ◽  
Sample Size ◽  
Small Sample ◽  
Cochrane Library ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Treatment Groups ◽  
Small Sample Sizes

ABSTRACT Currently, there are no standardized treatments for cachexia or severe wasting. There is a growing consensus advocating multimodal interventions to address the complex pathogenesis and metabolic alterations in these conditions. This review examined multimodal treatments intended to alleviate and/or stabilize cachexia and severe wasting. The objectives of this review were to 1) identify multimodal interventions for the treatment of cachexia or associated wasting syndromes in patients with a chronic illness, 2) assess the quality of these studies, and 3) assess the effectiveness of multimodal interventions. Electronic databases including PubMed, MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Library, CINAHL, PEDro, OpenGrey, and clinicaltrials.org were systematically searched using both text words and MeSH (medical subject heading) terms. The literature revealed a dearth of large, well-conducted trials in this area. Fourteen trials (n = 5 cancer, n = 5 chronic obstructive pulmonary disease, n = 4 chronic kidney disease) were included in this review. A total of 1026 patients were included across all studies; sample size ranged between 21 and 138 patients. Baseline and follow-up data were collected between 6 wk and 24 mo. All demonstrated some improvement in favor of the treatment groups, in relevant measures of body composition, nutrition, biomarkers, and functionality; however, caution should be applied due to the heterogenous nature of the interventions and small sample sizes. Overall, the evidence from this review supports the role of multimodal interventions in the treatment of severe wasting. However, randomized controlled trials with a powered sample size and sufficiently lengthy interaction period are necessary to assess if multimodal interventions are effective forms of therapy for improving body composition and nutritional and physical status in patients with cachexia and wasting. The protocol for this review is registered with Prospero (ID: CRD42019124374).

Sign in / Sign up

Export Citation Format

Share Document