A Clinicopathological Study of Malignant Tumors of the Uterine Corpus in a Tertiary Care Center

Aim: To study the clinicopathological spectrum of malignant tumors of the uterine corpus in a tertiary care center and classify it according to the latest WHO classification. Methods: A 2 year study was conducted on 22 diagnosed cases of malignant tumors of uterine corpus. Retrospectively clinical and histopathological details were collected and analyzed. Results: In our study majority (40.90%, 9 of 22) cases belong to the age group of 51-60 years. Abnormal uterine bleeding was the most common clinical presentation. A large share (81.81%) of the tumours was of epithelial origin, followed by mixed and mesenchymal tumors. Nearly 94% of the epithelial tumours were Endometrioid Adenocarcinomas. Majority of the cases were at pT1a stage (42.1%) at the time of diagnosis, followed by pT1b stage (31.57%). Very few cases (21%) presented with nodal metastasis. All the cases with nodal metastasis showed Lymphovascular invasion in the tumor proper and were usually high grade tumors. Conclusion: The prognosis of the patients with malignant tumors of uterine corpus depends on stage, grade, myometrial invasion, tumor size, lymphovascular invasion etc. Clinical findings in these tumors are not specific, so Histopathological examination plays a vital role in diagnosing and assessing the prognosis of these tumors. Classifying these tumors according to the recently proposed molecular classification will aid in patient specific targeted therapy.

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Depth of Invasion as a Predictor of Cervical Nodal Metastasis of Oral Tongue Squamous Cell Carcinoma: Findings From a Tertiary Care Center in Pakistan

Cureus ◽

10.7759/cureus.18976 ◽

2021 ◽

Author(s):

Adnan Y Muhammad ◽

Rahim Dhanani ◽

Summaiya Salman ◽

Zeeshan Shaikh ◽

Shayan K Ghaloo ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Care Center ◽

Tertiary Care ◽

Nodal Metastasis ◽

Tongue Squamous Cell Carcinoma ◽

Depth Of Invasion ◽

Tertiary Care Center ◽

Oral Tongue

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Pigmented Lesions of Skin: A Histopathologic Experience at a Tertiary Care Center in Central Nepal

Journal of College of Medical Sciences-Nepal ◽

10.3126/jcmsn.v17i1.28276 ◽

2021 ◽

Vol 17 (1) ◽

pp. 1-9

Author(s):

Binita Goyal ◽

Suman Rai ◽

Mamata Sedhain ◽

Pratigya Subedi

Keyword(s):

Cell Carcinoma ◽

Malignant Tumors ◽

Histopathological Examination ◽

Care Center ◽

Tertiary Care ◽

Skin Lesions ◽

Histopathological Diagnosis ◽

Female Ratio ◽

Pigmented Lesions ◽

Pigmented Skin Lesions

Introduction Pigmented skin lesions refer to lesions that are brown, black or blue in color. These are not always melanocytic in origin. Keratinocytic, vascular or reactive pigmentation in other lesions can also appear pigmented. The main aim of the study was to see the histopathological spectrum and objective was to compare clinical and histopathological diagnoses in pigmented skin lesions. Methods This descriptive study was carried out on 43 pigmented skin lesions that were biopsied over a 1 and half year period from Jan 2018 to June 2019 in College of Medical Sciences and Teaching Hospital. Results Age of the patient ranged from 10 to 88 years and mean±SD was 42.02±19.73 years. There were 21 (48.8%) males and 22 (51.2%) females with a male female ratio 0.9:1. Melanocytic nevus was the most common histopathological diagnosis (11 cases, 25.6%). Reactive pigmentation was seen in 20 (46.5%) cases. Malignant cases comprised 6 (14.0%) cases which included 2 (4.7%) cases of melanoma, 2 (4.7%) cases of pigmented basal cell carcinoma and 1 (2.3%) case each of basaloid squamous cell carcinoma and trichoblastic carcinoma each. Clinicopathological agreement could be seen in 32 (74.4%) cases. However, malignancy was clinically suspected in only half of histologically diagnosed cases. Conclusions Melanocytic nevi were the most common pigmented lesions diagnosed. Not all pigmented lesions are melanocytic in origin. Malignant tumors can sometimes appear deceptively benign and also tumors other than melanoma can be pigmented. Hence, histopathological examination remains the gold standard in diagnosing these conditions and guiding appropriate management. Keywords: melanocytic; melanoma; nevus; pigmented.

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Antistreptolysin O Positivity in Chronic Tonsillitis: Rare or Common?

Otorhinolaryngology Clinics - An International Journal ◽

10.5005/aijoc-7-1-1 ◽

2015 ◽

Vol 7 (1) ◽

pp. 1-2

Author(s):

KB Prashanth ◽

Nitha Mary George

Keyword(s):

Early Detection ◽

Histopathological Examination ◽

Care Center ◽

Tertiary Care ◽

Preventive Measure ◽

Chronic Tonsillitis ◽

Tertiary Care Center ◽

Streptococcal Infections ◽

History Taking ◽

Detailed History

ABSTRACT Objective To determine the frequency of antistreptolysin O (ASLO) positivity in cases of proven chronic tonsillitis. Materials and methods The present study was conducted in a tertiary care center from January to October 2013. A total of 150 patients who presented with features suggestive of chronic tonsillitis and willing for surgery were included in the study. On admission, following a detailed history taking and clinical examination, preoperative investigations along with ASLO titers were done. Following medical and anesthetic fitness, the patients underwent tonsillectomy with or without adenoidectomy and the tonsillar specimens were sent for histopathological examination. Results A total of five out of the 150 patients showed ASLO titer positivity (>200 IU/ml) and all were histopathologically proven cases of chronic tonsillitis. Conclusion Early detection and treatment of Streptococcal tonsillar involvement could be a preventive measure against the future predilection of other predisposed organs to more severe and debilitating streptococcal infections.

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