The arts sometimes precede the sciences in the discovery of fundamental visual principles. Victor Vasarely’s “Nested Squares” show an illusory effect in which corners look brighter and more salient than straight edges, despite having equivalent luminance. This chapter summarizes recent research, originally based on Victor Vasarely’s Nested Squares illusion, to discover the related perceptual and underlying physiological principles. The results offer significant insights into how corners, angles, curves, and line endings affect the appearance of brightness, shape, salience, depth, and color in our brains. Concepts covered include the alternating brightness star illusion, center-surround simulations, brain activation, corner perception, and the redundancy-reducing hypothesis.