Cost effectiveness of routine histology for haemorrhoidectomy specimens

Background: Routine histology for haemorrhoidectomy specimens remains commonplace in clinical practice, as a method of detecting incidental anal cancer. However, its utility and cost-effectiveness is unclear in the literature. This study aimed to determine the cost-effectiveness of routine histology for haemorrhoidectomy specimens in a regional Australian hospital. The secondary aim was to determine the proportion of specimens sent for histology, and whether individual surgeons had a statistically significant preference for whether to send for histology.Methods: This was a retrospective cohort study of patients who received haemorrhoidectomies at Hervey Bay Hospital between March 2012 and May 2020. Cost effectiveness of routine histology was investigated by weighing the number of incidental anal cancers detected against the cost of analysis. The proportion sent for histology was determined, both as a whole and by individual consultant surgeons.Results: Routine histology was ordered in 65% of patients who received haemorrhoidectomies over the study period (n=119), costing $13,623 AUD ($1,651 AUD per year). No cases of incidental anal dysplasia or neoplasia were found. Only 1 of the 8 most prolific surgeons over the study period demonstrated a statistically significant preference for whether to send for histology.Conclusions: Our study does not support routine histology for haemorrhoidectomy specimens as a cost-effective practice for detecting incidental anal cancer. Most individual surgeons did not display a clear preference for whether to send for histology.

An efficient numerical simulation and mathematical modeling for the prevention of tuberculosis

The main purpose of this research is to use a fractional-mathematical model including Atangana–Baleanu derivatives to explore the clinical associations and dynamical behavior of the tuberculosis. Herein, we used a lately introduced fractional operator having Mittag-Leffler kernel. The existence and inimitability problems to the relevant model were examined through the fixed-point theory. To verify the significance of the arbitrary fractional-order derivative, numerical outcomes were explored from the biological and mathematical viewpoints using the values of model parameters. The graphical simulations show the comparison of the predictor–corrector method (PCM) and Caputo method (CM) for different fractional orders and the results indicated the significant preference of PCM over CM.

Oviposition Preferences of Oriental Fruit Moth Grapholita Molesta (Lepidoptera: Tortricidae) To Pear HIPVs

Herbivore-induced plant volatiles (HIPVs) are regarded as an indirect plant defense against herbivores, since they attract natural enemies to the infested plant. On the other hand, HIPVs also affect behavioral responses of herbivores. In a previous study, Lytopylus rufipes, a parasitoid of the oriental fruit moth (Grapholita molesta), showed positive responses to pear HIPVs, but the influence of pear HIPVs on G. molesta is still unclear. To better understand these responses, we first tested oviposition preferences of G. molesta to uninfested and infested pear shoots (US and IS, respectively) and uninfested mature leaves (ML) in dual-choice bioassays with a cylindrical tube. Then, preferences to volatile components were also assessed. Results show that G. molesta females preferred US-, IS-, and ML-treated areas compared to the control area (no leaves), respectively. Subsequently, G. molesta females preferred IS over US, and US more than ML when comparing pear tissues. Furthermore, G. molesta females didn’t show any significant preference to individual volatile components, but more eggs were laid in the area treated with a synthetic pear HIPV blend, compared to the hexane-treated area (control). These results indicate that G. molesta females do not avoid infested pear shoots nor HIPVs. Moreover, HIPVs may recruit not only natural enemies, but herbivores to the release point of HIPVs. Thus, it is important to examine the responses of G. molesta females to HIPVs in the field before employing them for pest management.

Conspecific neighbors and kinship influence egg cannibalism in the green lacewing, Chrysoperla carnea (Stephens)

Background Chrysoperla carnea (Stephens) (Neuroptera: Chrysopidae) is an illustrious predator that performs cannibalism upon facing small and defenseless conspecifics. Eating preference of C. carnea larvae was investigated between conspecific and host (Sitotroga cerealella) eggs. Early instars of C. carnea express significant preference toward conspecific eggs over host eggs. Experiments were carried out to examine the role of conspecific neighbors in execution of cannibalistic decision. These cannibalistic behaviors of larvae were also investigated through locomotion bioassays using the video tracking software ANY-maze®. Results Larvae commit low egg cannibalism when alone but express higher cannibalism in the presence of conspecific larvae in the neighborhood. The role of relatedness in egg cannibalism was investigated when larvae were offered a choice between conspecific eggs from related and unrelated parents. Larvae did a discrimination between eggs of their own parents and those of other parents. Conclusion Behavioral bioassays showed attraction toward conspecific eggs and the eggs of unrelated parents. This study emphasizes the significance of informational and descriptive cues that modulate the cannibalistic expression in C. carnea.

Can Lambs in Pain Identify Medicated Feed?

Lambs in Australia undergo painful husbandry procedures as part of common husbandry. The magnitude and duration of pain are difficult to assess in lambs. Most currently used methods rely on behavioral expressions and physiological markers that may fail to detect the state of pain an animal experience. This study examined motivation of 12-week-old lambs experiencing chronic pain to self-medicate by consumption of feed containing an analgesic agent as an indicator of pain in lambs. In this study, 36 male Merino lambs were individually penned and acclimated to pelleted feed and two artificial odors: strawberry and banana. Once acclimated to odored feed, lambs were tested for their individual preference for the odors. Lambs were then assigned to one of two groups: Sham—sham handled day 0 and 7 or Ring—Ring castrated day 0 and tail docked day 7. To enable self-medication testing, lambs underwent a conditioning period (day 0–3) followed by the self-medication period (day 7–12). On day 0 lambs were castrated or sham handled, and then offered only medicated feed that contained an odor cue (either strawberry or banana). On day 7, lambs underwent tail-docking or sham handling and were offered both the conditioned medicated feed and non-medicated feed. Amount of each feed consumed was recorded 1 and 12 h after offer each day. Blood samples were taken for cortisol and white blood cell analysis and behavioral observations were recorded for 12 h following treatment. There was no difference in preference for medicated feed between Ring and Sham lambs during the self-medication phase (P = 0.18). Lambs in both groups displayed a significant preference for strawberry cued medicated feed during the self-medicated period when compared to the other testing periods (P = 0.05). Ring lambs displayed more active pain behaviors (mean = 15.1) than Sham (mean = 0.4, P < 0.05). Following castration, Ring lambs had a higher neutrophil/lymphocyte ratio at 6, 24, 48, and 72 h. This study was not able to demonstrate that lambs can self-medicate for a state of pain.

Do Career Demands and Career Choices Always Coincide? A Matching Perspective Based on Career Anchors and Job Characteristics

Career choice is an important behavior for people wanting to develop their social life and is a key link to doing so. The matching of career choice with an individual’s real work demands will have a significant impact on the development of individuals, organizations, and society. However, at this stage, there are few studies on this matching situation. From the perspective of the matching of career anchors and job characteristics, this study explored the distribution and different characteristics of employees’ career demands and their career choices through a survey of 407 employees, and further discussed the matching status of these. The results of the study are as follows: (1) Individual career demands (career anchors) presented three attributes: single, multiple, and unclear. Among the single career anchor types, life anchors had the largest proportion, while among multiple career anchor individuals, individuals with both challenge anchors and service anchors accounted for the majority. (2) Individual career demands (career anchors) were significantly different across most demographic variables and organizational/work variables. (3) Deviations between employees’ career demands and their career choices seemed to be a common phenomenon, with the highest degree of fit (62.79%) with the entrepreneurial creativity anchor and the lowest degree of fit (21.28%) with the lifestyle anchor. In addition, in an analysis of three job fit characteristics, the entrepreneurial creativity anchor had a significant preference for managerial characteristics, whereas the challenge anchor had a significant preference for technological characteristics. The degrees of fit of the other anchors were characterized by the frequency of ‘right suboptimal fit’ being larger than that of ‘left suboptimal fit’. In other words, a specific career anchor had a significant preference for job characteristics matched by the right career anchor, with the midpoint of the career anchor octagon model defining the angle of observation. This study provides a reference for human resource management departments and for employees’ recognition and planning of career anchors.

Preference for Facial Symmetry Depends on Study Design

Facial symmetry is purportedly attractive, though methods for measuring preference for facial symmetry vary between studies. Some studies have used a two-alternative forced choice (2AFC) task, while others have used a ratings task. How researchers manipulate facial symmetry also varies; some studies have used faces manipulated to be more (or perfectly) symmetrical, while others have used faces manipulated to be more asymmetrical. Here, across three studies, we evaluate and compare these different methods. In Studies 1 and 2 (N = 340 and 256, respectively), we compare facial symmetry preferences as measured by the 2AFC and ratings tasks. Across both studies, we consistently found a significant preference for facial symmetry when using the 2AFC task, but not with the ratings task. Additionally, correlations between facial symmetry preferences as measured by the two tasks were weak or showed no association. In Study 3, 159 participants rated the attractiveness of faces manipulated to be either symmetrical or more asymmetrical. The asymmetrical faces were rated as significantly less attractive compared to the original faces, while the difference in attractiveness ratings between the original and symmetrical versions was comparatively much smaller. These studies suggest that preference for facial symmetry depends greatly on the study design.

Defining Ideal External Female Genital Anatomy Via Crowdsourcing Analysis

Background Despite existing anthropometric data in the literature regarding the variation of female external genital anatomy, the ideal aesthetic characteristics have yet to be defined. Objectives Authors used crowdsourcing in order to better evaluate preferred anatomic characteristics of external female genitalia. Methods Fifty-six total images were digitally created by altering the proportions of the labia minora, labia majora, and clitoral hood. Images with differing ratios were presented in pairs to Amazon Mechanical Turk (Seattle, WA, USA) raters. Three different experiments were performed with each varying two of the three image characteristics to permit two factor modeling. The Bradley-Terry-Luce model was applied to the pairwise comparisons ratings to create a rank order for each image. Preferences for each anatomic variable were compared using chi-squared tests. Results A total of 5000 raters participated. Experiment 1 compared differing widths of the labia majora and labia minora and determined a significant preference for larger labia majora width and mid-range labia minora width (p=0.007). Experiment 2 compared labia minora width versus clitoral hood length and showed a statistically significant preference for wider majoras (p<.001), but no significant preference in clitoral hood length (p=0.54). Experiment 3 compared clitoral hood length versus labia minora width and showed a statistically significant preference for mid-range labia minora widths (p<.001) but no significant preference in clitoral hood length (p=0.78). Conclusions Raters preferred a labia majora to labia minora width ratio of 3:1 with minimal preference in clitoral hood length.

Spontaneous choices for insect-pollinated flower shapes by wild non-eusocial halictid bees

The majority of angiosperms require animal pollination for reproduction and insects are the dominant group of animal pollinators. Bees are considered one of the most important and abundant insect pollinators. Research into bee behaviour and foraging decisions has typically centred on managed eusocial bee species, Apis mellifera and Bombus terrestris. Non-eusocial bees are understudied with respect to foraging strategies and decision-making, such as flower preferences. Understanding whether there are fundamental foraging strategies and preferences which are features of insect groups can provide key insights into the evolution of flower-pollinator co-evolution. In the current study, Lasioglossum (Chilalictus) lanarium and L. (Parasphecodes) sp., two native Australian generalist halictid bees, were tested for flower shape preferences between native insect-pollinated and bird-pollinated flowers. Each bee was presented with achromatic images of either insect-pollinated or bird-pollinated flowers in a circular arena. Both native bee species demonstrated a significant preference for images of insect-pollinated flowers. These preferences are similar to those found in A. mellifera, suggesting that flower shape preference may be a deep-rooted evolutionary occurrence within bees. With growing interest in the sensory capabilities of non-eusocial bees as alternative pollinators, the current study also provides a valuable framework for further behavioural testing of such species.

Enrichment of Oesophageal Speech: Voice Conversion with Duration–Matched Synthetic Speech as Target

Pathological speech such as Oesophageal Speech (OS) is difficult to understand due to the presence of undesired artefacts and lack of normal healthy speech characteristics. Modern speech technologies and machine learning enable us to transform pathological speech to improve intelligibility and quality. We have used a neural network based voice conversion method with the aim of improving the intelligibility and reducing the listening effort (LE) of four OS speakers of varying speaking proficiency. The novelty of this method is the use of synthetic speech matched in duration with the source OS as the target, instead of parallel aligned healthy speech. We evaluated the converted samples from this system using a collection of Automatic Speech Recognition systems (ASR), an objective intelligibility metric (STOI) and a subjective test. ASR evaluation shows that the proposed system had significantly better word recognition accuracy compared to unprocessed OS, and baseline systems which used aligned healthy speech as the target. There was an improvement of at least 15% on STOI scores indicating a higher intelligibility for the proposed system compared to unprocessed OS, and a higher target similarity in the proposed system compared to baseline systems. The subjective test reveals a significant preference for the proposed system compared to unprocessed OS for all OS speakers, except one who was the least proficient OS speaker in the data set.