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Chemosensors ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 17
Author(s):  
Sarizhat D. Tataeva ◽  
Kurban E. Magomedov ◽  
Ruslan Z. Zeynalov ◽  
Naida D. Baygishieva ◽  
Viktorya S. Magomedova ◽  
...  

The technology for manufacturing a film membrane of the metamizole-selective electrode containing ion associate metamizole-octadecylammonium ODAH+MT− as an electrode active component (EAC) has been proposed. The main potentiometric characteristics of the metamizole-selective electrode have been determined. The expediency of the proposed design of the metamizole selective electrode for the determination of metamizole in dosage forms has been substantiated. The best composition of the membrane (wt.%) of the metamizole-selective electrode has corresponded to: ODAH+MT−—5.3; 2-nitrophenyloctylether—63.1; poly(vinyl chloride)—31.6. Electrode-active component in the membrane phase functions as an ion associate ODAH+MT−. Potentiometric characteristics of metamizole-selective electrode have been determined, which corresponded to: linear range 1 × 10−2–1 × 10−4 with limit of detection 4.58 × 10−5 M, electrode function slope −48.5 mV/dec., working interval pH 4.5–7.3, response time 60 s. The potentiometric coefficients of selectivity of the metamizole-selective electrode with respect to various ions have been determined. The possibility of determining metamizole in a medicinal product has been tested. The results of the analyses show good agreement between the two methods (relative error less than 7.0%) with coefficients of variation less than 5% for MT-SE and iodometric methods.


2021 ◽  
Vol 56 (1) ◽  
pp. 61-66
Author(s):  
O. F. Aid ◽  
A. Senoussaoui

We introduce the relevant background information thatwill be used throughout the paper.Following that, we will go over some fundamental concepts from thetheory of a particular class of semiclassical Fourier integraloperators (symbols and phase functions), which will serve as thestarting point for our main goal. Furthermore, these integral operators turn out to be bounded on$S\left(\mathbb{R}^{n}\right)$ the space of rapidly decreasingfunctions (or Schwartz space) and its dual$S^{\prime}\left(\mathbb{R}^{n}\right)$ the space of temperatedistributions. Moreover, we will give a brief introduction about$H^s(\mathbb{R}^n)$ Sobolev space (with $s\in\mathbb{R}$).Results about the composition of semiclassical Fourier integraloperators with its $L^{2}$-adjoint are proved. These allow to obtainresults about the boundedness on the Sobolev spaces$H^s(\mathbb{R}^n)$.


2021 ◽  
Author(s):  
Rosita Kokotanekova ◽  
Colin Snodgrass ◽  
Abbie Donaldson ◽  
Pedro Lacerda ◽  
Cyrielle Opitom
Keyword(s):  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Manuel Kaulich ◽  
Verena M. Link ◽  
John D. Lapek ◽  
Yeon J. Lee ◽  
Christopher K. Glass ◽  
...  

AbstractDuring early G1 phase, Rb is exclusively mono-phosphorylated by cyclin D:Cdk4/6, generating 14 different isoforms with specific binding patterns to E2Fs and other cellular protein targets. While mono-phosphorylated Rb is dispensable for early G1 phase progression, interfering with cyclin D:Cdk4/6 kinase activity prevents G1 phase progression, questioning the role of cyclin D:Cdk4/6 in Rb inactivation. To dissect the molecular functions of cyclin D:Cdk4/6 during cell cycle entry, we generated a single cell reporter for Cdk2 activation, RB inactivation and cell cycle entry by CRISPR/Cas9 tagging endogenous p27 with mCherry. Through single cell tracing of Cdk4i cells, we identified a time-sensitive early G1 phase specific Cdk4/6-dependent phosphorylation gradient that regulates cell cycle entry timing and resides between serum-sensing and cyclin E:Cdk2 activation. To reveal the substrate identity of the Cdk4/6 phosphorylation gradient, we performed whole proteomic and phospho-proteomic mass spectrometry, and identified 147 proteins and 82 phospho-peptides that significantly changed due to Cdk4 inhibition in early G1 phase. In summary, we identified novel (non-Rb) cyclin D:Cdk4/6 substrates that connects early G1 phase functions with cyclin E:Cdk2 activation and Rb inactivation by hyper-phosphorylation.


Author(s):  
Amin Kabir ◽  
Nimmi Sharma ◽  
John E Barnes ◽  
Alicja Urbanczyk ◽  
Justin Fagnoni ◽  
...  

Photonics ◽  
2021 ◽  
Vol 8 (6) ◽  
pp. 224
Author(s):  
Vijayakumar Anand ◽  
Joseph Rosen ◽  
Soon Hock Ng ◽  
Tomas Katkus ◽  
Denver P Linklater ◽  
...  

Image enhancement techniques (such as edge and contrast enhancement) are essential for many imaging applications. In incoherent holography techniques such as Fresnel incoherent correlation holography (FINCH), the light from an object is split into two, each of which is modulated differently from one another by two different quadratic phase functions and coherently interfered to generate the hologram. The hologram can be reconstructed via a numerical backpropagation. The edge enhancement procedure in FINCH requires the modulation of one of the beams by a spiral phase element and, upon reconstruction, edge-enhanced images are obtained. An optical technique for edge enhancement in coded aperture imaging (CAI) techniques that does not involve two-beam interference has not been established yet. In this study, we propose and demonstrate an iterative algorithm that can yield from the experimentally recorded point spread function (PSF), a synthetic PSF that can generate edge-enhanced reconstructions when processed with the object hologram. The edge-enhanced reconstructions are subtracted from the original reconstructions to obtain contrast enhancement. The technique has been demonstrated on FINCH and CAI methods with different spectral conditions.


2021 ◽  
Author(s):  
Yang Yang ◽  
Deepika Jayaprakash ◽  
Robert Hollingworth ◽  
Steven Chen ◽  
Amy Jablonski ◽  
...  

The E3 ligase RNF168 has been suggested to have roles at DNA replication forks in addition to its canonical functions in DNA double-strand break (DSB) signaling. However, the precise role of RNF168 in DNA replication remains unclear. Here we demonstrate that RNF168 is recruited to DNA replication factories independent of the canonical DSB response pathway regulators and identify a degenerate PCNA-Interacting Peptide (DPIP) motif in the C-terminus of RNF168 which mediates its binding to PCNA. An RNF168 mutant harboring substitutions in the DPIP box fails to interact with PCNA and is not recruited to sites of DNA synthesis, yet fully retains its ability to promote DSB-induced 53BP1 foci. Surprisingly, the RNF168 DPIP mutant also retains the ability to support ongoing DNA replication fork movement, demonstrating that PCNA-binding is dispensable for normal S-phase functions. However, replisome-associated RNF168 functions to suppress the DSB-induced 53BP1 DNA damage response during S-phase. Moreover, we show that WT RNF168 can perform PCNA ubiquitylation independently of RAD18 and also synergizes with RAD18 to amplify PCNA ubiquitylation. Taken together, our results identify non-canonical functions of RNF168 at the replication fork and demonstrate new mechanisms of cross talk between the DNA damage and replication stress response pathways.


Fuel ◽  
2021 ◽  
Vol 287 ◽  
pp. 119415
Author(s):  
M. Koch ◽  
L. Pörtner ◽  
Y. Gu ◽  
M. Schiemann ◽  
W. Rohlfs ◽  
...  

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