Background: Coleus forskohlii plant called in KSA (Al-Shar or Aspane Zattar), it discovery nearly at western south area, KSA. It contained flavonoids, alkaloids, tannins, terpenoids, steroids, saponins, and sugars. The essential oil had crucial result against human-pathogenic-bacteria as Bacillus Spp., Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The aim: It was the first time in Ranyah-region, KSA for proving and supporting the ancient Saudi-customs using Coleus forskohlii plant boiled-water-extract to protect person-health from human-bacterial-diseases and to consider as medicinal plant that easy getting, cheep and grows mostly in the southwestern region, KSA. Materials and Methods: Coleus forskohlii plant were collected from Ranyah-region, KSA, to powder obtaining. The identified human-pathogenic-bacteria were obtained via the laboratory from diagnosed infected human cases. The bacterial suspension were added to boiled-water-extract, were followed up the bacterial growth. Results: The average dry cell weight estimation showed Pseudomonas aeruginosa stayed for 50 hour, Klebsiella pneumoniae 45 hour and Escherichia coli 40 hour. Staphylococcous aureus remained alive for 35 hour, Bacillus Spp., 30 hour. The average membrane filter estimation was found Escherichia coli did not give a large number of colonies at 40 hours, Klebsiella pneumoniae stopped producing colonies till 45 hours and Pseudomonas aeruginosa persisted until 50 hour. Conclusions: It was concluded that the Coleus forskohlii plant boiled-water-extract eliminated human-pathogenic-bacteria, as the ancient Saudi-customs were based on its use for the person-health and its adoption as a medicinal plant.