The term ‘differentiate' is often used in the field of education to signify the modification of learning based on student readiness, learning profile, and academic skills, with changes being made to the depth, pace, and breath of the process (instruction), content (curriculum), and product (students' work and assessments). This chapter will focus on differentiation as it relates to gifted culturally different students, with an emphasis on the inclusion of cultural considerations within learning profiles discuss the necessity of both rigor and cultural relevance in lessons, while also being affirmed by what is taught. The curricula and program challenges within general and gifted classrooms will also be discussed. A brief overview of Bloom's taxonomy and James Banks's multicultural curriculum model will be shared in addition to an overview of Ford's Bloom-Banks matrix along with a revised layout of Trotman Scott's color-coded layout of Ford's matrix with pros and cons for each matrix quadrant.