Living longer increases the risk of cognitive decline, which can cause individuals to become dependent on caregivers. Due to the stressful nature of caregiving, caregiver burden often negatively impacts the quality of life of caregivers and can even cause premature death. In the present study, we examined the relationships between caregiver burden and social support, religious coping, religious attendance, and participation in private prayer. We hypothesized that each variable would contribute uniquely to caregiver burden, such that greater caregiver burden would be associated with lower religious attendance, private prayer, religious coping, and social support. Fifty-nine dementia/Alzheimer’s caregivers (72% women) completed surveys. In a multiple linear regression analysis, variables explained 24.4% of the variance in caregiver burden, R2 = .24, Adj. R2 = .14, F(7, 49) = 2.26, p = .04. Further examination revealed that lower family support was related to greater caregiver burden (β = −.28, p = .04), consistent with predictions. Counter to our hypothesis, greater participation in private prayer was related to higher levels of caregiver burden, but only at the trend level (β = .39, p = .06). Our data suggest that social support, particularly from family members, can help caregivers burdened from the stressful nature of caregiving.