Internet Development, Level of Industrial Synergy, and Urban Innovation

Innovation increases total factor productivity and leads to economic development. Based on panel data of 284 prefecture-level cities from 2001 to 2018, the current study uses a dynamic panel data model to empirically test the global and heterogeneous effects of internet development and industrial synergy on the level of urban innovation. Results found that the internet development significantly promoted the urban innovation level, and industrial collaboration was found to have a positive impact on the urban innovation level. Moreover, it was determined that the regulatory effect of the internet promoted industrial collaboration to improve the level of urban innovation. Variations in the impact of internet development and the industrial collaboration level on the urban innovation level were found in cities. Particularly, the impact of internet development and the industrial collaboration level on the urban innovation level in high-level cities was less significant. A positive role of the government is required to improve the level of urban innovation. Particularly, it is required to connect enterprises with universities to exchange scientific and technological knowledge, thereby improving urban innovation.

Long Non-Coding RNA CRNDE is Involved in Resistance to EGFR Tyrosine Kinase Inhibitor in EGFR-Mutant Lung Cancer via eIF4A3/MUC1/EGFR Signaling

Introduction: Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) is an intractable challenge for many clinical oncologists. The mechanisms of resistance to EGFR-TKIs are complex. Long non-coding RNAs (lncRNAs) may play an important role in cancer development and metastasis. However, the biological process between lncRNAs and drug resistance to EGFR-mutated lung cancer remains largely unknown.Methods: Osimertinib- and afatinib-resistant EGFR-mutated lung cancer cells were established using a stepwise method. Microarray analysis of non-coding and coding RNAs was performed using parental and resistant EGFR-mutant non-small cell lung cancer (NSCLC) cells and evaluated by bioinformatics analysis through medical-industrial collaboration.Results: Colorectal neoplasia differentially expressed (CRNDE) and DiGeorge syndrome critical region gene 5 (DGCR5) lncRNAs were highly expressed in EGFR-TKI-resistant cells by microarray analysis. RNA-protein binding analysis by medical-industrial collaboration revealed eukaryotic translation initiation factor 4A3 (eIF4A3) bound overlappingly to CRNDE and DGCR5. The CRNDE downregulates the expression of eIF4A3, mucin 1 (MUC1), and phospho-EGFR. Inhibition of CRNDE activated the eIF4A3/MUC1/EGFR signaling pathway and apoptotic activity, and restored sensitivity to EGFR-TKIs.Conclusions: The results showed that lncRNA CRNDE is associated with the development of resistance to EGFR-TKIs in EGFR-mutant NSCLC cells. CRNDE may be a novel therapeutic target to conquer EGFR-mutant NSCLC.

The Effect of University Context on Academics' Engagement with Industry

Drawing on the theory of planned behavior, this study investigates the impact of academics' perception of university context on their engagement with industry via the mediation of academics' intention to industrial collaborations. The third mission and supportive policy were put forward as two university influence factors. From analysis results of 564 questionnaire responses, we found that academics' perception of university context had significant effect on academic engagement. In addition, the relationship between university mission, supportive policy and academics' industrial engagement were partially mediated by academics' intention to industrial collaboration.