The thin red line between pathological and physiological inflammatory background in the gastric mucosa

NA

PENGGUNAAN DATA MINING DALAM HIT RATE IMPORTASI JALUR MERAH DENGAN MODEL DECISION TREE

ABSTRACT: Customs and Excise faces a big challenge to be able to increase the hit rate of red line imports by 40% in accordance with the Blueprint for the 2014-2025 Ministry of Finance Institutional Transformation Program and international benchmarks. Through a qualitative study, this study aims to determine the use of data mining that is applied to the risk engine based on import data, people's experiences, and research results of customs institutions of other countries. The data mining method used is CRISP-DM, classification method, and decision tree model, using data imported from the red line KPU BC Type A Tanjung Priok for the period September – December 2019 and January 2020. The results show that the use of data mining can increase the hit rate of red line importation. The most relevant attribute in classifying data is the sending country which is categorized as a root node, while the import duty tariff attribute does not provide information on data classification. This research is expected to provide a new perspective for the KPU BC Type A Tanjung Priok in an effort to improve the risk engine targeting and risk engine routing of Customs and Excise. Keywords: CRISP-DM, data mining, decision tree, hit rate, the red line import. ABSTRAK: Bea dan Cukai menghadapi tantangan besar untuk dapat meningkatkan capaian hit rate importasi jalur merah sebesar 40% sesuai dengan Cetak Biru Program Transformasi Kelembagaan Kementerian Keuangan Tahun 2014 – 2025 dan benchmark internasional. Melalui studi kualitatif, penelitian ini bertujuan untuk mengetahui penggunaan data mining yang diterapkan dalam risk engine berdasarkan data importasi, pengalaman orang, dan data hasil penelitian institusi kepabeanan negara lain. Metode data mining yang digunakan adalah CRISP-DM, metode klasifikasi, dan model decision tree, dengan menggunakan data importasi jalur merah Kantor Pelayanan Utama (KPU) Bea dan Cukai (BC) Tipe A Tanjung Priok periode September – Desember 2019 dan Januari 2020. Hasil penelitian menunjukkan bahwa penggunaan data mining dapat meningkatkan capaian hit rate importasi jalur merah. Atribut yang paling relevan dalam mengklasifikasikan data adalah negara pengirim yang dikategorikan sebagai root node (akar), sedangkan atribut tarif bea masuk tidak memberikan informasi dalam klasifikasi data. Penelitian ini diharapkan dapat memberikan pandangan baru bagi KPU BC Tipe A Tanjung Priok dalam upaya perbaikan risk engine targeting dan risk engine penjaluran Bea dan Cukai. Kata Kunci: CRISP-DM, data mining, decision tree, hit rate, importasi jalur merah.

The localisation, intracellular transport, and biosynthetic regulation of betalain plant pigments

<p>This thesis investigates the localisation, transport and biosynthetic control of betalain plant pigments to compare with the extensively researched anthocyanins. Anthocyanins and betalains appear similar, yet no plant naturally contains both pigment types. Due to this mutual exclusivity, betalain pigments are thought to functionally replace anthocyanins in many Caryophyllales. However, minimal research has been conducted to support this replacement hypothesis, resulting in limited knowledge of betalain pigment distribution and biosynthesis. The following series of experiments have added to this body of knowledge. Localisation of betalains was compared with that reported for anthocyanins. Histological analyses of 12 different betalain-producing species revealed similar pigment localisation to that of anthocyanic species. Similarities in pigment localisation suggest that these pigment types may have similar functional roles. The histological analyses also found that betacyanins and betaxanthins had differential localisation in several taxa. Organ- or tissue-specific distribution of betalain compounds suggests differing biological functions for betaxanthins and betacyanins. Hypotheses on betalain transport were tested using transgenic Arabidopsis thaliana lines capable of producing anthocyanins (PAP1-5), betalains (DOD-6), or both (DOD-6 x PAP1-5). Betaxanthins appeared to use vesicular transport, as betaxanthins were detected in small circular bodies within the cytoplasm. Furthermore, this observation suggests that betaxanthin formation occurred outside of the vacuole. DOD-6 was also crossed with Arabidopsis mutants, tt12 and tt19, which are deficient in proteins required for flavonoid vacuolar transport. Betaxanthin accumulation was reduced in both lines. In addition, DOD-6 was treated with transport inhibitors that affect anthocyanin accumulation. These experiments demonstrated that betaxanthins can utilise known flavonoid transport mechanisms, at least in this artificial pigment system. Regulation of betalain biosynthesis was analysed using Swiss chard (Beta vulgaris subsp. cicla cv. ‘Bright Lights’). Betalain production was induced through physical wounding of the lamina in red and white Swiss chard lines. Betalain pigments were produced around the wounding sites in the red line but not in the white line. Transcript level changes of betalain and flavonoid biosynthetic genes in these tissues were measured using real-time quantitative polymerase chain reaction analyses. Betalain biosynthetic genes were not up-regulated in the red line even though red pigments visibly accumulated. Rather, these genes were already expressed in the red line prior to wounding. Biosynthetic control of betalains may either be earlier in the pathway or at the post-transcriptional level. In contrast, all three flavonoid biosynthetic genes were up-regulated in response to wounding, indicating that expression of flavonoid and betalain biosynthetic genes are not co-regulated in Swiss chard. The final set of experiments examined the function of the two Beta vulgaris DOD genes (DODA and DODA1). Both genes were transiently expressed in nivea Antirrhinum majus dorsal petals and vacuum infiltrated with the betalain precursor L-DOPA. Expression of DODA1 but not DODA appeared to produce betalains. DODA-like genes have been found in anthocyanin-producing species, suggesting that this gene may not be involved in betalain biosynthesis. The overall findings from this research indicate that betalain pigment evolution of may have involved the utilization of anthocyanin transport machinery, but the regulatory control of the two pathways appears different.</p>

The localisation, intracellular transport, and biosynthetic regulation of betalain plant pigments

<p>This thesis investigates the localisation, transport and biosynthetic control of betalain plant pigments to compare with the extensively researched anthocyanins. Anthocyanins and betalains appear similar, yet no plant naturally contains both pigment types. Due to this mutual exclusivity, betalain pigments are thought to functionally replace anthocyanins in many Caryophyllales. However, minimal research has been conducted to support this replacement hypothesis, resulting in limited knowledge of betalain pigment distribution and biosynthesis. The following series of experiments have added to this body of knowledge. Localisation of betalains was compared with that reported for anthocyanins. Histological analyses of 12 different betalain-producing species revealed similar pigment localisation to that of anthocyanic species. Similarities in pigment localisation suggest that these pigment types may have similar functional roles. The histological analyses also found that betacyanins and betaxanthins had differential localisation in several taxa. Organ- or tissue-specific distribution of betalain compounds suggests differing biological functions for betaxanthins and betacyanins. Hypotheses on betalain transport were tested using transgenic Arabidopsis thaliana lines capable of producing anthocyanins (PAP1-5), betalains (DOD-6), or both (DOD-6 x PAP1-5). Betaxanthins appeared to use vesicular transport, as betaxanthins were detected in small circular bodies within the cytoplasm. Furthermore, this observation suggests that betaxanthin formation occurred outside of the vacuole. DOD-6 was also crossed with Arabidopsis mutants, tt12 and tt19, which are deficient in proteins required for flavonoid vacuolar transport. Betaxanthin accumulation was reduced in both lines. In addition, DOD-6 was treated with transport inhibitors that affect anthocyanin accumulation. These experiments demonstrated that betaxanthins can utilise known flavonoid transport mechanisms, at least in this artificial pigment system. Regulation of betalain biosynthesis was analysed using Swiss chard (Beta vulgaris subsp. cicla cv. ‘Bright Lights’). Betalain production was induced through physical wounding of the lamina in red and white Swiss chard lines. Betalain pigments were produced around the wounding sites in the red line but not in the white line. Transcript level changes of betalain and flavonoid biosynthetic genes in these tissues were measured using real-time quantitative polymerase chain reaction analyses. Betalain biosynthetic genes were not up-regulated in the red line even though red pigments visibly accumulated. Rather, these genes were already expressed in the red line prior to wounding. Biosynthetic control of betalains may either be earlier in the pathway or at the post-transcriptional level. In contrast, all three flavonoid biosynthetic genes were up-regulated in response to wounding, indicating that expression of flavonoid and betalain biosynthetic genes are not co-regulated in Swiss chard. The final set of experiments examined the function of the two Beta vulgaris DOD genes (DODA and DODA1). Both genes were transiently expressed in nivea Antirrhinum majus dorsal petals and vacuum infiltrated with the betalain precursor L-DOPA. Expression of DODA1 but not DODA appeared to produce betalains. DODA-like genes have been found in anthocyanin-producing species, suggesting that this gene may not be involved in betalain biosynthesis. The overall findings from this research indicate that betalain pigment evolution of may have involved the utilization of anthocyanin transport machinery, but the regulatory control of the two pathways appears different.</p>

Important Geophysical Comments for Nuclear Engineers and for the World Climate Democracy

These are important comments that give examples for physicists, geophysics specialists, climate scientists and other scientific professions as they may attempt to organize systems « playing with fire » (trying to achieve more profit by going near the red line of the accident) and offer a fair suggestion for the modern-time « climate democracy » with a Popperian proposal on a climate standard.

Screening of final beneficiaries – a red line in humanitarian operations. An emerging concern in development work

Funding agreements for humanitarian action frequently include restrictions and requirements in their grants that aim to ensure that recipients of the funding comply with counterterrorism measures and sanctions adopted by the donor. These measures can be problematic if they prevent humanitarian actors from operating in accordance with humanitarian principles or are incompatible with international humanitarian law. While attention has focused primarily on requirements in grants for humanitarian action, increasingly donors to development work have also started including sanctions- and counterterrorism-related restrictions in their grants. The present article focuses on one such measure that is currently a live concern: requirements to screen and, thus, potentially exclude final beneficiaries. It explains why these requirements go over and above what sanctions and counterterrorism measures require, and why they are inconsistent with humanitarian principles and international humanitarian law. The article also explores the position in relation to development interventions.

Nutritional Status Based on Four Anthropometric Indices and Associated Factors in Children between the Ages 0-2 Years Old in a Slum of Surabaya

Introduction: Bulak Banteng sub-district is one of the slums in Surabaya. In a study in Bulak Banteng sub-district in 2015, 6.6% of children experienced malnutrition and 3% of children with Lower Red Line status. The highest number of children with Lower Red Line status was in RW 08. This study aimed to determine the nutritional status of children aged 0-2 years old in RW 08 Bulak Banteng sub-district, Surabaya, in 2018.Methods: This study used a cross-sectional descriptive study from primary data conducted by anthropometric measurement directly on toddlers and interviews with caregivers. Assessment of four anthropometric indices includes weight-for-age, height-for-age, weight-for-height, and head circumference-for-age. A sample of 50 toddlers was taken by proportional random sampling technique.Results: 31 children (62%) aged 0-2 years old in RW 08 Bulak Banteng sub-district had normal growth status based on weight-for-age, height-for-age, weight-for-height, and head circumference-for-age. The remaining growth status of 27 children (54%) is as follows. Based on the weight-for-age index, a child (2%) was severely underweight, and 7 children (14%) were underweight. Based on the height-for-age index, 4 children (8%) were severely stunted, and 7 children (14%) were stunted. Based on the index of weight-for-height, a child (2%) was severely wasted, and 5 children (10%) were wasted. Based on the index of head circumference-for-age, there were 1 child (2%) microcephaly and 3 children (6%) macrocephaly.Conclusion: This study found that many children aged 0-2 years old in the slum area of RW 08 Bulak Banteng sub-district in Surabaya experienced growth delays.