Quality Assessment of Some Alcohol-Based Hand Sanitizers Circulating in the Federal Capital Territory, Abuja. Nigeria

Background The emergence of corona virus disease caused by SARS-COV-2 (Covid-19) and the subsequent recommendation by the World Health Organization (WHO) on the use of non-pharmaceutical measures led to an upsurge in the production and sale of hand sanitizers across the globe including Nigeria. It is important that product regulation schemes are designed in such a way as to ensure the continual quality of the products to potential clients. Hence, this paper provides an understanding of the quality of alcohol based hand sanitizers in Abuja, Nigeria. Methods A total of fifty (50) different brands of alcohol-based hand sanitizers were purchased from different pharmacies, supermarkets, and stores, within Abuja. In the laboratory, samples were checked for their label claims, NAFDAC registration number, batch number, manufacturing and expiration dates. The information was recorded in the laboratory notebook in accordance with ISO 17025 requirement, then samples were coded as SAN1 to SAN50 and assessed for pH values and Alcohol Content. Results About 40% of the circulating hand sanitizers in the market did not go through regulatory vetting, 34% of the products did not have information on the country of manufacture, 32% of the sanitizers had pH values within acceptable range, while 78% of the products contained less than 60% alcohol. Conclusion This study gives an insight into the quality of alcohol-based hand sanitizers and we suggest an urgent need for the regulatory authorities of developing countries to enhance their surveillance and control of these substandard products in the society.

“Everything Is in the Lab Book”: Multimodal Writing, Activity, and Genre Analysis of Symbolic Mediation in Medical Physics

Writing and genre scholarship has become increasingly attuned to how various nontextual features of written genres contribute to the kinds of social actions that the genres perform and to the activities that they mediate. Even though scholars have proposed different ways to account for nontextual features of genres, such attempts often remain undertheorized. By bringing together Writing, Activity, and Genre Research, and Multimodal Interaction Analysis, the authors propose a conceptual framework for multimodal activity-based analysis of genres, or Multimodal Writing, Activity, and Genre (MWAG) analysis. Furthermore, by drawing on previous studies of the laboratory notebook (lab book) genre, the article discusses the rhetorical action the genre performs and its role in mediating knowledge construction activities in science. The authors provide an illustrative example of the MWAG analysis of an emergent scientist’s lab book and discuss its contributions to his increasing participation in medical physics. The study contributes to the development of a theoretically informed analytical framework for integrative multimodal and rhetorical genre analysis, while illustrating how the proposed framework can lead to the insights into the sociorhetorical roles multimodal genres play in mediating such activities as knowledge construction and disciplinary enculturation.

Pilot Study of an Electronic Laboratory Notebook for Research and Development

The laboratory notebook is the fundamental record for research and development. The emergence of cloud-based digital tools to replace or augment the laboratory notebook has shown promise for groups that are multidisciplinary, working asynchronously, or in multiple locations. This paper details a recent pilot study conducted by Sandia National Laboratories (SNL) comparing an electronic lab notebook (ELN) with traditional paper lab notebooks (PLN), including members of SNL’s Primary Standards Laboratory (PSL). Partly motivated by a related pilot study conducted at the National Institute of Standards and Technology (NIST), the focus of the present study was on the integrability of an ELN within the unique constraints of a national lab, including security protocols that limit cloud capabilities and limited WIFI. The study used Microsoft OneNote and commercially available mobile computing hardware. The pilot included 18 participants from the PSL, biosciences, and materials science/engineering labs. In addition to OneNote, participants were provided one of two options for a computer to be used as their note taking device (including a stylus). Usability and gap analyses, as well as interviews with pilot participants were conducted by members from Sandia’s human factors group. Findings from this study indicate that ELNs may be particularly useful for teams where sharing of procedures and results is important. Participants believed that use of the ELN increased organization of their work and facilitated reporting much more than paper lab notebooks (PLNs). Other benefits included searchability and capability for access on multiple devices. Many of the identified drawbacks were specific to the unique constraints of working at a national lab, but some constraints are more general (e.g. use of ELNs in wet labs where hazardous materials may be of concern). Overall, it was found with proper training, collaboration on best practices, and technical support, that ELNs appear to be a promising tool for modernizing recording practices in research. Some examples from PSL will be highlighted, including R&D for qualifying measurement systems, calibration processes, and procedures.

Elegancy: An open-source and intuitive cloud-based electronic laboratory notebook

We introduce an electronic laboratory notebook, Elegancy, a cloud-based and standalone web service distributed as a Docker image. Elegancy allows researchers to digitize and safeguard their documentations in laboratories. It helps the scholarly community in gathering evidence, sharing information, reorganizing knowledge, and creating laboratory works with greater ease and security.

Finding Connections in Policies Covering Electronic Laboratory Notebook Retention and Transferal

Objective: As electronic laboratory notebook (ELN) capability continues to expand, more researchers are turning to this digital format. The University of Massachusetts Medical School developed new guidelines to outline the retention and transferal of ELNs. How do other universities approach the retention and transferal of laboratory notebooks, including ELNs? Methods: The websites of 25 universities were searched for policies or guidelines on laboratory notebook retention and transferal. A textual analysis of the policies was performed to find common themes. Results: Information on the retention and transferal of laboratory notebooks was found in record retention and research data policies/guidelines. Out of the 25 institutional websites searched, 16 policies/guidelines on research notebook retention were found and 10 institutions had policies/guidelines on transferring research notebooks when a researcher leaves the university. Only one policy had a retention recommendation for storage location specific to electronic media, including laboratory notebooks, that did not apply to its paper counterparts, the remaining policies either explicitly include multiple forms and media or do not mention multiple formats for research records at all. The minimum number of years of retention for research notebooks ranged from immediately after report completion to 7 years after completing the research with the possibility of extension depending on a wide range of external requirements. Most research notebook transferal policies and guidelines required associated researchers and students to request permission from their principal investigator (PI) before taking a copy of the notebook. Most institutions with policies also seek to retain access to research notebooks when a PI leaves an institution to protect intellectual property and respond to any cases of scientific misconduct or conflict of interest. Conclusions: Other universities have a range of approaches for the retention and transferal of laboratory notebooks, but most provide the same recommendations for both electronic and physical laboratory notebooks in their research data or record retention policies/guidelines.

Tele-Substitution Reactions in the Synthesis of a Promising Class of Antimalarials

<p></p><p>We have discovered and studied a <i>tele</i>substitution reaction in a biologically important heterocyclic ring system. Conditions that favour the <i>tele</i>-substitution pathway were identified: the use of increased equivalents of the nucleophile or decreased equivalents of base, or the use of softer nucleophiles, less polar solvents and larger halogens on the electrophile. Using results from X-ray crystallography and isotope labelling experiments a mechanism for this unusual transformation is proposed. We focused on this triazolopyrazine as it is the core structure of the <i>in vivo </i>active anti-plasmodium compounds of Series 4 of the Open Source Malaria consortium.</p> <p> </p> <p>Archive of the electronic laboratory notebook with the description of all conducted experiments and raw NMR data could be accessed via following link <a href="https://ses.library.usyd.edu.au/handle/2123/21890">https://ses.library.usyd.edu.au/handle/2123/21890</a> . For navigation between entries of laboratory notebook please use file "Strings for compounds in the article.pdf" that works as a reference between article codes and notebook codes, also this file contain SMILES for these compounds. </p><br><p></p>

Tele-Substitution Reactions in the Synthesis of a Promising Class of Antimalarials

<p></p><p>We have discovered and studied a <i>tele</i>substitution reaction in a biologically important heterocyclic ring system. Conditions that favour the <i>tele</i>-substitution pathway were identified: the use of increased equivalents of the nucleophile or decreased equivalents of base, or the use of softer nucleophiles, less polar solvents and larger halogens on the electrophile. Using results from X-ray crystallography and isotope labelling experiments a mechanism for this unusual transformation is proposed. We focused on this triazolopyrazine as it is the core structure of the <i>in vivo </i>active anti-plasmodium compounds of Series 4 of the Open Source Malaria consortium.</p> <p> </p> <p>Archive of the electronic laboratory notebook with the description of all conducted experiments and raw NMR data could be accessed via following link <a href="https://ses.library.usyd.edu.au/handle/2123/21890">https://ses.library.usyd.edu.au/handle/2123/21890</a> . For navigation between entries of laboratory notebook please use file "Strings for compounds in the article.pdf" that works as a reference between article codes and notebook codes, also this file contain SMILES for these compounds. </p><br><p></p>

Towards reproducible computational drug discovery

The reproducibility of experiments has been a long standing impediment for further scientific progress. Computational methods have been instrumental in drug discovery efforts owing to its multifaceted utilization for data collection, pre-processing, analysis and inference. This article provides an in-depth coverage on the reproducibility of computational drug discovery. This review explores the following topics: (1) the current state-of-the-art on reproducible research, (2) research documentation (e.g. electronic laboratory notebook, Jupyter notebook, etc.), (3) science of reproducible research (i.e. comparison and contrast with related concepts as replicability, reusability and reliability), (4) model development in computational drug discovery, (5) computational issues on model development and deployment, (6) use case scenarios for streamlining the computational drug discovery protocol. In computational disciplines, it has become common practice to share data and programming codes used for numerical calculations as to not only facilitate reproducibility, but also to foster collaborations (i.e. to drive the project further by introducing new ideas, growing the data, augmenting the code, etc.). It is therefore inevitable that the field of computational drug design would adopt an open approach towards the collection, curation and sharing of data/code.