On the question of the significance of tissue decay products. Experiments with the prostate gland

At present, treatment with animal drugs (opotherapy) has become widespread. There are hundreds of such drugs under a wide variety of names and sometimes with a completely unknown composition.

Current challenges in targeting tumor desmoplasia to improve the efficacy of immunotherapy

Desmoplasia is crucial for the development, progression and treatment of immune-resistant malignancies. and treatment of immune-resistant malignancies. Targeting desmoplasia-related metabolic pathways appears to be an interesting approach to expand our stock of disposable anti-tumor agents.CXCL12/CXCR4 axis inhibition reduces fibrosis, alleviates immunosuppression and significantly enhances the efficacy of PD-1 immunotherapy. CD40L substitute therapy may increase the activity of T-cells, downregulate CD40+, prolong patients’ survival and prevent cancer progression. Although FAPα antagonists used in preclinical models did not lead to permanent cure, an alleviation of immune-resistance, modification of desmoplasia and a decrease in angiogenesis were observed. Targeting DDR2 may enhance the effect of anti-PD-1 treatment in multiple neoplasm cell lines and has the ability to overcome the adaptation to BRAF-targeted therapy in melanoma. Reprogramming desmoplasia could potentially cooperate not only with present treatment, but also other potential therapeutic targets. We present the most promising metabolic pathways related to desmoplasia and discuss the emerging strategies to improve the efficacy of immunotherapy.

Diet Mechanistic Philosophy

This chapter compares and contrasts the black-boxing approach with the “new wave of mechanistic philosophy.” Is the present treatment of black boxes novel and original? Or is it a rehashing of ideas that have been on the table since the turn of the new millennium? The black-boxing recipe fits in quite well with the depiction of science being in the business of discovering and modeling mechanisms. All three steps underlying the construction of a black box have been stressed, in some form or degree, in the extant literature. Nevertheless, the construction of black boxes, as presented here, dampens many of the ontological implications that characterize the contemporary landscape. This allows one to respond to some objections raised against the traditional mechanism. For this reason, the author provocatively refers to black-boxing as a “diet” mechanistic philosophy, with all the epistemic flavor of the old-fashioned mechanistic view, but hardly any metaphysical calories.

Effect of Selenium on TNAZ Molecule - A DFT Treatment

The present treatment deals with an unusual composite of TNAZ that is TNAZ+ nSe(n:1,2) within the constraints of density functional theory at the level of UB3LYP/6-31++G(d,p). TNAZ is an insensitive high explosive material. Since, selenium atom in its ground state has two unpaired electrons, the composites are considered in their singlet, triplet and quintet states. Selenium and TNAZ interact at different extents and the systems are electronically stable but TNAZ+2Se (singlet) structurally decomposes by the elongation of one of the geminally substituted nitro groups. Modeling studies indicate that the N-O bond elongation in the composite mentioned occurs only if azetidine ring is present with or without the nitramine bond. For the composites various structural, electronic and quantum chemical data have been harvested and discussed.

A taxonomic revision of Gaultheria series Trichophyllae (Ericaceae)

The last taxonomic revision of Gaultheria series Trichophyllae (Ericaceae), a clade of high-elevation species endemic to the Himalaya-Hengduan Shan region of east-central Asia, was published in 1941. Since then, a number of new species have been described and other taxonomic changes have occurred in the group, prompting the need for a comprehensive revision. The present treatment of the series comprises 21 species, including Gaultheria x biluoensis, a newly described hybrid between G. crassifolia and G. major. A key to species and species descriptions is provided, and lectotypes are newly designated for G. cardiosepala, G. gonggashanensis, G. marronina, and G. stenophylla.

Efficacy and Safety of Voriconazole in the treatment of resistant cases of Dermatophytosis

This is a descriptive type of longitudinal study conducted among Hundred clinically diagnosed cases of dermatophytes attending at skin out patients department of Zainul Haque Sikder Women’s Medical College, Bangladesh from August 2018 to August 2019 to observe the efficacy and safety of voriconazole among the resistant cases of dermatophytosis. Among 100 patients, 40 were males and 60 females between ages 20 and 65 years of all age group with clinical, mycological diagnosis of dermatophytosis. To find out antifungal resistance pattern as well as efficacy and Safety of Voriconazole among dermatophytes. (Skin, hair and nail samples were taken aseptically. All patients were resistant against present treatment options like: fluconazole, itraconazole & terbinafine etc.) All patients were treated with Voriconazole. Duration of treatment of each patient was 4 weeks. Resistance against fluconazole and terbinafine was most common, 85.33% and 58% respectively. 5% resistance against voriconazole was observed in this study. Resistance against fluconazole was noted among all species of dermatophytes, followed by terbinafine. Among 100 patients 80% was fully cure and rest of 15 % were partially cure with 5% resistant of Voriconazole which is seems to be more effective and safer against dermatophytosis.

Synopsis of the genus Pycnolejeunea (Spruce) Schiffn. (Lejeuneaceae, Marchantiophyta) in Brazil

ABSTRACT Pycnolejeunea is a pantropical genus represented in Brazil by nine species, according to the present treatment. Pycnolejeunea chocoensis M.E. Reiner & Gradst., recently described for Colombia, is being cited for the first time for Brazil. Descriptions are given for all species and illustrations only for Pycnolejeunea chocoensis, Pycnolejeunea contigua (Nees) Grolle, Pycnolejeunea papillosa X.-L. He and Pycnolejeunea porrectilobula C.J. Bastos & O. Yano. A key to the species of Pycnolejeunea occurring in Brazil is also presented.

Special Topics in Contact Sport Athletes and Others Who Have Had Multiple Concussions and Subconcussive Impacts

When to retire from contact sports? Help the patient, family, and peers think through the decision carefully. Educate them about the risk of serious and currently untreatable long-term problems, such as chronic traumatic encephalopathy. Discuss potential for a future professional sports career versus other career, interpersonal, and family aspirations. Does the patient have Chronic Traumatic Encephalopathy (CTE)? There is no way to tell for sure while the patient is alive. High-risk features may include progressive worsening over time, prominent mood and behavioral abnormalities, parkinsonism, and a cavum septum pellucidum on magnetic resonance imaging (MRI) scan. At present, treatment is entirely based on relieving symptoms and keeping the patient safe.

EKSPANSI ABSES BUKAL SINISTRA KEARAH COLLI DAN THORAKS DISERTAI PERFORASI GASTER

Background: Abscess is infection caused of anerob bacteria. Maxillofacialabcess aetiology was oral focus infection like dental gangren. Unproportionaltreatment could make complication that makes sistemic condition patient worst,gaster perforation. Objective : to present treatment bucal abscess case thatexpanding to colli, thoraks and complication based on mistherapy about NSAIDwith gaster perforation.Case and management: A 59 years old man with chief complain colli abscessand suspect gaster perforation with diffuse abdominal pain and distensiongaster since three days. Intraoral inspection was multipel dental gangren.Ultrasonography showed gaster perforation. Incicion drainase was done anderadication oral focus infection with repair gaster perforation under generalanaesthesia prosedure. Medication treatment with ceftriaxone injection 2x1 gram, and paracetamol infus 3x 500 mg. Bacteria kulture was negatif andhospitalization patient until 1 week.Discussion: Gold standart abscess therapy is incision drainase, but there wereclinician not aware abiut that and choosed konservative treatment with antibioticand analgesic, so that less maximal theraphy. Complication NSAID analgesicwas gaster iritation, so unproportional drug treatment can lead gaster ulcerationor perforation.Conclusion: It is important and consider drug choise for abscess treatment toavoid worst complication development