IP3-mediated Ca2+ release regulates atrial Ca2+ transients and pacemaker function by stimulation of adenylyl cyclases
2021 ◽
Vol 320
(1)
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pp. H95-H107
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Keyword(s):
This study provides evidence supporting the proposal that IP3 signaling in cardiac atria and sinoatrial node involves stimulation of Ca2+-activated adenylyl cyclases (AC1 and AC8) by IP3-evoked Ca2+ release from junctional sarcoplasmic reticulum. AC8 and IP3 receptors are shown to be located close together, while AC1 is nearby. Greater understanding of these novel aspects of the IP3 signal transduction mechanism is important for future study in atrial physiology and pathophysiology, particularly atrial fibrillation.
1994 ◽
Vol 135
(1)
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pp. 113-119
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Keyword(s):
1992 ◽
Vol 89
(1-2)
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pp. 1-9
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1977 ◽
Vol 35
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pp. 582-583
1971 ◽
Vol 29
◽
pp. 570-571
1998 ◽
Vol 31
(2)
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pp. 422A
1989 ◽
Vol 62
(04)
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pp. 1116-1120
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Keyword(s):
2014 ◽
Vol 15
(10)
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pp. 916-926
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1987 ◽
Vol 262
(6)
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pp. 2719-2728
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