mixed ester
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2022 ◽  
Vol 1049 ◽  
pp. 218-223
Author(s):  
Aleksandr S. Kazachenko ◽  
Yuriy N. Malyar ◽  
Anna S. Kazachenko

Sulfated derivatives of polysaccharides have anticoagulant, hypolipedimic and other biological activity. In this work, a complex mixed ester of galactomannan, its sulfate-citrate, was obtained for the first time. The introduction of citrate and sulfate groups was proved by FTIR spectroscopy by the appearance of corresponding absorption bands. It was shown by X-ray diffraction that the introduction of the citrate group leads to the amorphization of the galactomannan structure.


2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Muhammad Rashid ◽  
Hummera Rafique ◽  
Sadia Roshan ◽  
Shazia Shamas ◽  
Zafar Iqbal ◽  
...  

A series of halo-substituted mixed ester/amide-based analogues 4a-l have been prepared as jack bean urease inhibitor, which showed good to excellent inhibition of enzyme activity. The role of halo-substituted benzoyl moieties and alkyl substituted anilines in urease inhibitory kinetics was also investigated. The alkyl-substituted anilines 1a–b reacted with chloroacetyl chloride to afford intermediates 2a-b, which were then reacted with different halo-substituted benzoic acids 3a–f to prepare the title compounds 4a-l. The chemical structures of final products 4a-l were ascertained by FTIR, 1H NMR, 13C NMR, and mass spectra. The compound 4b showed remarkable activity with IC50 1.6 ± 0.2  nM, better than the standard thiourea having IC50 472.1 ± 135.1  nM. The 2-chloro-substituted phenyl ring on one side of compound 4b and 4-isopropyl-substituted benzene on the other side play an essential role in inhibition of urease activity. Lineweaver–Burk plots (kinetics study) indicated about 4b derivative as a mixed type of inhibitor. The virtual screening performed against urease enzyme (PDBID 4H9M) showed that compounds 4b and 4e have binding energies of −7.8 and −7.9 Kcal/mol, respectively. Based upon our results, it was found that derivative 4b is a highly potent urease inhibitor, better than the standard thiourea.


2015 ◽  
Vol 44 (2) ◽  
pp. 787-794 ◽  
Author(s):  
Tae Hwan Noh ◽  
Woosik Hong ◽  
Haeri Lee ◽  
Ok-Sang Jung
Keyword(s):  

A series of octahedral nanocages with ester, amide, and mixed ester/amide spacers in construction and valuable functions have been investigated.


2011 ◽  
Vol 90 (3) ◽  
pp. 546-556 ◽  
Author(s):  
Anca Simioniuc ◽  
Manuela Campan ◽  
Vincenzo Lionetti ◽  
Martina Marinelli ◽  
Giovanni D. Aquaro ◽  
...  
Keyword(s):  

Polymer ◽  
2010 ◽  
Vol 51 (16) ◽  
pp. 3774-3783 ◽  
Author(s):  
Lili Li ◽  
Margaret Frey

2005 ◽  
Vol 82 (3) ◽  
pp. 336-340 ◽  
Author(s):  
Yixiang Xu ◽  
Vesselin Miladinov ◽  
Milford A. Hanna

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