RESULTS OF INSPECTION OF THE STATE OF PROVIDING THE MICROCLIMATE IN THE PIG FARM WITH A NEGATIVE PRESSURE VENTILATION SYSTEM

The most popular microclimate system today is based on a negative pressure ventilation system. Because it is easier to use and consumes less energy than any other forced ventilation system. The purpose of the research is to inspect the room for keeping piglets on rearing with a negative pressure ventilation system to identify shortcomings and deviations of the microclimate parameters necessary for further improvement. According to the results of the inspection of the rearing room for piglets, it was found that according to the existing system of negative pressure in the rearing room for piglets, most indicators (air velocity, ammonia, carbon dioxide, hydrogen sulfide, oxygen) are within normal limits. According to the results of the inspection of the room for keeping piglets for rearing with a negative pressure microclimate system, it was found that the air temperature in the room does not meet the recommended limits and reaches 30 °C, while the maximum recommended temperature for piglets for fattening is 20 °C. The air temperature is uneven along the length of the room, which is caused by uneven air supply from the vents. According to the results of the inspection of the room for piglets with a negative pressure microclimate system, it was found that the relative humidity at the height of the animals is higher than the recommended norms and reaches 95%, while the recommended humidity for piglets for fattening is not more than 80%. According to the results of the inspection of the room for keeping piglets for rearing with a negative pressure microclimate system, it can be stated that it is necessary to improve the air cooling system and replan the ventilation ducts of the ventilation system to ensure even air flow.

Clinical transplantation using negative pressure ventilation ex situ lung perfusion with extended criteria donor lungs

Lung transplantation remains the best treatment option for end-stage lung disease; however, is limited by a shortage of donor grafts. Ex situ lung perfusion, also known as ex vivo lung perfusion, has been shown to allow for the safe evaluation and reconditioning of extended criteria donor lungs, increasing donor utilization. Negative pressure ventilation ex situ lung perfusion has been shown, preclinically, to result in less ventilator-induced lung injury than positive pressure ventilation. Here we demonstrate that, in a single-arm interventional study (ClinicalTrials.gov number NCT03293043) of 12 extended criteria donor human lungs, negative pressure ventilation ex situ lung perfusion allows for preservation and evaluation of donor lungs with all grafts and patients surviving to 30 days and recovered to discharge from hospital. This trial also demonstrates that ex situ lung perfusion is safe and feasible with no patients demonstrating primary graft dysfunction scores grade 3 at 72 h or requiring post-operative extracorporeal membrane oxygenation.

Negative pressure ventilation as a bridge to lung transplant

ABSTRACT Recent years have witnessed evolution of lung allocation strategies to prioritize sicker recipients. In the pre-transplant period, this has translated into increased utilization of invasive extracorporeal or mechanical ventilatory support as a bridge to lung transplantation. The morbidity associated with these strategies warrants consideration to less invasive respiratory support modalities. Herein, we present a case highlighting successful bridge to lung transplantation with a relatively non-invasive negative pressure ventilator.