Impact of skull sutures, spongiform bone distribution, and aging skull conductivities on the EEG forward and inverse problems

Source imaging is a principal objective for electroencephalography (EEG), the solutions of which require forward problem (FP) computations characterising the electric potential distribution on the scalp due to known sources. Additionally, the EEG-FP is dependent upon realistic, anatomically correct volume conductors and accurate tissue conductivities, where the skull is particularly important. Skull conductivity, however, deviates according to bone composition and the presence of adult sutures. The presented study therefore analyses the effect the presence of adult sutures and differing bone composition have on the EEG-FP and inverse problem (IP) solutions. Utilising a well-established head atlas, detailed head models were generated including compact and spongiform bone and adult sutures. The true skull conductivity was considered as inhomogeneous according to spongiform bone proportion and sutures. The EEG-FP and EEG-IP were solved and compared to results employing homogeneous skull models, with varying conductivities and omitting sutures, as well as using a hypothesised aging skull conductivity model. Significant localised FP errors, with relative error up to 85%, were revealed, particularly evident along suture lines and directly related to the proportion of spongiform bone. This remained evident at various ages. Similar EEG-IP inaccuracies were found, with the largest (maximum 4.14 cm) across suture lines. It is concluded that modelling the skull as an inhomogeneous layer that varies according to spongiform bone proportion and includes differing suture conductivity is imperative for accurate EEG-FP and source localisation calculations. Their omission can result in significant errors, relevant for EEG research and clinical diagnosis.

Matched Field Processing for complex Earth structure

Matched Field Processing (MFP) is a technique to locate the source of a recorded wave field. It is the generalization of beamforming, allowing for curved wavefronts. In the standard approach to MFP, simple analytical Green's functions are used as synthetic wave fields that the recorded wave fields are matched against. We introduce an advancement of MFP by utilizing Green's functions computed numerically for real Earth structure as synthetic wave fields. This allows in principle to incorporate the full complexity of elastic wave propagation, and through that provide more precise estimates of the recorded wave field's origin. This approach also further emphasizes the deep connection between MFP and the recently introduced interferometry-based source localisation strategy for the ambient seismic field. We explore this connection further by demonstrating that both approaches are based on the same idea: both are measuring the (mis-)match of correlation wave fields. To demonstrate the applicability and potential of our approach, we present two real data examples, one for an earthquake in Southern California, and one for secondary microseism activity in the Northeastern Atlantic and Mediterranean Sea. Tutorial code is provided to make MFP more approachable for the broader seismological community.

A novel method for asynchronous source localisation based on time of arrival measurements

Source localisation is an important component in the application of wireless sensor networks, and plays a key role in environmental monitoring, healthcare and battlefield surveillance and so on. In this article, the source localisation problem based on time-of-arrival measurements in asynchronous sensor networks is studied. Because of imperfect time synchronisation between the anchor nodes and the signal source node, the unknown parameter of start transmission time of signal source makes the localisation problem further sophisticated. The derived maximum-likelihood estimator cost function with multiple local minimum is non-linear and non-convex. A novel two-step method which can solve the global minimum is proposed. First, by leveraging dimensionality reduction, the maximum (minimum) distance maximum (minimum) time-of-arrival matching-based second-order Monte Carlo method is applied to find a rough initial position of the signal source with low computational complexity. Then, the rough initial position value is refined using trust region method to obtain the final positioning result. Comparative analysis with state-of-the-art semidefinite programming and min–max criterion-based algorithms are conducted. Simulations show that the proposed method is superior in terms of localisation accuracy and computational complexity, and can reach the optimality benchmark of Cramér–Rao Lower Bound even in high signal-to-noise ratio environments.

A multi‐site, multi‐participant magnetoencephalography resting‐state dataset to study dementia: The BioFIND dataset

Early detection of Alzheimers Disease (AD) is vital to reduce the burden of dementia and for developing effective treatments. Neuroimaging can detect early brain changes, such as hippocampal atrophy in Mild Cognitive Impairment (MCI), a prodromal state of AD. However, selecting the most informative imaging features by machine-learning requires many cases. While large publically-available datasets of people with dementia or prodromal disease exist for Magnetic Resonance Imaging (MRI), comparable datasets are missing for Magnetoencephalography (MEG). MEG offers advantages in its millisecond resolution, revealing physiological changes in brain oscillations or connectivity, before structural changes are evident with MRI. We introduce a MEG dataset with 324 individuals: patients with MCI and healthy controls. Their brain activity was recorded while resting with eyes closed, using a 306-channel MEG scanner at one of two sites (Madrid or Cambridge), enabling tests of generalization across sites. A T1-weighted MRI is provided to assist source localisation. The MEG and MRI data can be formatted according to international BIDS standards, and analysed freely on the DPUK platform (https://portal.dementiasplatform.uk/Apply).