Polarity Sensitivity of Human Auditory Nerve Fibers Based on Pulse Shape, Cochlear Implant Stimulation Strategy and Array

Neural health is of great interest to determine individual degeneration patterns for improving speech perception in cochlear implant (CI) users. Therefore, in recent years, several studies tried to identify and quantify neural survival in CI users. Among all proposed techniques, polarity sensitivity is a promising way to evaluate the neural status of auditory nerve fibers (ANFs) in CI users. Nevertheless, investigating neural health based on polarity sensitivity is a challenging and complicated task that involves various parameters, and the outcomes of many studies show contradictory results of polarity sensitivity behavior. Our computational study benefits from an accurate three-dimensional finite element model of a human cochlea with realistic human ANFs and determined ANF degeneration pattern of peripheral part with a diminishing of axon diameter and myelination thickness based on degeneration levels. In order to see how different parameters may impact the polarity sensitivity behavior of ANFs, we investigated polarity behavior under the application of symmetric and asymmetric pulse shapes, monopolar and multipolar CI stimulation strategies, and a perimodiolar and lateral CI array system. Our main findings are as follows: (1) action potential (AP) initiation sites occurred mainly in the peripheral site in the lateral system regardless of stimulation strategies, pulse polarities, pulse shapes, cochlear turns, and ANF degeneration levels. However, in the perimodiolar system, AP initiation sites varied between peripheral and central processes, depending on stimulation strategies, pulse shapes, and pulse polarities. (2) In perimodiolar array, clusters formed in threshold values based on cochlear turns and degeneration levels for multipolar strategies only when asymmetric pulses were applied. (3) In the perimodiolar array, a declining trend in polarity (anodic threshold/cathodic threshold) with multipolar strategies was observed between intact or slight degenerated cases and more severe degenerated cases, whereas in the lateral array, cathodic sensitivity was noticed for intact and less degenerated cases and anodic sensitivity for cases with high degrees of degeneration. Our results suggest that a combination of asymmetric pulse shapes, focusing more on multipolar stimulation strategies, as well as considering the distances to the modiolus wall, allows us to distinguish the degeneration patterns of ANFs across the cochlea.

The Processing of Negation and Polarity: An Overview

Negation is a universal component of human language; polarity sensitivity (i.e., lexical distributional constraints in relation to negation) is arguably so while being pervasive across languages. Negation has long been a field of inquiry in psychological theories and experiments of reasoning, which inspired many follow-up studies of negation and negation-related phenomena in psycholinguistics. In generative theoretical linguistics, negation and polarity sensitivity have been extensively studied, as the related phenomena are situated at the interfaces of syntax, semantics and pragmatics, and are thus extremely revealing about the architecture of grammar. With the now long tradition of research on negation and polarity in psychology and psycholinguistics, and the emerging field of experimental semantics and pragmatics, a multitude of interests and experimental paradigms have emerged which call for re-evaluations and further development and integration. This special issue contains a collection of 16 research articles on the processing of negation and negation-related phenomena including polarity items, questions, conditionals, and irony, using a combination of behavioral (e.g., rating, reading, eye-tracking and sentence completion) and neuroimaging techniques (e.g., EEG). They showcase the processing of negation and polarity with or without context, in various languages and across different populations (adults, typically developing and ADHD children). The integration of multiple theoretical and empirical perspectives in this collection provides new insights, methodological advances and directions for future research.

Processing of the Mandarin polarity item renhe ‘any’

The Mandarin renhe is similar to the English any in terms of polarity sensitivity (Wang 1993; Wang & Hsieh 1996; Kuo 2003; Cheng & Giannakidou 2013; Shyu 2016). However, the following phenomena regarding any in relative clause environments have not been surveyed with respect to renhe: (a) the NPI illusion effect reported in studies like Parker & Phillips (2011; 2016); (b) the subtrigging effect discussed in LeGrand (1975) and Dayal (1998; 2004). We conducted two untimed, offline acceptability judgment experiments and the results suggest that: (i) NPI illusion does not appear in Mandarin in untimed offline processing, (ii) the subtrigging effect of renhe holds, and (iii) renhe can be licensed by certain types of declarative verbs like tongyi ‘agree’ and zancheng ‘approve’. The results confirm the strict structural requirement of the c-commanding relation between a negation licensor and renhe (Wang 1993) and the licensing of renhe in non-veridical contexts (Cheng & Giannakidou 2013), and further suggest additional licensing environments for renhe: relative clauses and declarative verbs. This requires reconsideration of positing non-veridicality as a necessary licensing condition for renhe and calls for future research on how renhe is licensed under these two licensing environments.

Superlative-modified numerals and negation: A multiply negotiable cost

Comparative-modified numerals (CMNs) and superlative-modified numerals (SMNs) are reported to exhibit a polarity sensitivity contrast: unlike CMNs, the use of SMNs is said to be sensitive to embedding under negation. This contrast is however neither well studied nor well understood, such that the existing views in the literature disagree vastly on both the basic facts and related expectations. In this paper we investigate this contrast in three offline experiments. We show that there is strong empirical support for this reported contrast under negation, but none of the existing analyses of the contrast can capture it in full, though we do seem to require insights from each.

Issues in the Syntax of Polarity-Sensitive Items

This chapter provides an overview of PSIs (polarity-sensitive items) in Arabic and briefly outlines the critical issues in the syntax of PSIs in Arabic and their contributions to Arabic syntax and linguistic theory. It also outlines the theoretical underpinnings of research on Arabic negation, relying on the author’s most recent publications. The author synthesizes the major and crucial findings from cross-linguistic studies on this topic and studies of PSIs in Arabic. This chapter also articulates the critical issues, methodology, and scope of content. A quick overview of polarity sensitivity reveals much of the microvariation in Arabic. Geographically, this variation comparatively grows at the phonetic, morphological, and lexical levels, moving from the west with the Moroccan dialect, into Egyptian and Jordanian along the Mediterranean, into the Arabian Peninsula with Qatari Arabic, and into the formal written Arabic.

A Unified Theory of Polarity Sensitivity

This book examines polarity sensitivity—a ubiquitous phenomenon involving expressions such as anybody, nobody, ever, never, and somebody and their counterparts in other languages, with particular focus on Arabic. These expressions belong to different classes such as negative and positive polarity, negative concord, and negative indefinites, which led to examining their syntax and semantics separately. In this book, Ahmad Alqassas pursues a unified approach that relies on examining the interaction between the various types of polarity sensitivity. Treating this interaction is fundamental for scrutinizing their licensing conditions. Alqassas draws on data from Standard Arabic and the major regional dialects represented by Jordanian, Egyptian, Moroccan, and Qatari. The book provides a new perspective on the syntax–semantic interface and develops a unified syntactic analysis for polarity sensitivity. Through the (micro)comparative approach, Alqassas explains the distributional contrasts with a minimal set of universal syntactic operations such as Merge, Move, and Agree, and a fine-grained inventory of negative formal features for polarity items and their licensors. The features are simple invisibles that paint a complex landscape of polarity. The results suggest that syntactic computation of Arabic polarity (externally merged in the left periphery) is subservient to the conceptual–intentional interface. Alqassas argues for last resort insertion of covert negation operators in the CP layer to interpret non-strict NCIs, which is an extra mechanism that serves the semantic interface but adds to the complexity of syntactic computation. Likewise, head NPIs in the left periphery require licensing by operators higher than the tense phrase, adding more constraints on the syntactic licensing.

Dynamic presupposition of want and polarity sensitivity

In this paper, I argue that content of some presuppositions is determined dynamically. In particular, it is shown that the presupposition of want in control constructions depends on the interpretation of an action in the complement clause. Different presuppositional content of sentences with want is argued for using new and known observations about licensing of Polarity Sensitive Items. I propose to capture the dynamic nature of the presupposition of want using the AGM paradigm for belief revision (Alchourrán, Gärdenfors & Makinson 1985). Finally, I show that sensitivity to the interpretation of an action as intentional versus accidental is not specific to polarity system, but can be found across different domains of the grammar in many unrelated languages.

New β-diketone-boron difluoride based near-infrared fluorescent probes for polarity

Two new β-diketone-boron difluoride based near-infrared fluorescent probes 1 and 2 which exhibit polarity sensitivity have been designed and synthesized. Probes 1 and 2 are composed of β-diketone-boron difluoride moiety...