A fatigue life prediction tool was developed for caliper guide pins under random vibrational loading. The Pie-Slice model was designed to provide detailed information about the failure location, orientation, and damage magnitude. A component test fixture was developed to determine the strain-life curve for a given guide pin design. Statistical analysis was conducted to insure the repeatability of the failure mode and the robustness of the setup. Weibull analysis was performed to the measured guide pin strain-life in order to insure that the developed strain-life data to insure that developed strain-life curve will account for all the manufacturing process variations, from a component, assembly, and a system level to a certain level of reliability and confidence. Rainflow cycle count was used to bin the damaging and non-damaging cycles based on their stain level. Fatigue life calculation was performed using the Smith-Watson-Topper strain-life approach. The predictive tool was able to accurately estimate the cumulative fatigue damage for guide pins under random loading conditions. The Pie-Slice model was also able to predict the failure location and orientation of a crack, as well as the damage magnitude. Both tools were validated using a pre-designed random block-load sequence at constant amplitude..