Many disorders of vision and hearing are concomitant with the growing elderly demographic, and conditions of the eyes, ears, nose, and throat are often associated with other health states. Whilst ophthalmic and ear, nose, and throat (ENT) interventions are largely the domain of distinct clinical specialisms, general adult nurses are likely to encounter people with eyes and ENT conditions across all care settings. This chapter outlines key facts about eye and vision disorders and ENT conditions which are likely to be useful to the general nurse. These include an overview of common conditions, investigations, and treatments. The chapter also includes short sections of key facts related to ophthalmic and ENT surgery. Important nursing considerations for decision-making and practice are outlined, and an overview of frequently prescribed medications is presented in a summary table.