Info-metrics is a framework for modeling, reasoning, and drawing inferences under conditions of noisy and insufficient information. It is an interdisciplinary framework situated at the intersection of information theory, statistical inference, and decision-making under uncertainty. In a recent book on the Foundations of Info-Metrics, Golan (OUP, 2018) provides the theoretical underpinning of info-metrics and the necessary tools and building blocks for using that framework. This volume complements Golan’s book and expands on the series of studies on the classical maximum entropy and Bayesian methods published in the different proceedings started with the seminal collection of Levine and Tribus (1979) and continuing annually. The objective of this volume is to expand the study of info-metrics, and information processing, across the sciences and to further explore the basis of information-theoretic inference and its mathematical and philosophical foundations. This volume is inherently interdisciplinary and applications oriented. It contains some of the recent developments in the field, as well as many new cross-disciplinary case studies and examples. The emphasis here is on the interrelationship between information and inference where we view the word ‘inference’ in its most general meaning – capturing all types of problem solving. That includes model building, theory creation, estimation, prediction, and decision making. The volume contains nineteen chapters in seven parts. Although chapters in each part are related, each chapter is self-contained; it provides the necessary tools for using the info-metrics framework for solving the problem confronted in that chapter. This volume is designed to be accessible for researchers, graduate students, and practitioners across the disciplines, requiring only some basic quantitative skills. The multidisciplinary nature and applications provide a hands-on experience for the reader.