Biomimetic nanofiber by electrospinning of snail mucus

Background: Snail mucus (SM) is secreted by the pedal gland of snails, and has a fibrous structure when it crawls upside down on the plane. It contains biologically active compounds that have medical functions, such as glycol acid, natural antibiotics, and glycoprotein. Methods: For this paper, we prepared fibers using electrospinning to simulate this natural fiber for the first time, and we can produce the nanofiber with mucus from a snail. The effects of dissolution time and the spun solution were also investigated. Result: The results show that biomimetic nanofibers with different diameters can be obtained using electrospinning. When the concentration of the spun liquid was increased from 6wt% to 8wt%, a fiber with about a 200 nm diameter can be obtained. Adjusting the concentration plays a crucial role in electrospinning.

Biomimetic nanofibers can construct effective tissue-engineered intervertebral discs for therapeutic implantation

We developed a tissue engineered intervertebral disc (TE-IVD) based on biomimetic electrospun PCL/PLGA/Collagen nanofibers to address IVD degradation. Our study provides a novel approach for constructing TE-IVD.

Differential regulation of skin fibroblasts for their TGF-β1-dependent wound healing activities by biomimetic nanofibers

Nanofibers with different compositions differentially regulate fibroblast phenotypes in a TGF-β1 rich milieu through the integrin-mediated TGF-β1/Smad signaling pathway.