Synthesis and antibacterial properties of new monomethyl fumaric acid‐modified chitosan oligosaccharide derivatives

2022 ◽  
Author(s):  
Lingyu Zhao ◽  
Imran Mahmood Khan ◽  
Bin Wang ◽  
Lin Yue ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Fumaric Acid ◽  
Antibacterial Properties ◽  
Chitosan Oligosaccharide ◽  
Modified Chitosan

scholarly journals Facile Preparation of Tunicate-Inspired Chitosan Hydrogel Adhesive with Self-Healing and Antibacterial Properties

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4322
Author(s):  
Xiang He ◽  
Ruyue Liu ◽  
Huiqing Liu ◽  
Ruixiao Wang ◽  
Zhenhao Xi ◽  
...  
Keyword(s):  
Protein A ◽  
Gelation Time ◽  
Antibacterial Properties ◽  
Tissue Adhesive ◽  
Self Healing ◽  
Tissue Adhesion ◽  
E Coli ◽  
Modified Chitosan ◽  
Non Invasive ◽  
Chitosan Hydrogels

In order to replace traditional wound treatments such as sutures, tissue adhesives with strong wet tissue adhesion and biocompatibility have attracted more attention to the applications of non-invasive wound closure. Herein, inspired by tunicate adhesive protein, a series of 2,3,4-trihydroxybenzaldehyde (TBA)-modified chitosan hydrogels (CS-TBA-Fe) were prepared by easily mixing the solutions of chitosan-FeCl3 and TBA via the Schiff-base reaction and the coordination between Fe3+ and pyrogallol groups. The gelation time was greatly shortened to only several seconds after induced even trace Fe3+. The hydrogel (CS-TBA-Fe) exhibited ~12-fold enhanced wet tissue adhesion strength (60.3 kPa) over the commercial fibrin glue. Meanwhile, the hydrogel also showed robust adhesion to various substrates such as wood, PMMA, and aluminum. The swelling ratio and rheological property can be simply controlled by changing the concentrations of chitosan, TBA, and Fe3+. Moreover, the hydrogel displayed a rapid and highly efficient self-healing ability and an excellent antibacterial activity against E. coli. The overall results show that the CS-TBA-Fe hydrogel with enhanced wet adhesiveness will be a promising tissue adhesive material.

Preparation, characterization and antibacterial properties of 6-deoxy-6-arginine modified chitosan

2020 ◽  
Vol 230 ◽  
pp. 115635 ◽  
Author(s):  
Zhiwei Su ◽  
Qiming Han ◽  
Fang Zhang ◽  
Xianghong Meng ◽  
Bingjie Liu
Keyword(s):  
Antibacterial Properties ◽  
Modified Chitosan

scholarly journals Atmospheric Pressure Microplasma for Antibacterial Silver Nanoparticle/Chitosan Nanocomposites With Tailored Properties

2019 ◽  
Author(s):  
Daye Sun ◽  
Jonathan Turner ◽  
Nan Jiang ◽  
Songsong Zhu ◽  
Li Zhang ◽  
...  
Keyword(s):  
Silver Nanoparticle ◽  
Atmospheric Pressure ◽  
Room Temperature ◽  
Polymer Network ◽  
Antibacterial Properties ◽  
Bacterial Strains ◽  
E Coli ◽  
Modified Chitosan ◽  
First Time

<p>Room temperature atmospheric pressure microplasma (APM) was deployed for the first time for the in situ synthesis of anti-bacterial silver nanoparticle / chitosan (AgNP/CS) nanocomposites. The plasma induced liquid chemistry plays a role in the in situ formation of AgNP, the size distribution of which depends on the silver salt precursor concentration. The microplasma process has also simultaneously tailored the physical properties of the composites, rendering more crosslinked chitosan polymer network with shorter molecular chains. The formation of AgNP within the <i>in situ</i> modified chitosan has led to nanocomposites with overall improved mechanical properties and better stability in simulated body fluid. Our plasma synthesized AgNP/CS nanocomposites also demonstrate effective antibacterial properties against <i>E. Coli</i> and <i>S. Aureus</i> bacterial strains, showing their promise in potential antimicrobial applications.</p>

Molecular dynamics study on the interaction between doxorubicin and hydrophobically modified chitosan oligosaccharide

RSC Advances ◽  
2014 ◽  
Vol 4 (45) ◽  
pp. 23730-23739 ◽  
Author(s):  
Peng Shan ◽  
Jia-Wei Shen ◽  
Dong-Hang Xu ◽  
Li-Yun Shi ◽  
Jie Gao ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Hydrophobic Interactions ◽  
Chitosan Oligosaccharide ◽  
Π Interactions ◽  
Modified Chitosan ◽  
Chitosan Oligosaccharides ◽  
Hydrophobically Modified

Both π–π interactions and hydrophobic interactions were found to be essential for the loading of doxorubicin on hydrophobically modified chitosan oligosaccharides.

scholarly journals N-Halamine Hydantoin-Containing Chitosan: Synthesis, Characterization, Thermal and Photolytic Stability Studies

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3728
Author(s):  
Marta Chylińska ◽  
Halina Kaczmarek
Keyword(s):  
Antibacterial Properties ◽  
Sample Surface ◽  
Antibacterial Activities ◽  
Point Of View ◽  
Modified Chitosan ◽  
Angle Measurements ◽  
Colorimetric Test ◽  
Contact Angle Measurements ◽  
Prepared Material ◽  
Functional Features

Current demand for new protective materials ensuring sterility is systematically growing. The purpose of this work was the synthesis of the biocidal N-halamine hydantoin-containing chitosan (CS-CMH-Cl) and characterization of its properties. The functionalization of the chitosan by 5-hydantoinacetic acid substitution leads to obtaining the CS-CMH polymer, which was chlorinated in next step to transform N-H into N-Cl bonds. In this study, the possibility of forming two biocidal N-Cl bonds in hydantoin ring, grafted onto chitosan chains, was proved. The structure and stability of the prepared material was confirmed by spectroscopic (FTIR, NMR, colorimetric test) and microscopic analyses (SEM, AFM). Surface properties were investigated based on contact-angle measurements. In addition, the thermal and photochemical stability of the obtained samples were determined as functional features, determining the range of potential use. It was found that both modified chitosan polymers (CS-CMH and CS-CMH-Cl) were characterized by the smaller thermal stability and more hydrophilic and rougher surface than unmodified CS. Photooxidative degradation of the obtained materials was observed mainly on the sample surface. After irradiation, the surfaces became more hydrophilic—especially in the case of the CS-CMH-Cl—which is advantageous from the point of view of the antibacterial properties. Antibacterial tests against S. aureus and E. coli confirmed the antibacterial activities of received CS-CMH-Cl material.

A general strategy to synthesis chitosan oligosaccharide-O-Terpenol derivatives with antibacterial properties

2021 ◽  
Vol 503 ◽  
pp. 108315
Author(s):  
Lin Yue ◽  
Meihong Zheng ◽  
Min Wang ◽  
Imran Mahmood Khan ◽  
Bin Wang ◽  
...  
Keyword(s):  
Antibacterial Properties ◽  
Chitosan Oligosaccharide ◽  
General Strategy

scholarly journals Atmospheric Pressure Microplasma for Antibacterial Silver Nanoparticle/Chitosan Nanocomposites With Tailored Properties

2019 ◽  
Author(s):  
Daye Sun ◽  
Jonathan Turner ◽  
Nan Jiang ◽  
Songsong Zhu ◽  
Li Zhang ◽  
...  
Keyword(s):  
Silver Nanoparticle ◽  
Atmospheric Pressure ◽  
Room Temperature ◽  
Polymer Network ◽  
Antibacterial Properties ◽  
Bacterial Strains ◽  
E Coli ◽  
Modified Chitosan ◽  
First Time

<p>Room temperature atmospheric pressure microplasma (APM) was deployed for the first time for the in situ synthesis of anti-bacterial silver nanoparticle / chitosan (AgNP/CS) nanocomposites. The plasma induced liquid chemistry plays a role in the in situ formation of AgNP, the size distribution of which depends on the silver salt precursor concentration. The microplasma process has also simultaneously tailored the physical properties of the composites, rendering more crosslinked chitosan polymer network with shorter molecular chains. The formation of AgNP within the <i>in situ</i> modified chitosan has led to nanocomposites with overall improved mechanical properties and better stability in simulated body fluid. Our plasma synthesized AgNP/CS nanocomposites also demonstrate effective antibacterial properties against <i>E. Coli</i> and <i>S. Aureus</i> bacterial strains, showing their promise in potential antimicrobial applications.</p>

Amino Acid Dependent Performance of Modified Chitosan Against Bacteria and Red Blood Cell

2021 ◽  
Vol 21 (11) ◽  
pp. 5443-5448
Author(s):  
Xiaoyan Ju ◽  
Lu Tian ◽  
Xuantong Duan ◽  
Zhuang Li ◽  
Yongping Han ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Antibacterial Agents ◽  
Molecular Design ◽  
Antibacterial Properties ◽  
E Coli ◽  
Modified Chitosan ◽  
Charged Amino Acids ◽  
Hydrophobic Amino Acids ◽  
Positively Charged

In order to combat antibiotic resistance, the development of new antibacterial agents is essential. In this study, we prepared four types of amino acid modified chitosan (CS-AA). Compared with chitosan modified with hydrophobic amino acids, the chitosan modified with positively charged amino acids showed higher antibacterial efficiency against Escherichia coli (E. coli) under similar grafting rate. CS-AA achieves antibacterial properties mainly by destroying the integrity of bacterial cell membranes. All the four types of CS-AA show low toxicity towards red blood cells. This work indicates that positively charged groups are more important than hydrophobic groups in the design of chitosan-based antibacterial agents, and provides helpful information for the molecular design of effective antibacterial agents.

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