Comparison between single spin and double spin platelet rich plasma in pain and functional outcome of Osteoarthritis knee: A randomized controlled trial

Background: Osteoarthritis (OA) is condition characterised by progressive degeneration of joint cartilage, eventually leading to deformity of the joint. OA causes pain and disability and impacts on quality-of-life. Intra-articular platelet rich plasma gives favourable outcomes in OA knee; however, efficacy may be affected by method of preparation. Hence, this study comparing single spin and double spin platelet-rich plasma (PRP).Methods: A randomised controlled trial done among patients of OA who visited Department of Physical Medicine and Rehabilitation, Regional Institute of Medical Sciences, Imphal during August 2019-July 2021. Patients with OA knee having radiological findings of Kellgren Lawrence (KL) grade 2 and 3 (n=62) randomized into single spin PRP, (n=31) and double spin PRP, (n=31) groups and intra-articular PRP injection was given.Results: Baseline characteristics were not statistically significant. At the end of 1 week, improvement in mean difference of VAS was observe however not statistically significant (p=0.71). At end of 12 weeks and 24 weeks, there were statistically significant improvement in both mean difference of VAS (p=0.00) and WOMAC (p=0.002). Post intervention, out of the single spin PRP group, (64.51%, n=20) had complaints of adverse effects swelling, pain, redness whereas (6.45%, n=2) patients who received double spin PRP had adverse effects.Conclusions: Platelet rich plasma obtained by double spin method has long term improvement in both pain and function in patients with KL grade 2 and 3 OA knee than PRP from single spin method. Patient who received single spin PRP has more frequent post injection flare ups.

A Split Scalp Study of Single versus Double Spin Platelet-rich plasma Injections in Treatment of Female Pattern Hair Loss: Clinical Effect and Relation to Vascular Endothelial Growth Factor in PRP

Background Female pattern hair loss (FPHL) is the most common hair loss disorder in women. Platelet-rich plasma (PRP) provides an option for patients recalcitrant to the currently approved therapies. As there are many methods for the preparation of PRP, the most suitable for AGA therapy is not yet clear. Aims To compare the efficacy between single and double spin PRP injections in treatment of FPHL and to assess the relationship between the concentrations of vascular endothelial growth factor (VEGF) in the PRP preparation and the treatment results obtained. Patients and Methods 15 female patients with FPHL were enrolled. Each patient was subjected to intradermal injection of PRP (prepared by double-spin method) into the right half of the scalp, in addition to intradermal injection of PRP (prepared by singlespin method) into the left half of the scalp in the form of three treatment sessions three weeks apart. Evaluation of treatment response was done through comparing patients' global photographs, assessment of patients' satisfaction and folliscopic assessment before and after treatment. Results Our results showed clinically significant improvement by comparing patients' photographs in most of the treated patients. In addition, folliscopy revealed significant change of the terminal hair density in the right half of the scalp following treatment sessions.VEGF concentration didn't differ significantly between double-spin and single-spin prepared PRP, also it didn't differ significantly upon calcium activation. Conclusions PRP is an effective treatment modality for FPHL. Double-spin prepared PRP could yield better results in the treatment of FPHL than the single-spin method. However, adding Calcium gluconate prior to PRP injection is of no benefit as it didn't significantly increase the release of VEGF. Yet, further studies discussing different PRP preparation protocols and involving a larger number of cases are needed to minimize statistical errors and to detect the most accurate PRP preparation method with the greatest yield of growth factors.

Design and simulation research of the double-spin folding mechanism based on a suspended missile

Based on the suspension of a missile using folding rotary wings and airbags, in order to improve the basic parameters and motion characteristics of the rotor during the unfolding process and analyze the aerodynamic characteristics of the entire device in the suspension state, after proposing a scheme of double-spin mechanism, the main folding and unfolding mechanism, initial driving device, rotating driving device, and locking mechanism were designed, and the simulation research is studied by the Automatic Dynamic Analysis of Mechanical System and Ansys Fluent Fluid Simulation software, respectively. The results show that the rotation rate was controlled at 41.8 mm/s, the various motion parameters are reasonable, and the operation process is relatively smooth, with high reliability. The speed and pressure value at the tip of the rotor are higher and the aerodynamic disturbance is obvious, which has a great influence on the aerodynamic performance. The speed and pressure distribution of the surrounding flow field is stable, the lift provided is 46 N, and the lift coefficient is 0.55, which can ensure the long-time suspension state of the missile. This paper puts forward a valuable design idea and has practical reference value for the research of the suspended missile.

Comparison of efficacy of topical 5% minoxidil alone versus topical 5% minoxidil with autologous Platelet Rich Plasma (PRP) therapy in treatment of androgenetic alopecia: A randomised open label study

Androgenic alopecia (AGA) is a type of progressive hairloss, where there is androgen mediated conversion of susceptible terminal hairs into vellus hairs, in genetically predisposed individuals. To compare efficacy of Topical 5% Minoxidil alone versus Topical 5% Minoxidil with Autologous Platelet Rich Plasma (PRP) therapy in patients with Androgenetic Alopecia.This is aProspective study conducted in Department of Dermatology GMERS Medical College, Gandhinagar, Gujarat. A convenience sample of 62 men in the age group of 20-40 with Grade 2-5 AGA according to Hamilton- Norwood Grading were selected and was divided into 2 groups of 31 each. Presitting digital photographs and dermoscopic photos were taken. Autologous PRP was prepared using 18 ml of patients blood after double spin centrifugation and injected by Nappage technique. Results were assessed at the baseline and at the end of each sitting on the basis of change in hair density, photographic evaluation and patient’s self satisfaction. Highly significant increase in hair density was achieved after 4 months of treatment. At T4 (Fourth Session of treatment) Group B showed higher hair density (42.97± 8.96) as compared to Group A (36.94 ± 11.57) which was statistically significant at P = 0.03Group B showed better improvement as compared to Group A.PRP treatment has a positive therapeutic effect on male Androgenetic alopecia without major side effects.