7sl rna
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2018 ◽  
Vol 90 (12) ◽  
pp. 1822-1826
Author(s):  
Burcu Bayyurt ◽  
Serdal Arslan ◽  
Aynur Engin ◽  
Mehmet Bakir

RNA ◽  
2018 ◽  
Vol 24 (7) ◽  
pp. 908-914 ◽  
Author(s):  
Gaëlle J.S. Talhouarne ◽  
Joseph G. Gall
Keyword(s):  

Traffic ◽  
2017 ◽  
Vol 19 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Michelle S. Itano ◽  
Helene Arnion ◽  
Sandra L. Wolin ◽  
Sanford M. Simon
Keyword(s):  
7Sl Rna ◽  

2014 ◽  
Vol 42 (15) ◽  
pp. 10099-10111 ◽  
Author(s):  
Kotb Abdelmohsen ◽  
Amaresh C Panda ◽  
Min-Ju Kang ◽  
Rong Guo ◽  
Jiyoung Kim ◽  
...  

Abstract Noncoding RNAs (ncRNAs) and RNA-binding proteins are potent post-transcriptional regulators of gene expression. The ncRNA 7SL is upregulated in cancer cells, but its impact upon the phenotype of cancer cells is unknown. Here, we present evidence that 7SL forms a partial hybrid with the 3′-untranslated region (UTR) of TP53 mRNA, which encodes the tumor suppressor p53. The interaction of 7SL with TP53 mRNA reduced p53 translation, as determined by analyzing p53 expression levels, nascent p53 translation and TP53 mRNA association with polysomes. Silencing 7SL led to increased binding of HuR to TP53 mRNA, an interaction that led to the promotion of p53 translation and increased p53 abundance. We propose that the competition between 7SL and HuR for binding to TP53 3′UTR contributes to determining the magnitude of p53 translation, in turn affecting p53 levels and the growth-suppressive function of p53. Our findings suggest that targeting 7SL may be effective in the treatment of cancers with reduced p53 levels.


Acta Naturae ◽  
2013 ◽  
Vol 5 (4) ◽  
pp. 83-93 ◽  
Author(s):  
D. N. Baryakin ◽  
D. V. Semenov ◽  
A. V. Savelуeva ◽  
O. A. Koval ◽  
I. V. Rabinov ◽  
...  

11% of the human genome is composed of Alu-retrotransposons, whose transcription by RNA polymerase III (Pol III) leads to the accumulation of several hundreds to thousands of Alu-RNA copies in the cytoplasm. Expression of Alu-RNA Pol III is significantly increased at various levels of stress, and the increase in the Alu-RNA level is accompanied by a suppression of proliferation, a decrease in viability, and induction of apoptotic processes in human cells. However, the question about the biological functions of Pol III Alu-transcripts, as well as their mechanism of action, remains open. In this work, analogues of Alu-RNA and its evolutionary ancestor, 7SL RNA, were synthesized. Transfection of human breast adenocarcinoma MCF-7 cells with the Alu-RNA and 7SL RNA analogues is accompanied by a decrease in viability and by induction of proapoptotic changes in these cells. The analysis of the combined action of these analogues and actinomycin D or tamoxifen revealed that the decreased viability of MCF-7 cells transfected with Alu-RNA and 7SL RNA was due to the modulation of transcription. A whole transcriptome analysis of gene expression revealed that increased gene expression of the transcription regulator NUPR1 (p8), as well as the transcription factor DDIT3 (CHOP), occurs under the action of both the Alu- and 7SL RNA analogues on MCF-7 cells. It has been concluded that induction of proapoptotic changes in human cells under the influence of the Alu-RNA and 7SL RNA analogues is related to the transcriptional activation of the genes of cellular stress factors, including the endoplasmic reticulum stress response factors.


PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e40705 ◽  
Author(s):  
Yong-Feng Ren ◽  
Guiling Li ◽  
Jianmin Wu ◽  
Yong-Feng Xue ◽  
Yi-Jiang Song ◽  
...  
Keyword(s):  

2012 ◽  
Vol 86 (15) ◽  
pp. 7934-7942 ◽  
Author(s):  
S. E. Keene ◽  
A. Telesnitsky
Keyword(s):  
7Sl Rna ◽  

2012 ◽  
Vol 57 (2) ◽  
Author(s):  
Wang Guan ◽  
De-Ping Cao ◽  
Ke sun ◽  
Jia-nan Xu ◽  
Jun-rong Zhang ◽  
...  

AbstractThe leishmaniases are zoonotic diseases caused by protozoan parasites of the genus Leishmania. Leishmaniases are still endemic in China, especially in the west and northwest froniter regions. To revalue the preliminary phylogenetic results of Chinese Leishmania isolates, we amplified partial fragment of small subunit ribosomal RNA (SSU rRNA) and 7 spliced leader RNA (7SL RNA), then tested the phylogenetic relationships among Chinese Leishmania isolates and their relatives by analyzing SSU rRNA gene sequences and 7SL RNA gene sequences. 19 SSU RNA sequences and 9 7SL RNA sequences were obtained in our study, then analyzed with 42 SSU RNA sequences and 32 7SL RNA sequences retrieved from Genbank, respectively. In the Bayesian analysis of the SSU RNA gene, the isolate MHOM/CN/93/GS7 and the isolate IPHL/CN/77/XJ771 are members of Leishmania donovani complex, while the isolate MHOM/CN/84/JS1 clustered with Leishmania tropica. The other 11 Chinese Leishmania isolates (MHOM/CN/90/WC, MCAN/CN/90/SC11, MHOM/CN/80/XJ801, MHOM/CN/85/GS4, MHOM/CN/84/SD1, MCAN/CN/86/SC7, MHOM/CN/54/#3, MHOM/CN/83/GS2, MHOM/CN/90/SC10H2, MHOM/CN/89/GS6 and MHOM/CN/ 89/GS5) form an unclassified group, defined as Leishmania sp., and the most relative species to this group is L. tarentolae. In the Bayesian analysis of the 7SL RNA gene, 9 Chinese Leishmania isolates also formed an unclassified group with L. tarentolae, including canine isolate 10, MHOM/CN/85/GS4, MHOM/CN/84/SD1, MCAN/CN/86/SC7, MHOM/CN/54/#3, MHOM/ CN/83/GS2, MHOM/CN/90/SC10H2, MHOM/CN/89/GS6 and MHOM/CN/89/GS5. We concluded that: (1) Chinese Leishmania isolates are non-monophyly group; (2) an unclassified group may exist in China, and the most relative species to this group is L. tarentolae; (3) MHOM/CN/84/JS1, which was previously assigned as L. donovani, was most genetically related to L. tropica strain MHOM/SU/74/K27.


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