How Wide Is the Window Opened by High-Resolution Relaxometry on the Internal Dynamics of Proteins in Solution?

Here we apply the detectors approach to probe the amount of information in high-resolution relaxometry measurements in biological macromolecules in solution. We show that high-resolution relaxometry provides new relevant information in the nanosecond range and that the additional range of information is all the more large as the overall rotational diffusion is slow.

Исследование пространственной динамики включения лазера-тиристора (905 нм) на основе многопереходной гетероструктуры AlGaAs/InGaAs/GaAs

The switching on process spatial dynamics of a laser-thyristor based on an AlGaAs/InGaAs/GaAs heterostructure with a thin p-base has been studied. The heterostructure had a modified base with a middle-doped layer at the n-emitter, which makes it possible to increase the operating voltages in order to generate nanosecond current pulses. In laser thyristor pulsed sources based on the proposed heterostructure, a high degree of current flow region localization arising during turn on process of the device was demonstrated. Using the current localization regions luminescence, the propagation dynamics of the switched-on state was estimated. The anode contact sizes required for the nanosecond range pulsed current switches or laser emitters development are obtained.

How Wide Is the Window Opened by High-Resolution Relaxometry on the Internal Dynamics of Proteins in Solution?

Here we apply the detectors approach to probe the amount of information in high-resolution relaxometry measurements in biological macromolecules in solution. We show that high-resolution relaxometry provides new relevant information in the nanosecond range and that the additional range of information is all the more large as the overall rotational diffusion is slow.

How Wide Is the Window Opened by High-Resolution Relaxometry on the Internal Dynamics of Proteins in Solution?

Here we apply the detectors approach to probe the amount of information in high-resolution relaxometry measurements in biological macromolecules in solution. We show that high-resolution relaxometry provides new relevant information in the nanosecond range and that the additional range of information is all the more large as the overall rotational diffusion is slow.

Solid cyclooctatetraene-based triplet quencher demonstrating excellent suppression of singlet–triplet annihilation in optical and electrical excitation

Triplet excitons have been identified as the major obstacle to the realisation of organic laser diodes, as accumulation of triplet excitons leads to significant losses under continuous wave (CW) operation and/or electrical excitation. Here, we report the design and synthesis of a solid-state organic triplet quencher, as well as in-depth studies of its dispersion into a solution processable bis-stilbene-based laser dye. By blending the laser dye with 20 wt% of the quencher, negligible effects on the ASE thresholds, but a complete suppression of singlet–triplet annihilation (STA) and a 20-fold increase in excited-state photostability of the laser dye under CW excitation, were achieved. We used small-area OLEDs (0.2 mm2) to demonstrate efficient STA suppression by the quencher in the nanosecond range, supported by simulations to provide insights into the observed STA quenching under electrical excitation. The results demonstrate excellent triplet quenching ability under both optical and electrical excitations in the nanosecond range, coupled with excellent solution processability.

Electrochemotherapy Using Doxorubicin and Nanosecond Electric Field Pulses: A Pilot in Vivo Study

Pulsed electric field (PEF) is frequently used for intertumoral drug delivery resulting in a well-known anticancer treatment—electrochemotherapy. However, electrochemotherapy is associated with microsecond range of electrical pulses, while nanosecond range electrochemotherapy is almost non-existent. In this work, we analyzed the feasibility of nanosecond range pulse bursts for successful doxorubicin-based electrochemotherapy in vivo. The conventional microsecond (1.4 kV/cm × 100 µs × 8) procedure was compared to the nanosecond (3.5 kV/cm × 800 ns × 250) non-thermal PEF-based treatment. As a model, Sp2/0 tumors were developed. Additionally, basic current and voltage measurements were performed to detect the characteristic conductivity-dependent patterns and to serve as an indicator of successful tumor permeabilization both in the nano and microsecond pulse range. It was shown that nano-electrochemotherapy can be the logical evolution of the currently established European Standard Operating Procedures for Electrochemotherapy (ESOPE) protocols, offering better energy control and equivalent treatment efficacy.