Anatomy of the lumbar interspinous ligament: findings relevant to epidural insertion using loss of resistance

Background and objectivesThe ‘loss of resistance’ technique is used to determine entry into the epidural space, often by a midline needle in the interspinous ligament before the ligamentum flavum. Anatomical explanations for loss of resistance without entry into the epidural space are lacking. This investigation aimed to improve morphometric characterization of the lumbar interspinous ligament by observation and measurement at dissection and from MRI.MethodsMeasurements were made on 14 embalmed donor lumbar spines (T12 to S1) imaged with MRI and then dissected along a tilted axial plane aligned with the lumbar interspace.ResultsIn 73 interspaces, median (IQR) lumbar interspinous plus supraspinous ligament length was 29.7 mm (25.5–33.4). Posterior width was 9.2 mm (7.7, 11.9), with narrowing in the middle (4.5 mm (3.0, 6.8)) and an anterior width of 7.3 mm (5.7, 9.8).Fat-filled gaps were present within 55 (75%). Of 51 anterior gaps, 49 (67%) were related to the ligamenta flava junction. Median (IQR) gap length and width were 3.5 mm (2.5, 5.1) and 1.1 mm (0.9, 1.7).Detection of gaps with MRI had 100% sensitivity (95% CI 93.5 to 100), 94.4% specificity (72.7, 99.9), 98.2% (90.4, 100) positive predictive value and 100% (80.5, 100) negative predictive value against dissection as the gold standard.ConclusionsThe lumbar interspinous ligament plus supraspinous ligament are biconcave axially. It commonly has fat-filled gaps, particularly anteriorly. These anatomical features may form the anatomical basis for false or equivocal loss of resistance.

Axially Loaded Magnetic Resonance Imaging Identification of the Factors Associated with Low Back-Related Leg Pain

This retrospective observational study was conducted to identify factors associated with low back-related leg pain (LBLP) using axially loaded magnetic resonance imaging (AL-MRI). Ninety patients with low back pain (LBP) underwent AL-MRI of the lumbar spine. A visual analog scale and patient pain drawings were used to evaluate pain intensity and location and determine LBLP cases. The values of AL-MRI findings were analyzed using a logistic regression model with a binary dependent variable equal to one for low back-related leg pain and zero otherwise. Logistic regression results suggested that intervertebral joint effusion (odds ratio (OR) = 4.58; p = 0.035), atypical ligamenta flava (OR = 5.77; p = 0.003), and edema of the lumbar intervertebral joint (OR = 6.41; p = 0.003) were more likely to be present in LBLP patients. Advanced disc degeneration (p = 0.009) and synovial cysts (p = 0.004) were less frequently observed in LBLP cases. According to the AL-MRI examinations, the odds of having LBLP are more likely if facet effusion, abnormal ligamenta flava, and lumbar facet joint edema are present on imaging than if not. The assessment of lumbar spine morphology in axial loaded MRI adds value to the potential understanding of LBLP, but further longitudinal and loaded–unloaded comparative studies are required to determine the role of acute dynamic changes and instability in LBLP development.

Spinal cord lesion and ischemic stroke after chiropractic: a case report

Context: Chiropractic is a form of spinal manipulation used to treat cervical pain. This therapy is considered safer than chronic use of anti-inflammatory drugs, opioids or spine surgery. However, chiropractic may cause severe complications such as myelopathy and ischemic stroke. Case report: A 48-year-old woman was admitted to our hospital due to acute tetraparesis. During a chiropractic session for chronic neck pain, patient referred lancinating cervical pain, weakness in the upper and lower limbs, and numbness below the level of the neck. Neurologic examination showed grade two tetraparesis with preserved arm abduction. Pain and vibratory sensation were reduced in trunk, upper and lower limbs. We considered a C5 level spinal cord injury. Cervical spine magnetic resonance imaging revealed a transdiscal fracture of C5-C6 vertebrae. The fracture led to an epidural hematoma and spinal cord compression. Cervical spine displayed ligamenta flava thickening, which may be associated with an undiagnosed ankylosing spondylitis. We also found bilateral vertebral occlusion of V1 and V2 segments. Cerebellar restricted diffusion suggested posterior circulation stroke. We believe that rigidity associated with ankylosing spondylitis favored spinal fracture during chiropractic. Patient was treated with 24mg/day of dexamethasone and 100mg/day of aspirin. Spinal cord decompression surgery was indicated. Unfortunately, in the last followup there was no improvement in patient motor status. Conclusions: Transdiscal C5-C6 fracture led to compressive myelopathy and cerebellar stroke. Safety of chiropractic should be better investigated in specific populations such as ankylosing spondylitis patients.

Model of Pathological Collagen Mineralization Based on Spine Ligament Calcification

The aim of the study was to determine the time of mineral growth in human spine ligaments using a mathematical model. The study was based on our previous research in which the physicochemical analysis and computed microtomography measurements of deposits in ligamenta flava were performed. Hydroxyapatite-like mineral (HAP) constituted the mineral phase in ligament samples, in two samples calcium pyrophosphate dehydrate (CPPD) was confirmed. The micro-damage of collagen fibrils in the soft tissue is the crystallization center. The growth of the mineral nucleus is a result of the calcium ions deposition on the nucleus surface. Considering the calcium ions, the main component of HAP, it is possible to describe the grain growth using a diffusion model. The model calculations showed that the growth time of CPPD grains was ca. a month to 6 years, and for HAP grains >4 years for the young and >5.5 years for the elderly patients. The growth time of minerals with a radius >400 μm was relatively short and impossible to identify by medical imaging techniques. The change of growth rate was the largest for HAP deposits. The mineral growth time can provide valuable information for understanding the calcification mechanism, may be helpful in future experiments, as well as useful in estimating the time of calcification appearance.

Effect of Active Head Restraint on Cervical Vertebrae Injuries Lessening

A three-dimensional multi-body model of the 50th percentile male human and discretized neck was built to evaluate the effect of active head restraint on cervical vertebrae injuries lessening in vehicle rear impact. The discretized neck includes of cervical spine vertebrae, intervertebral discs, ligaments, and muscles. The BioRID-II adult male dummy restrained using safety belt was seated on a sled, whose longitudinal velocity measured from rear impact FEM simulation was applied to simulate the relative motion of the head and neck. According to the interspinous ligament loads and the ligamenta flava loads of the cervical spine, an active head restraint and an impact absorber were designed to lessening the neck injuries in vehicle rear end collisions.