Quality of diabetes care in patients with schizophrenia: a case-control study in Qatar

Background Patients with schizophrenia are at least twice as likely to develop diabetes mellitus compared to the general population. This is of significance in Qatar given the high prevalence of obesity and diabetes. Furthermore, the lifespan of people with schizophrenia is shortened by approximately 15 years, partly due to long-term microvascular and macrovascular complications. High quality diabetes care can significantly reduce morbidity and mortality. We assessed the level of diabetes care delivered to patients in Qatar with schizophrenia and diabetes compared to those with diabetes alone. Methods We performed a retrospective chart review of patients with diabetes mellitus with (n = 73) and without (n = 73) schizophrenia. Demographic information and electronic medical records were reviewed to determine adherence to American Diabetes Association standards of diabetes care in the last 6 and 12 months. Optimal diabetes care was defined as having completed glycated hemoglobin (HbA1c), lipid profile and retinal examination within 12 months. Results Optimal diabetes care was significantly lower in patients with schizophrenia and diabetes compared to diabetes alone [26.0% (n = 19/73) vs 52.1% (n = 38/73), p = 0.002]. Patients with diabetes and schizophrenia were also significantly less likely to have had body mass index recorded within 6 months (p = 0.008) and HbA1c (p = 0.006), lipid profile (p = 0.015), estimated glomerular filtration rate (eGFR) (p = 0.001) and order for retinal examination (p = 0.004) over 12 months. After adjusting for multiple comparisons, only assessment of eGFR (p = 0.01) and order for retinal examination (p = 0.04) remained significant. Conclusion Patients in Qatar with schizophrenia and diabetes, receive sub-optimal diabetes care compared to those with diabetes alone.

Risk of Metabolic Syndrome in Kidney Stone Formers: A Comparative Cohort Study with a Median Follow-Up of 19 Years

Background: Kidney stone formers (SF) are more likely to develop diabetes mellitus (DM), but there is no study examining risk of metabolic syndrome (MetS) in this population. We aimed to describe the risk of MetS in SF compared to non-SF. Methods and Materials: SF referred to a tertiary referral metabolic centre in Southern England from 1990 to 2007, comparator patients were age, sex, and period (first stone) matched with 3:1 ratio from the same primary care database. SF with no documentation or previous MetS were excluded. Ethical approval was obtained and MetS was defined using the modified Association of American Clinical Endocrinologists (AACE) criteria. Analysis with cox proportional hazard regression. Results: In total, 828 SF were included after 1000 records were screened for inclusion, with 2484 age and sex matched non-SF comparators. Median follow-up was 19 years (interquartile range—IQR: 15–22) for both stone formers and stone-free comparators. SF were at significantly increased risk of developing MetS (hazard ratio—HR: 1.77; 95% confidence interval—CI: 1.55–2.03, p < 0.001). This effect was robust to adjustment for pre-existing components (HR: 1.91; 95% CI: 1.66–2.19, p < 0.001). Conclusions: Kidney stone formers are at increased risk of developing metabolic syndrome. Given the pathophysiological mechanism, the stone is likely a ‘symptom’ of an underlying metabolic abnormality, whether covert or overt. This has implications the risk of further stone events and cardiovascular disease.

Quality of Diabetes Care in Patients with Schizophrenia: A Case-Control Study.

BackgroundPatients with schizophrenia are at least twice as likely to develop diabetes mellitus compared to the general population. This is of significance in Qatar given the high prevalence of obesity and diabetes. Furthermore, the lifespan of people with schizophrenia and diabetes is shortened by approximately15 years due to long-term microvascular and macrovascular complications. High quality diabetes care can significantly reduce morbidity and mortality. We assessed the level of diabetes care delivered to patients with schizophrenia and diabetes compared to those with diabetes alone.MethodsWe performed a retrospective chart review of patients with diabetes mellitus with (n=73) and without (n=73) schizophrenia. Demographic information and electronic medical records were reviewed for 6-month and 1-year American Diabetic Association standards of diabetes care. Optimal diabetes care was defined as having completed glycated hemoglobin (HbA1c), lipid profile and retinal examination within 12 months. ResultsOptimal diabetes care was significantly lower in patients with schizophrenia and diabetes compared to diabetes alone [26.0% (n=19/73) vs 52.1% (n=38/73), p=0.002]. Patients with diabetes and schizophrenia were also significantly less likely to have had body mass index recorded within six months (p=0.008) and HbA1c (p=0.006), lipid profile (p=0.015), estimated glomerular filtration rate (eGFR) (p=0.001) and order for retinal screening (p=0.004) over 12 months. After adjusting for multiple comparisons, only assessment of eGFR (p=0.01) and order for retinal screening (p=0.04) remained significant. ConclusionPatients with schizophrenia and diabetes in Qatar receive sub-optimal diabetes care compared to those with diabetes alone.

KORELASI KADAR KOLESTEROL DENGAN KEJADIAN DIABETES MELLITUS TIPE 2 PADA LAKI-LAKI

Type 2 diabetes is one of the most common chronic diseases in the world. It is estimated thatmore than 140 million people worldwide are currently suffering from diabetes, and by 2025, anestimated more than 300 million people will suffer from the disease. The purpose of this study was toevaluate the correlation of cholesterol with the incidence of Diabetes Mellitus disease. The type of thisresearch is observational with cross-sectional analytic approach and done in PLN employees, total are112 people of which are mens. All participants underwent biochemical analysis of fasting blood sugar(BSN) and 2 hours PP (post prandial), and total cholesterol level test. Determination of glucose byglucose oxidase method and cholesterol level by CHOD-PAP method. The mean results in normalcholesterol (< 200 mg/dl) obtained BSN = 73 mg / dl, 2 Hours PP = 92 mg / dl, and in abnormalcholesterol (> 200 mg/dl) mean BSN = 81 mg / dl, 2 hours PP = 109 mg / dl, in independent T test withp = 0001 in both groups of different cholesterol levels. Results of the Pearson's correlation test, therewas a significant positive correlation between GDP and cholesterol levels (r = 0.262, p = 0.005), and 2hours PP and cholesterol levels (r = 0.258, p = 0.006). Conclusions: There was a significant positivecorrelation between 2 hours PP and cholesterol levels. This study shows there is a correlation ofcholesterol levels that develop diabetes mellitus type 2.

Faktor individu dalam prediksi diabetes mellitus tipe 2 di Salatiga Jawa Tengah

Individual factors as predictors of diabetes mellitus in SalatigaPurposeThe purpose of this study was to determine the relationship of the individual factors with the incidence of diabetes mellitus in Salatiga.MethodsThe research was a case control study conducted from April to June 2016 around the existing health centers in the Salatiga. The total sample was 156 respondents. Data analysis used McNemar’s Chi-square and multiple logistic regression conditional tests.ResultsThe variables associated with the incidence of diabetes mellitus was a family history of diabetes. People who have a family history of diabetes have a risk 41 times more likely to develop diabetes mellitus compared with people who do not have a family history of diabetes mellitus in Salatiga.ConclusionThis study concluded that the incidence of diabetes mellitus is affected by family history. Primary health care is expected to cooperate with health office to conduct prevention efforts such as activities that encourage physical activity.

A Rare Case of Complete Agenesis of Dorsal Pancreas

ABSTRACT Agenesis of dorsal pancreas (ADP) is an extremely rare congenital anomaly that results from defective development of pancreas. Most ADP patients are asymptomatic; if symptomatic, they present with epigastric pain. About half of affected individuals develop diabetes mellitus (DM), resulting from reduced islet cell mass secondary to the absence of endocrine structures. Being very rare, it is generally not kept in mind while dealing these cases and are not suspected until imaging investigations are not done. In our case study, ADP was diagnosed during evaluation of the patient for recurrent pain abdomen and generalized weakness. How to cite this article Jain A, Singh M, Dey S, Kaura A, Diwakar G. A Rare Case of Complete Agenesis of Dorsal Pancreas. Euroasian J Hepato-Gastroenterol 2017;7(2):183-184.