Effect of Peak Tracking Methods on FBG Calibration Derived by Factorial Design of Experiment

We present a calibration procedure for a humidity sensor made of a fiber Bragg grating covered by a polyimide layer. FBGs being intrinsically sensitive to temperature and strain, the calibration should tackle three variables, and, therefore, consists of a three-variable, two-level factorial design tailored to assess the three main sensitivities, as well as the five cross-sensitivities. FBG sensing information is encoded in the reflection spectrum from which the Bragg wavelength should be extracted. We tested six classical peak tracking methods on the results of the factorial design of the experiment applied to a homemade FBG humidity sensor. We used Python programming to compute, from the raw spectral data with six typical peak search algorithms, the temperature, strain and humidity sensitivities, as well as the cross-sensitivities, and showed that results are consistent for all algorithms, provided that the points selected to make the computation are correctly chosen. The best results for this particular sensor are obtained with a 3 dB threshold, whatever the peak search method used, and allow to compute the effective humidity sensitivity taking into account the combined effect of temperature and strain. The calibration procedure presented here is nevertheless generic and can thus be adapted to other sensors.

Microscale dynamics of electrophysiological markers of epilepsy

ObjectiveInterictal discharges (IIDs) and high frequency oscillations (HFOs) are neurophysiologic biomarkers of epilepsy. In this study, we use custom poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) microelectrodes to better understand their microscale dynamics.MethodsElectrodes with spatial resolution down to 50µm were used to record intraoperatively in 30 subjects. For IIDs, putative spatiotemporal paths were generated by peak-tracking, followed by clustering. For HFOs, repeating patterns were elucidated by clustering similar time windows. Fast events, consistent with multi-unit activity (MUA), were covaried with either IIDs or HFOs.ResultsIIDs seen across the entire array were detected in 93% of subjects. Local IIDs, observed across <50% of the array, were seen in 53% of subjects. IIDs appeared to travel across the array in specific paths, and HFOs appeared in similar repeated spatial patterns. Finally, microseizure events were identified spanning 50-100µm. HFOs covaried with MUA, but not with IIDs.ConclusionsOverall, these data suggest micro-domains of irritable cortex that form part of an underlying pathologic architecture that contributes to the seizure network.SignificanceMicroelectrodes in cases of human epilepsy can reveal dynamics that are not seen by conventional electrocorticography and point to new possibilities for their use in the diagnosis and treatment of epilepsy.HighlightsPEDOT:PSS microelectrodes with at least 50µm spatial resolution uniquely reveal spatiotemporal patterns of markers of epilepsyHigh spatiotemporal resolution allows interictal discharges to be tracked and reveal cortical domains involved in microseizuresHigh frequency oscillations detected by microelectrodes demonstrate localized clustering on the cortical surface

Towards an Ultra Sensitive Hybrid Mass Sensor Based on Mode Localization without Resonance Tracking

We present a mode localized mass sensor prototype based on a hybrid system excited at a fixed frequency slightly below the resonances. Indeed, we show, both theoretically and experimentally, that this condition yields higher sensitivities and similar sensitivity ranges than that of resonance peak tracking while being less time consuming than a classical open-loop configuration due to the absence of frequency sweep. The system is made of a quartz resonator and a hardware that includes a resonator and the coupling. The digital aspect allows maximum sensitivity to be achieved with a fine tuning of the different parameters and the implementation of a coupling, regardless of the physical resonator geometry. This allows the generation of mode localization on shear waves resonant structures such as the quartz cristal microbalance widely used in biosensing. This solution has been successfully implemented using resin micro balls depositions. The sensitivities reach almost their maximum theoretical values which means this fixed frequency method has the potential to reach lower limit of detection than the open loop frequency tracking method.