Genetic Distribution of Five Spinocerebellar Ataxia Microsatellite Loci in Mexican Native American Populations and Its Impact on Contemporary Mestizo Populations

Spinocerebellar ataxias (SCAs) conform a heterogeneous group of neurodegenerative disorders with autosomal dominant inheritance. Five of the most frequent SCAs are caused by a CAG repeat expansion in the exons of specific genes. The SCAs incidence and the distribution of polymorphic CAG alleles vary among populations and ethnicities. Thus, characterization of the genetic architecture of ethnically diverse populations, which have undergone recent admixture and demographic events, could facilitate the identification of genetic risk factors. Owing to the great ethnic diversity of the Mexican population, this study aimed to analyze the allele frequencies of five SCA microsatellite loci (SCA1, SCA2, SCA3, SCA6, and SCA7) in eleven Mexican Native American (MNA) populations. Data from the literature were used to compare the allelic distribution of SCA loci with worldwide populations. The SCA loci allelic frequencies evidenced a certain genetic homogeneity in the MNA populations, except for Mayans, who exhibited distinctive genetic profiles. Neither pathological nor large normal alleles were found in MNA populations, except for the SCA2 pre-mutated allele in the Zapotec population. Collectively, our findings demonstrated the contribution of the MNA ancestry in shaping the genetic structure of contemporary Mexican Mestizo populations. Our results also suggest that Native American ancestry has no impact on the origin of SCAs in the Mexican population. Instead, the acquisition of pathological SCA alleles could be associated with European migration.

What's in a Name?

The topic of tax behavior always stirs attention among scholars, professionals, national and international authorities, organizations, and citizens alike since it is a complex matter. There are four types of tax behavior acknowledged in the literature, namely voluntary tax compliance, enforced tax compliance, tax avoidance, tax evasion. The complexity of tax behavior stems from the fact that there are a manifold of factors influencing it, from economic to psychological ones. The chapter surveys relevant sources on tax behavior in the quest for eliciting the impact of ethnic diversity on tax compliance. At the same time, the difference between countries are also addressed.

PENERAPAN MEDIA PEMBELAJARAN MELALUI MEDIA DISPLAY UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA MATA PELAJARAN PPKN KEANEKARAGAMAN SUKU BANGSA KELAS 4 DI SEKOLAH DASAR

Learning media is a tool that is used as a support for the implementation of learning to learn to learn to learn, ranging from book sources to other media, and researchers also provide learning media in the form of display board media to 4th grade students in SDN Panunggulan 2 as a learning media tool so that learning can run effectively. The display media itself is a medium that can be used to display images such as posters, and other small objects that are three-dimensional with this also as a support for student learning so that students can be used in learning and also seen directly by students. Therefore, researchers provided a media display in the form of this image to the 4th class on the material of ethnic diversity in Indonesia because in the material is still low learning results about VAT material diversity of ethnic groups in Indonesia and.the use of this media aims to help teachers and students in improving learning outcomes. Learning outcomes are changes in students including their behavior in real terms that are done through the teaching and learning process that is in accordance with the learning objectives and with the learning outcomes teachers are able to see the development that has been owned by the student.

Cultural Diversity and Performance of Cameroonian Companies

The objective of this study is to highlight the effects of ethnic, linguistic, and religious diversity on business sustainability in Cameroon. To achieve this objective, the authors used data from a survey conducted in the cities of Douala and Yaoundé by the Laboratory for Research in Fundamental and Applied Economics (LAREFA) of the University of Dschang. Using a censored Tobit model, the following results were obtained: (1) Ethnic diversity and linguistic diversity each have a positive effect on the sustainability of Cameroonian companies. However, when the linguistic diversity index is too high, its effect becomes significantly negative. (2) Whatever its level, religious diversity has a negative effect on the sustainability of Cameroonian companies.