tetraspanin 7
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Author(s):  
Minhee Kim ◽  
Jingjing Lin ◽  
Jeong‐Eun Huh ◽  
Jin Hee Park ◽  
Miyeon Go ◽  
...  

2020 ◽  
Vol 598 (21) ◽  
pp. 4887-4905 ◽  
Author(s):  
Matthew T. Dickerson ◽  
Prasanna K. Dadi ◽  
Regan B. Butterworth ◽  
Arya Y. Nakhe ◽  
Sarah M. Graff ◽  
...  

2020 ◽  
Vol 209 (4) ◽  
pp. 437-445 ◽  
Author(s):  
Kerry A. McLaughlin ◽  
Melissa A. Tombs ◽  
Michael R. Christie

Diabetologia ◽  
2019 ◽  
Vol 62 (5) ◽  
pp. 805-810 ◽  
Author(s):  
Anne Eugster ◽  
Gloria Kraus ◽  
Vicky Lidzba ◽  
Denise Müller ◽  
Manja Jolink ◽  
...  

Diabetologia ◽  
2018 ◽  
Vol 62 (3) ◽  
pp. 399-407 ◽  
Author(s):  
Xiajie Shi ◽  
Gan Huang ◽  
Yanfei Wang ◽  
Zhenqi Liu ◽  
Chao Deng ◽  
...  

2017 ◽  
Vol 45 (3) ◽  
pp. 703-708 ◽  
Author(s):  
Mickaël M. Ménager

Dendritic cells (DCs) have essential roles in early detection of pathogens and activation of both innate and adaptive immune responses. Whereas human DCs are resistant to productive HIV-1 replication, they have a unique ability to take up virus and transmit it efficiently to T lymphocytes. By doing that, HIV-1 may evade, at least in part, the first line of defense of the immune system, exploiting DCs instead to facilitate rapid infection of a large pool of immune cells. While performing an shRNA screen in human primary monocyte-derived DCs, to gain insights into this cell biological process, we discovered the role played by tetraspanin-7 (TSPAN7). This member of the tetraspanin family appears to be a positive regulator of actin nucleation and stabilization, through the ARP2/3 complex. By doing so, TSPAN7 limits HIV-1 endocytosis and maintains viral particles on actin-rich dendrites for an efficient transfer toward T lymphocytes. While studying the function of TSPAN7 in the control of actin nucleation, we also discovered the existence in DCs of two opposing forces at the plasma membrane: actin nucleation, a protrusive force which seems to counterbalance actomyosin contraction.


2017 ◽  
Vol 31 (6) ◽  
pp. 2301-2313 ◽  
Author(s):  
Seol‐Ae Lee ◽  
Yeongjun Suh ◽  
Saebom Lee ◽  
Jaehoon Jeong ◽  
Soo Jeong Kim ◽  
...  

2016 ◽  
Vol 477 (4) ◽  
pp. 1078-1084 ◽  
Author(s):  
Jun-Oh Kwon ◽  
Yong Deok Lee ◽  
Haemin Kim ◽  
Min Kyung Kim ◽  
Min-Kyoung Song ◽  
...  

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