Motor threshold, motor evoked potential, central motor conduction time

In this chapter, we survey parameters influencing the assessment of the size and latency of motor evoked potentials (MEP), in normal and pathological conditions, and methods to allow for a meaningful quantification of MEP characteristics. In line with the first edition of this textbook, we extensively discuss three established mechanisms of intrinsic physiological variance and collision techniques that aim to minimize their influence. For the first time, in line with the ever wider use of optical navigation and targeting systems in brain stimulation, we discuss novel methods to capture and minimize the influence of extrinsic biophysical variance. Together, following the rules laid out in this chapter, transcranial magnetic stimulation (TMS) can account for spinal and extrinsic biophysical variance to advance investigations of the central origins of MEP size and latency variability.

Predicting takeover response to silent automated vehicle failures

Current and foreseeable automated vehicles are not able to respond appropriately in all circumstances and require human monitoring. An experimental examination of steering automation failure shows that response latency, variability and corrective manoeuvring systematically depend on failure severity and the cognitive load of the driver. The results are formalised into a probabilistic predictive model of response latencies that accounts for failure severity, cognitive load and variability within and between drivers. The model predicts high rates of unsafe outcomes in plausible automation failure scenarios. These findings underline that understanding variability in failure responses is crucial for understanding outcomes in automation failures.

Can auditory warning signals normalize eye movements in children with ADHD?

Attenuated baseline arousal has been hypothesized to underlie symptoms of attention deficit/hyperactivity disorder (ADHD). A behavioral signature of reduced baseline arousal is an increased beneficiary effect of warning signals in reaction tasks. This paradoxical effect is believed to be caused by a temporary increase in arousal induced by warning signals. In a preregistered study, we tested the hypothesis that children with high levels of ADHD symptoms would be hyperresponsive to warning signals in a well-established visual attention task (the gap/overlap paradigm). Previous studies using this task have found slower and more variable saccadic reaction times in children with ADHD compared to typically developing children, suggesting that these eye movement metrics are candidate biomarkers. We examined 71 children, of which 1/3 had a diagnosis of ADHD, using both dimensional analyses and group comparisons. Previously reported findings of reduced saccadic latency and increased latency variability were replicated. Importantly, saccadic latency was normalized by auditory warning signals. Analyses of pupil dilation, a physiological index of arousal and locus coeruleus-noradrenergic activity, confirmed that warning signals led to enhanced arousal. Our findings are novel and contribute to our understanding of arousal and attention in ADHD and have implications for treatment and interventions.

Updating Misinformation in Memory after Correction: An Event-Related Potentials (ERP) Study

A key component in correcting misinformation is the removal of incorrect information and subsequent updating of the associated mental model. Whilst a body of behavioural research has examined this phenomenon, neuroscientific research in the area is lacking. The current study aimed to examine differences in three event-related potential (ERP) components associated with memory encoding and updating: a left-frontal positivity, the feedback-related negativity, and the parietal P3b. Participants were 39 young adults who were presented with 70 statements that they were required to judge as myths or facts whilst electroencephalographic data were recorded, and then again after a one-week retention interval. Differences between ERP component amplitudes of correctly and incorrectly classified statements were analysed when feedback was presented to participants during testing period 1. Behavioural performance improved across testing periods, but frequentist and Bayesian analyses found no differences between ERP amplitudes elicited by correct or incorrect feedback. It is likely that no effect was observed due to memory removal and updating processes being variable in terms of onset and/or duration. Future research could consider employing analyses that do not include a temporal dimension or adjust for latency variability to investigate if any reliable non-time-locked electrophysiological modulations occur during misinformation correction.

Measuring Sustained Attention and Perceived Workload

Objective: We examined the effects of spatial uncertainty, field dependence/independence (FD/I), and sex on vigilance performance and perceived workload in elementary school children. Background: Building on previous work in which children demonstrated their ability to evaluate workload, we tested whether spatial-uncertainty manipulations in a vigilance task would elicit in children the same deleterious effects on performance and workload as it does with adults. We also examined individual difference effects associated with FD/I and sex to determine their influence on both performance and workload. Method: In the low-uncertainty task, stimuli appeared in the center of the computer screen; in the high-uncertainty task, they appeared in one of the four quadrants of the screen. Neutral events consisted of uppercase letter strings. Critical signals consisted of a single lowercase letter among uppercase letters. Following each vigil, children completed a workload assessment via a modified version of the NASA Task Load Index. Results: Children showed lower perceptual sensitivity, greater response latency variability (RTSD), and a higher response criterion in the uncertain display condition. Workload scores reflected these performance differences. Field-dependent children showed lower perceptual sensitivity and greater RTSD than did field-independent children. The two groups exhibited differing workload profiles. Despite no objective performance differences, boys reported greater workload than girls. Conclusion: The scale demonstrated sensitivity and diagnosticity with regard to both the task variable and individual differences. Application: These findings contribute to the emerging field of “educational ergonomics” and indicate that appropriate assessment tools might identify children who are experiencing increased workload.

The Study of the Antisaccade Performance and Contingent Negative Variation Characteristics in First-Episode and Chronic Schizophrenia Patients

The study tested whether the antisaccade (AS) performance and Contingent Negative Variation (CNV) measures differed between the first-episode and chronic patients to provide the evidence of PFC progressive functional deterioration. Subjects included 15 first-episode and 20 chronic schizophrenic patients (with the duration of illness more than 5 years), and 21 control subjects. The first-episode and chronic patients had significantly elevated error percent (p < .05, effect size 1.10 and p < .001, effect size 1.25), increased AS latencies (p < .01, effect size 1.18 and p < .001, effect size 1.69), and increased latencies variability (p < .01, effect size 1.52 and p < .001, effect size 1.37) compared to controls. Chronic patients had marginally significant increase of the response latency (p = .086, effect size .78) and latency variability (p < .099, effect size .63) compared to first-episode ones. Results of CNV analysis revealed that chronic patients only exhibited robustly declined frontal CNV amplitude at Fz (p < .05, effect size .70), F3 (p < .05, effect size .88), and F4 (p < .05, effect size .71) sites compared to controls. The obtained results might be related to specific changes in prefrontal cortex function over the course of schizophrenia.