Shape-Tunable Polymeric Janus Nanoparticles with Hollow Cavities Derived from Polymerization Induced Self-Assembly Based Crosslinked Vesicles

Fabrications of shape-tunable polymeric Janus nanoparticles with hollow cavities derived from polymerization induced self-assembly based crosslinked vesicles are reported firstly in this work. These novel polymeric JNPs can be applied...

Multi-stimuli Responsive Bottlebrush-Colloid Janus Nanoparticles Toward Emulsion Interfacial Manipulation and Catalysis

A general approach is proposed to large scale synthesize multi-stimuli responsive bottlebrush-colloid Janus nanoparticles (JNPs) by preferentially tuning the composition of a single chain nanoparticle (SCNP). The starting SCNP is...

Cyclodextrin-Modified Nanomaterials for Drug Delivery: Classification and Advances in Controlled Release and Bioavailability

In drug delivery, one widely used way of overcoming the biopharmaceutical problems present in several active pharmaceutical ingredients, such as poor aqueous solubility, early instability, and low bioavailability, is the formation of inclusion compounds with cyclodextrins (CD). In recent years, the use of CD derivatives in combination with nanomaterials has shown to be a promising strategy for formulating new, optimized systems. The goals of this review are to give in-depth knowledge and critical appraisal of the main CD-modified or CD-based nanomaterials for drug delivery, such as lipid-based nanocarriers, natural and synthetic polymeric nanocarriers, nanosponges, graphene derivatives, mesoporous silica nanoparticles, plasmonic and magnetic nanoparticles, quantum dots and other miscellaneous systems such as nanovalves, metal-organic frameworks, Janus nanoparticles, and nanofibers. Special attention is given to nanosystems that achieve controlled drug release and increase their bioavailability during in vivo studies.

A Research of Stereo-Selective Synthesis of Silica-based Amphiphilic Janus Particles

Because Janus particles with specific asymmetric nanostructures can be fixed in the oil phase or water respectively, they are more suitable for Pickering emulsion stability. Furthermore, the complete separation of hydrophobic and hydrophobic regions makes adjusting the hydrophobic/hydrophobic region ratio possible by changing the volume ratio. In this study, the preparations of three asymmetric silicon-based amphiphilic Janus nanoparticles are introduced. The methods used are consecutive immobilization, seed emulsion polymerization, and selective encapsulation, respectively. Complete compartmentalization of hydrophilic and hydrophobic domains was realized by anchoring silica with nucleation site, seed emulsion polymerization, or surface charge repulsion. In addition, these nanoparticles can be easily functionalized, bringing new research opportunities to applications in catalysis, adsorption, separation and biomedicine.

Effect of temperature on the structure of Cu/Si composite Janus nanoparticles

This work determined the effect of temperature on the formation of composite Cu/Si nanoparticles by the molecular dynamics (MD) method. For the first time, the temperature dependence of the potential energy of hybrid nanoparticles, which were single-crystal spherical clusters cut from an ideal lattice, was studied. It is shown that phase transitions and structural ordering cause a sharp change in the potential energy of composite nanoparticles. The structural arrangement of copper nanoparticles at high temperatures was found.