The main argument elaborated in this chapter is that companies, particularly start-ups, need to continuously work on their business leadership, human capital, and organizational change and persistence in order to survive and keep thriving even in uncertain times, such as the post-COVID-19 period. Additionally, the chapter argues that Pfeffer's seven principles for organizational success are still very relevant today and recommends to start-ups to use this framework. The chapter draws from the literature on human capital and management, organizational structure and perseverance, and responsible business leadership. The drawings from the literature are then applied to a single case study, the recruitment consultancy The Big Search. The findings confirm that Pfeffer's seven principles for organizational success are highly relevant today to companies that do want to invest in their performance and success. Moreover, the findings show the challenges and opportunities that start-ups, such as The Big Search, have gone through.