The chapter argues that Pyrrho and ancient Pyrrhonian skepticism (specifically, Sextus Empiricus) are plausibly interpreted as accepting a self-cultivation philosophy, though in somewhat different senses and with some qualification. For both, the existential starting point is an emotionally troubled life rooted in beliefs about the world, and the ideal state of being is a life of tranquility without these beliefs and guided by appearances. It is difficult to say what spiritual exercises Pyrrho thought were needed to achieve the ideal state: perhaps learning his philosophy and habituating ourselves to follow it. However, for Sextus, employment of skeptical arguments was the primary exercise. Since neither Pyrrho nor Sextus supposed we could make assertions about the specific nature of things, neither had a philosophy of human nature in a straightforward sense. Nonetheless, presentations of their outlooks betray some perspective on this (e.g., about the relationship between absence of belief and tranquility).