The comparatively poor contemporary health profiles of Scotland and, in particular, Glasgow have become widely known. Drawing on a body of research compiled by the Glasgow Centre for Population Health, this chapter provides a detailed examination of the health profiles of these populations as they have been shaped over time. The chapter begins by tracing their historical development in their UK and European context, before turning to examine the political, social and economic causal factors and processes which have, over time, contributed to the particularly poor health outcomes experienced in Glasgow. Building on this knowledge, the chapter draws to a close by exploring the potential future health trajectory of the city’s population. Glasgow provides a potent case for other cities and countries as they consider the ways in which politics and policy come to shape health, and health inequalities, across their populations.