The Effects of Aspirin With Combined Compound Danshen Dropping Pills on Hemorheology and Blood Lipids in Middle-Aged and Elderly Patients With CHD: A Systematic Review and Meta-Analysis

Background: Coronary heart disease (CHD) is one of the most common diseases in clinical cardiovascular practice, mainly afflicting the middle-aged and elderly. It will greatly affect elderly quality of life, and even affect their psychological and physical health. At present, CHD is treated with western drugs alone, but this can produce drug dependency. In recent years, Traditional Chinese Medicine (TCM) combine western drugs has been used as a complementary and alternative therapy, and its effectiveness and safety have been proven, attracting the attention of numerous researchers.Objective: Our study aimed to compare the efficacy of Aspirin with Combined Compound Danshen Dropping Pills had a superior effect on the treatment of Hemorheology and Blood Lipids in Middle-aged and Elderly Patients with CHD. Determine the effectiveness and safety of Aspirin with Combined Compound Danshen Dropping Pills in the treatment of CHD, and obtain high quality clinical evidence.Methods: Based on the PRISMA Statement, inclusion and exclusion criteria were formulated. Randomized controlled trials (RCTs) on the Effects of Aspirin with Combined Compound Danshen Dropping Pills on Hemorheology and Blood Lipids in Middle-aged and Elderly Patients with CHD were found following a search of 4 mainstream medical databases. RCTs found to meet the study's requirement were included; data information was then extracted, and the quality assessed using the Cochrane bias risk assessment tool. Through RevMan software, Meta analysis was carried out for overall TC, TG, HDL-C, LDL-C hematocrit, high shear viscosity, low shear viscosity, plasma viscosity, PAGM, and TXB2 effective rate. The relative risk (RR) and 95% confidence interval (95% CI) were calculated; heterogeneity was tested and its source found; publication bias was assessed through the Egger and Begg tests, and by means of funnel plots.Result: 22 RCTs were found, involving 1,987 cases. The results of the Meta analysis showed that, compared to drug therapy alone, Aspirin with Combined Compound Danshen Dropping Pills had a superior effect on the treatment of Hemorheology and Blood Lipids in Middle-aged and Elderly Patients with CHD. The meta analysis results show the effects on TC [MD = −0.91, 95% CI (−1.09, −0.73)], on TG [MD = −0.94, 95% CI (−1.22, −0.66)], on HDL-C [MD = 0.40, 95% CI (0.27, 0.53)], on LDL-C [MD = −0.99, 95% CI (−1.24, −0.74)], on hematocrit [MD = −2.69, 95% CI (−3.73, −1.65)], on high shear blood viscosity [MD = −1.11, 95% CI (−2.18, −0.05)], on low shear viscosity [MD = −0.79, 95% CI (−0.89, −0.68)], on plasma viscosity [MD = −0.26, 95% CI (−0.52, 0.01)], on PAMG [MD = −10.75, 95% CI (−16.84, −4.67)], and on TXB2 [MD = −11.84, 95% CI (−14.75, −8.92)]. The source of heterogeneity might be related to the state of patient, efficacy of drugs in the control group and difference in judgment criteria for efficacy. The Egger test and Begg test showed that publication bias did not occur in our study.Conclusions: The combination of compound dropping pill DSP with aspirin has some therapeutic effect on blood lipids and hemorheology in patients with CHD, ince some of the RCTs featured a very small sample size, the reliability and validity of our study's conclusion may have been affected as well; therefore, the explanation should be treated with some caution. In the future, a large number of higher-quality RCTs are still needed to confirm the results of our study.

Impregnation of paper with cellulose nanofibrils and polyvinyl alcohol to enhance durability

Durable papers should exhibit high mechanical strength and good soiling resistance. In this study, cellulose nanofibrils (CNF) was investigated as an additive to the polyvinyl alcohol (PVA) impregnation solution to improve the durability of paper. The impregnation suspensions were prepared by adding CNF to PVA solution in various ratios, and were used to impregnate a base paper. The PVA-CNF suspensions exhibited good dispersion stability; however, the low shear viscosity increased as its CNF content increased. The pickup weights of the papers impregnated with the PVA-CNF suspensions were found to be lower than those of the control sample, which were impregnated with the pure PVA solution only. Although the strength of the paper was not significantly improved by the addition of CNF, when the paper was impregnated with a PVA-CNF suspension containing 5 % CNF content, the product exhibited similar strength to the papers impregnated with only a 3 % PVA solution despite its lower pickup weight. The mechanical strength of the impregnated paper was affected by the pickup weight and penetration of the impregnating agent. The addition of a wet strengthening agent to the mixed suspensions was seen to enhance the wet soiling resistance of the papers.

The Viscosity of Polyalphaolefins Mixtures at High Pressure and Stress

Understanding the pressure and shear dependence of viscosity is essential to an understanding of the mechanisms of film forming and friction in concentrated contacts. The blending of different molecular mass polyalphaolefins (PAOs) may permit the formulator to arrive at a desired combination of film thickness and friction. The viscosities of PAO base oils and their blends were measured versus temperature, pressure, and shear stress to 1 GPa in pressure. The Grunberg–Nissan mixing rule, with effective mole fractions, provides an excellent mixing rule for the temperature and pressure-dependent low-shear viscosity. This work provides the first look at a possible mixing rule for the non-Newtonian response of mixtures of base oils.